Search Results - "JORCANO, J. L"

Skin-on-a-chip models: General overview and future perspectives by Risueño, I., Valencia, L., Jorcano, J. L., Velasco, D.

“…Over the last few years, several advances have been made toward the development and production of in vitro human skin models for the analysis and testing of…”
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A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept by Valencia, L., Canalejas-Tejero, V., Clemente, M., Fernaud, I., Holgado, M., Jorcano, J. L., Velasco, D.

“…Microfluidic-based tissues-on-chips (TOCs) have thus far been restricted to modelling simple epithelia as a single cell layer, but likely due to technical…”
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An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells by Alameda, J P, Moreno-Maldonado, R, Navarro, M, Bravo, A, Ramírez, A, Page, A, Jorcano, J L, Fernández-Aceñero, M J, Casanova, M L

“…In this study, we demonstrate that the expression in tumorigenic epidermal cells of a catalytically inactive form of CYLD (CYLD C/S ) that mimics the…”
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Conditional ablation of C/EBPβ demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis by STERNECK, E, ZHU, S, RAMIREZ, A, JORCANO, J. L, SMART, R. C

“…The CCAAT/enhancer binding protein beta (C/EBP beta) is implicated in the regulation of many different molecular and physiological processes. Mice with a…”
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The first COL7A1 mutation survey in a large Spanish dystrophic epidermolysis bullosa cohort: c.6527insC disclosed as an unusually recurrent mutation by Escámez, M.J., García, M., Cuadrado-Corrales, N., Llames, S.G., Charlesworth, A., De Luca, N., Illera, N., Sánchez-Jimeno, C., Holguín, A., Duarte, B., Trujillo-Tiebas, M.J., Vicario, J.L., Santiago, J.L., Hernández-Martín, A., Torrelo, A., Castiglia, D., Ayuso, C., Larcher, F., Jorcano, J.L., Meana, A., Meneguzzi, G., Zambruno, G., Del Rio, M.

“…Summary Background  Dystrophic epidermolysis bullosa (DEB) is a genodermatosis caused by mutations in COL7A1. The clinical manifestations are highly variable…”
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Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK by ESSAYEM, S, KOVACIC-MILIVOJEVIC, B, FISHER, S. J, JORCANO, J. L, BEGGS, H. E, REICHARDT, L. F, ILIC, D, BAUMBUSCH, C, MCDONAGH, S, DOLGANOV, G, HOWERTON, K, LAROCQUE, N, MAURO, T, RAMIREZ, A, RAMOS, D. M

“…Focal adhesion kinase (FAK) is a critical component in transducing signals downstream of both integrins and growth factor receptors. To determine how the loss…”
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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure by Murillas, R., Larcher, F., Conti, C. J., Santos, M., Ullrich, A., Jorcano, J. L.

“…Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well…”
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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation by Kaya, G, Rodriguez, I, Jorcano, J L, Vassalli, P, Stamenkovic, I

“…CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate. Although CD44-mediated cell…”
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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development by LARCHER, F, MURILLAS, R, BOLONTRADE, M, CONTI, C. J, JORCANO, J. L

“…Upregulation of keratinocyte-derived VEGF-A expression has recently been established in non-neoplastic processes of skin such as wound healing, blistering…”
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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein by PARAMIO, J. M, NAVARRO, M, SEGRELLES, C, GOMEZ-CASERO, E, JORCANO, J. L

“…The tumour suppressor PTEN, also named MMAC1 or TEP1, is associated with a number of malignancies in human populations. This protein has a dual protein…”
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Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis by BUDUNOVA, I. V, PEREZ, P, VADEN, V. R, SPIEGELMAN, V. S, SLAGA, T. J, JORCANO, J. L

“…To elucidate the possible role of NF-κB in mouse skin carcinogenesis we studied the expression of p50 (NF-κB1), p52 (NF-κB2), p65 (RelA) and IκB-α inhibitor as…”
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Publisher's Note: “Skin-on-a-chip models: General overview and future perspectives” [APL Bioengineering 5, 030901 (2021)] by Risueño, I., Valencia, L., Jorcano, J. L., Velasco, D.

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Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor by Pérez, Paloma, Page, Angustias, Bravo, Ana, Río, Marcela, Giménez‐Conti, Irma, Budunova, Irina, Slaga, Thomas J., Jorcano, José L.

“…Glucocorticoids (GCs) are potent inhibitors of epidermal proliferation and effective anti‐inflammatory compounds, which make them the drug of choice for a wide…”
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Current approaches and perspectives in human keratinocyte-based gene therapies by Del Rio, M, Gache, Y, Jorcano, J L, Meneguzzi, G, Larcher, F

“…Inherited and acquired disorders are liable to treatment with somatic gene therapy. The skin, and in particular epidermal cells, are particularly suited to…”
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Nonviral transfer of genes to pig primary keratinocytes. Induction of angiogenesis by composite grafts of modified keratinocytes overexpressing VEGF driven by a keratin promoter by DEL RIO, M, LARCHER, F, MEANA, A, SEGOVIA, J. C, ALVAREZ, A, JORCANO, J. L

“…Cultured epithelial grafts have proven to be life-saving in the treatment of large skin losses. It has become apparent that one of the main difficulties of…”
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Expression of Cyclin D1 in Epithelial Tissues of Transgenic Mice Results in Epidermal Hyperproliferation and Severe Thymic Hyperplasia by Robles, Ana I., Larcher, Fernando, Whalin, Robert B., Murillas, Rodolfo, Richie, Ellen, Gimenez-Conti, Irma B., Jorcano, Jose L., Conti, Claudio J.

“…To study the involvement of cyclin D1 in epithelial growth and differentiation and its putative role as an oncogene in skin, transgenic mice were developed…”
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Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation by Paramio, Jesús M., Segrelles, Carmen, Casanova, M. Llanos, Jorcano, José L.

“…Proteins of the retinoblastoma family (pRb, p107, and p130) modulate cell proliferation, a function related to their capacity to control the activity of the…”
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Up-regulation of Vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels by LARCHER, F, ROBLES, A. I, DURAN, H, MURILLAS, R, QUINTANILLA, M, CANO, A, CONTI, C. J, JORCANO, J. L

“…Angiogenesis is a crucial process for tumor growth and metastasis regulated by the balance of positive and negative factors. Vascular endothelial growth factor…”
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Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation by PARAMIO, J. M, LAIN, S, SEGRELLES, C, LANE, E. B, JORCANO, J. L

“…Terminal differentiation requires cell cycle withdrawal, suggesting the involvement of negative cell cycle controllers in the process. We have analysed the…”
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Role of protein kinases in the in vitro differentiation of human epidermal HaCaT cells by PARAMIO, J. M, JORCANO, J. L

“…Different chemicals that specifically and selectively inhibit or activate protein kinases have been used to define the possible roles of these enzymes in the…”
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