Search Results - "JOSEPH, Leroy"

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…Obesity and high saturated fat intake increase the risk of heart failure and arrhythmias. The molecular mechanisms are poorly understood. We hypothesized that…”
Get full text

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene by Chatzifrangkeskou, Maria, Le Dour, Caroline, Wu, Wei, Morrow, John P, Joseph, Leroy C, Beuvin, Maud, Sera, Fusako, Homma, Shunichi, Vignier, Nicolas, Mougenot, Nathalie, Bonne, Gisèle, Lipson, Kenneth E, Worman, Howard J, Muchir, Antoine

“…Cardiomyopathy caused by lamin A/C gene mutations (LMNA cardiomyopathy) is characterized by increased myocardial fibrosis, which impairs left ventricular…”
Get full text

Paracardial fat and vitamin A: a mechanism for regulating exercise performance by Joseph, Leroy C, Morrow, John P

“…Different fat depots have different physiologic functions. In a provocative study published in this issue of the JCI, Petrosino et al. investigate the role of…”
Get full text

ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy by Antoku, Susumu, Wu, Wei, Joseph, Leroy C., Morrow, John P., Worman, Howard J., Gundersen, Gregg G.

“…Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate…”
Get full text

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia by Joseph, Leroy C., PhD, Subramanyam, Prakash, PhD, Radlicz, Christopher, BS, Trent, Chad M., PhD, Iyer, Vivek, MD, MSE, Colecraft, Henry M., PhD, Morrow, John P., MD, FHRS

“…Background Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in…”
Get full text

PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction by Joseph, Leroy C, Reyes, Michael V, Lakkadi, Kundanika R, Gowen, Blake H, Hasko, Gyorgy, Drosatos, Konstantinos, Morrow, John P

“…Sepsis-induced cardiomyopathy (SIC) is associated with increased patient mortality. At present, there are no specific therapies for SIC. Previous studies have…”
Get more information

Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway by Mei, Lin, Zheng, Yun-Min, Song, Tengyao, Yadav, Vishal R., Joseph, Leroy C., Truong, Lillian, Kandhi, Sharath, Barroso, Margarida M., Takeshima, Hiroshi, Judson, Marc A., Wang, Yong-Xiao

“…Ca 2+ signaling in pulmonary arterial smooth muscle cells (PASMCs) plays an important role in pulmonary hypertension (PH). However, the underlying specific ion…”
Get full text

Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2) by Joseph, Leroy C, Avula, Uma Mahesh R, Wan, Elaine Y, Reyes, Michael V, Lakkadi, Kundanika R, Subramanyam, Prakash, Nakanishi, Koki, Homma, Shunichi, Muchir, Antoine, Pajvani, Utpal B, Thorp, Edward B, Reiken, Steven R, Marks, Andrew R, Colecraft, Henry M, Morrow, John P

“…BACKGROUND:Obesity and diets high in saturated fat increase the risk of arrhythmias and sudden cardiac death. However, the molecular mechanisms are not well…”
Get full text

The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet by Joseph, Leroy C., Reyes, Michael V., Homan, Edwin A., Gowen, Blake, Avula, Uma Mahesh R., Goulbourne, Chris N., Wan, Elaine Y., Elrod, John W., Morrow, John P.

“…Obesity and diabetes increase the risk of arrhythmia and sudden cardiac death. However, the molecular mechanisms of arrhythmia caused by metabolic…”
Get full text

Fire promotes pollinator visitation: implications for ameliorating declines of pollination services by Van Nuland, Michael E, Haag, Elliot N, Bryant, Jessica A M, Read, Quentin D, Klein, Robert N, Douglas, Morgan J, Gorman, Courtney E, Greenwell, Trey D, Busby, Mark W, Collins, Jonathan, Leroy, Joseph T, Schuchmann, George, Schweitzer, Jennifer A, Bailey, Joseph K

“…Pollinators serve critical roles for the functioning of terrestrial ecosystems, and have an estimated annual value of over $150 billion for global agriculture…”
Get full text

Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function by Joseph, Leroy C, Kokkinaki, Dimitra, Valenti, Mesele-Christina, Kim, Grace J, Barca, Emanuele, Tomar, Dhanendra, Hoffman, Nicholas E, Subramanyam, Prakash, Colecraft, Henry M, Hirano, Michio, Ratner, Adam J, Madesh, Muniswamy, Drosatos, Konstantinos, Morrow, John P

“…Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have…”
Get full text

Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…[This corrects the article DOI: 10.1371/journal.pone.0145750.]…”
Get full text

Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription by Huang, Haiyan, Joseph, Leroy C, Gurin, Michael I, Thorp, Edward B, Morrow, John P

“…Abstract Pathologic cardiac hypertrophy can lead to heart failure, but the mechanisms involved are poorly understood. SERCA2 is critical for normal cardiac…”
Get full text

Postnatal development of mice with combined genetic depletions of lamin A/C, emerin and lamina-associated polypeptide 1 by Wang, Yuexia, Shin, Ji-Yeon, Nakanishi, Koki, Homma, Shunichi, Kim, Grace J, Tanji, Kurenai, Joseph, Leroy C, Morrow, John P, Stewart, Colin L, Dauer, Willian T, Worman, Howard J

“…Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a…”
Get full text

Combined metabolomic and transcriptomic profiling approaches reveal the cardiac response to high-fat diet by Joseph, Leroy C., Shi, Jianting, Nguyen, Quynh N., Pensiero, Victoria, Goulbourne, Chris, Bauer, Robert C., Zhang, Hanrui, Morrow, John P.

“…The response of vital organs to different types of nutrition or diet is a fundamental question in physiology. We examined the cardiac response to 4 weeks of…”
Get full text

Mechanisms of Chronic Metabolic Stress in Arrhythmias by Gowen, Blake H., Reyes, Michael V., Joseph, Leroy C., Morrow, John P.

“…Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing…”
Get full text

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice by Shin, Ji-Yeon, Le Dour, Caroline, Sera, Fusako, Iwata, Shinichi, Homma, Shunichi, Joseph, Leroy C, Morrow, John P, Dauer, William T, Worman, Howard J

“…We previously showed that striated muscle-selective depletion of lamina-associated polypeptide 1 (LAP1), an integral inner nuclear membrane protein, leads to…”
Get full text

Antiestrogenic and anticancer activities of peptides derived from the active site of alpha-fetoprotein by Joseph, Leroy C., Bennett, James A., Kirschner, Karl N., Shields, George C., Hughes, John, Lostritto, Nicole, Jacobson, Herbert I., Andersen, Thomas T.

“…Cyclo[EKTOVNOGN] (AFPep), a cyclic 9‐amino acid peptide derived from the active site of alpha‐fetoprotein, has been shown to prevent carcinogen‐induced mammary…”
Get full text

Paracardial fat and vitamin A: a mechanism for regulating exercise performance by Joseph, Leroy C, Morrow, John P

“…Different fat depots have different physiologic functions. In a provocative study published in this issue of the JCI, Petrosino et al. investigate the role of…”
Get full text

Abstract P3055: Combined Metabolomic And Transcriptomic Profiling Approaches Reveal The Cardiac Response To High-fat Diet by Morrow, John P, Joseph, Leroy C, Nguyen, Quynh, Shi, Jianting, Zhang, Hanrui

“…The response of vital organs to different types of nutrition or diet is a fundamental question in physiology. It is unclear how different diets can alter…”
Get full text