Search Results - "JORDAN, Mary Ann"

Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy by LaPointe, Nichole E., Morfini, Gerardo, Brady, Scott T., Feinstein, Stuart C., Wilson, Leslie, Jordan, Mary Ann

“…•We compare the effects of four microtubule-targeting drugs on fast axonal transport.•All four drugs inhibit anterograde transport in axoplasm, with varying…”
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Erucin, the major isothiocyanate in arugula (Eruca sativa), inhibits proliferation of MCF7 tumor cells by suppressing microtubule dynamics by Azarenko, Olga, Jordan, Mary Ann, Wilson, Leslie

“…Consumption of cruciferous vegetables is associated with reduced risk of various types of cancer. Isothiocyanates including sulforaphane and erucin are…”
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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic Instability by Smith, Jennifer A, Wilson, Leslie, Azarenko, Olga, Zhu, Xiaojie, Lewis, Bryan M, Littlefield, Bruce A, Jordan, Mary Ann

“…Eribulin mesylate (E7389), a synthetic analogue of the marine natural product halichondrin B, is in phase III clinical trials for the treatment of cancer…”
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Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase by Okouneva, Tatiana, Azarenko, Olga, Wilson, Leslie, Littlefield, Bruce A, Jordan, Mary Ann

“…Eribulin (E7389), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. At low…”
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Modulation of Microtubule Dynamics by Drugs : A Paradigm for the Actions of Cellular Regulators by Wilson, Leslie, Panda, Dulal, Jordan, Mary Ann

“…Microtubules are intrinsically dynamic polymers. Two kinds of dynamic behaviors, dynamic instability and treadmilling, are important for microtubule function…”
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Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : implications for the role of microtubule dynamics in mitosis by JORDAN, M. A, THROWER, D, WILSON, L

“…Inhibition of mitosis by many drugs that bind to tubulin has been attributed to depolymerization of microtubules. However, we found previously that low…”
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Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability by Oroudjev, Emin, Lopus, Manu, Wilson, Leslie, Audette, Charlene, Provenzano, Carmela, Erickson, Hans, Kovtun, Yelena, Chari, Ravi, Jordan, Mary Ann

“…Maytansine and its analogues (maytansinoids) are potent microtubule-targeted compounds that inhibit proliferation of cells at mitosis. Antibody-maytansinoid…”
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Ixabepilone: targeting βIII-tubulin expression in taxane-resistant malignancies by Dumontet, Charles, Jordan, Mary Ann, Lee, Francis F.Y.

“…Microtubule-targeting agents, such as taxanes and epothilones, block mitosis and cell proliferation by targeting the dynamics of the cytoskeleton. The taxanes…”
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The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth by Jordan, Mary Ann, Kamath, Kathryn, Manna, Tapas, Okouneva, Tatiana, Miller, Herbert P, Davis, Celia, Littlefield, Bruce A, Wilson, Leslie

“…E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of the marine sponge natural product halichondrin B. Whereas its…”
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Structural Basis for Induction of Peripheral Neuropathy by Microtubule-Targeting Cancer Drugs by Smith, Jennifer A, Slusher, Barbara S, Wozniak, Krystyna M, Farah, Mohamed H, Smiyun, Gregoriy, Wilson, Leslie, Feinstein, Stuart, Jordan, Mary Ann

“…Peripheral neuropathy is a serious, dose-limiting side effect of cancer treatment with microtubule-targeting drugs. Symptoms present in a "stocking-glove"…”
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Hesperidin suppressed proliferations of both Human breast cancer and androgen-dependent prostate cancer cells by Lee, Choong Jae, Wilson, Leslie, Jordan, Mary Ann, Nguyen, Vy, Tang, Jessica, Smiyun, Gregory

“…Hesperidin, a flavonoid derived from citrus fruits, has been reported to show various biological effects including anticancer activity. This study investigated…”
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Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics by Yenjerla, Mythili, Cox, Corey, Wilson, Leslie, Jordan, Mary Ann

“…Carbendazim (methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food production and appears to act on fungal tubulin. However, it…”
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Mechanisms of inhibition of endothelial cell migration by taxanes by Kamath, Kathy, Smiyun, Greg, Wilson, Leslie, Jordan, Mary Ann

“…Several antiangiogenic mechanisms have been proposed for the widely‐used cancer chemotherapeutic drugs taxotere (docetaxel) and taxol (paclitaxel), but none…”
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Microtubules and actin filaments: dynamic targets for cancer chemotherapy by Jordan, Mary Ann, Wilson, Leslie

“…Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing…”
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2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules by Kamath, Kathy, Okouneva, Tatiana, Larson, Gary, Panda, Dulal, Wilson, Leslie, Jordan, Mary Ann

“…2-Methoxyestradiol (2ME2), a metabolite of estradiol-17β, is a novel antimitotic and antiangiogenic drug candidate in phase I and II clinical trials for the…”
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Taxol suppresses dynamics of individual microtubules in living human tumor cells by Yvon, A M, Wadsworth, P, Jordan, M A

“…Microtubules are intrinsically dynamic polymers, and their dynamics play a crucial role in mitotic spindle assembly, the mitotic checkpoint, and chromosome…”
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Erratum: Microtubule-binding agents: a dynamic field of cancer therapeutics by Dumontet, Charles, Jordan, Mary Ann

“…Nature Reviews Drug Discovery 9, 790–803 (2010) In figure 1, there were errors in the chemical structures of vinflunine, cevipabulin and eribulin. The correct…”
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Microtubule-binding agents: a dynamic field of cancer therapeutics by Dumontet, Charles, Jordan, Mary Ann

“…Key Points Microtubule-binding agents are one of the oldest and most diverse family of anticancer agents. This family has recently been enriched with the…”
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Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration by Bunker, Janis M, Wilson, Leslie, Jordan, Mary Ann, Feinstein, Stuart C

“…The neural microtubule-associated protein tau binds to and stabilizes microtubules. Because of alternative mRNA splicing, tau is expressed with either 3 or 4…”
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FTDP-17 Mutations Compromise the Ability of Tau to Regulate Microtubule Dynamics in Cells by Bunker, Janis M., Kamath, Kathy, Wilson, Leslie, Jordan, Mary Ann, Feinstein, Stuart C.

“…The neural microtubule-associated protein Tau binds directly to microtubules and regulates their dynamic behavior. In addition to being required for normal…”
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