Search Results - "JORCANO, J"

Skin-on-a-chip models: General overview and future perspectives by Risueño, I., Valencia, L., Jorcano, J. L., Velasco, D.

“…Over the last few years, several advances have been made toward the development and production of in vitro human skin models for the analysis and testing of…”
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A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept by Valencia, L., Canalejas-Tejero, V., Clemente, M., Fernaud, I., Holgado, M., Jorcano, J. L., Velasco, D.

“…Microfluidic-based tissues-on-chips (TOCs) have thus far been restricted to modelling simple epithelia as a single cell layer, but likely due to technical…”
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An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells by Alameda, J P, Moreno-Maldonado, R, Navarro, M, Bravo, A, Ramírez, A, Page, A, Jorcano, J L, Fernández-Aceñero, M J, Casanova, M L

“…In this study, we demonstrate that the expression in tumorigenic epidermal cells of a catalytically inactive form of CYLD (CYLD C/S ) that mimics the…”
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Conditional ablation of C/EBPβ demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis by STERNECK, E, ZHU, S, RAMIREZ, A, JORCANO, J. L, SMART, R. C

“…The CCAAT/enhancer binding protein beta (C/EBP beta) is implicated in the regulation of many different molecular and physiological processes. Mice with a…”
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The first COL7A1 mutation survey in a large Spanish dystrophic epidermolysis bullosa cohort: c.6527insC disclosed as an unusually recurrent mutation by Escámez, M.J., García, M., Cuadrado-Corrales, N., Llames, S.G., Charlesworth, A., De Luca, N., Illera, N., Sánchez-Jimeno, C., Holguín, A., Duarte, B., Trujillo-Tiebas, M.J., Vicario, J.L., Santiago, J.L., Hernández-Martín, A., Torrelo, A., Castiglia, D., Ayuso, C., Larcher, F., Jorcano, J.L., Meana, A., Meneguzzi, G., Zambruno, G., Del Rio, M.

“…Summary Background  Dystrophic epidermolysis bullosa (DEB) is a genodermatosis caused by mutations in COL7A1. The clinical manifestations are highly variable…”
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Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK by ESSAYEM, S, KOVACIC-MILIVOJEVIC, B, FISHER, S. J, JORCANO, J. L, BEGGS, H. E, REICHARDT, L. F, ILIC, D, BAUMBUSCH, C, MCDONAGH, S, DOLGANOV, G, HOWERTON, K, LAROCQUE, N, MAURO, T, RAMIREZ, A, RAMOS, D. M

“…Focal adhesion kinase (FAK) is a critical component in transducing signals downstream of both integrins and growth factor receptors. To determine how the loss…”
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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development by LARCHER, F, MURILLAS, R, BOLONTRADE, M, CONTI, C. J, JORCANO, J. L

“…Upregulation of keratinocyte-derived VEGF-A expression has recently been established in non-neoplastic processes of skin such as wound healing, blistering…”
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Publisher's Note: “Skin-on-a-chip models: General overview and future perspectives” [APL Bioengineering 5, 030901 (2021)] by Risueño, I., Valencia, L., Jorcano, J. L., Velasco, D.

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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation by Kaya, G, Rodriguez, I, Jorcano, J L, Vassalli, P, Stamenkovic, I

“…CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate. Although CD44-mediated cell…”
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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure by Murillas, R., Larcher, F., Conti, C. J., Santos, M., Ullrich, A., Jorcano, J. L.

“…Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well…”
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Inhibition of Protein Kinase B (PKB) and PKCζ Mediates Keratin K10-Induced Cell Cycle Arrest by Paramio, Jesus M., Segrelles, Carmen, Ruiz, Sergio, Jorcano, José L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein by PARAMIO, J. M, NAVARRO, M, SEGRELLES, C, GOMEZ-CASERO, E, JORCANO, J. L

“…The tumour suppressor PTEN, also named MMAC1 or TEP1, is associated with a number of malignancies in human populations. This protein has a dual protein…”
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Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes by Brakebusch, C, Grose, R, Quondamatteo, F, Ramirez, A, Jorcano, J L, Pirro, A, Svensson, M, Herken, R, Sasaki, T, Timpl, R, Werner, S, Fässler, R

“…beta 1 integrins are ubiquitously expressed receptors that mediate cell-cell and cell-extracellular matrix interactions. To analyze the function of beta1…”
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Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis by BUDUNOVA, I. V, PEREZ, P, VADEN, V. R, SPIEGELMAN, V. S, SLAGA, T. J, JORCANO, J. L

“…To elucidate the possible role of NF-κB in mouse skin carcinogenesis we studied the expression of p50 (NF-κB1), p52 (NF-κB2), p65 (RelA) and IκB-α inhibitor as…”
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Analysis of the Ultraviolet B Response in Primary Human Keratinocytes Using Oligonucleotide Microarrays by Sesto, Angela, Navarro, Manuel, Burslem, Frank, Jorcano, José L.

“…UV radiation is the most important environmental skin aggressor, causing cancer and other problems. This paper reports the use of oligonucleotide microarray…”
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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes by González-Suárez, Eva, Samper, Enrique, Ramírez, Angel, Flores, Juana M., Martín-Caballero, Juan, Jorcano, José L., Blasco, María A.

“…Telomerase transgenics are an important tool to assess the role of telomerase in cancer, as well as to evaluate the potential use of telomerase for gene…”
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Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor by Pérez, Paloma, Page, Angustias, Bravo, Ana, Río, Marcela, Giménez‐Conti, Irma, Budunova, Irina, Slaga, Thomas J., Jorcano, José L.

“…Glucocorticoids (GCs) are potent inhibitors of epidermal proliferation and effective anti‐inflammatory compounds, which make them the drug of choice for a wide…”
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Human plasma as a dermal scaffold for the generation of a completely autologous bioengineered skin by LLAMES, Sara G, DEL RIO, Marcela, LARCHER, Fernando, GARCIA, Eva, GARCIA, Marta, ESCAMEZ, Maria José, JORCANO, Jose L, HOLGUIN, Purificacion, MEANA, Alvaro

“…Keratinocyte cultures have been used for the treatment of severe burn patients. Here, we describe a new cultured bioengineered skin based on (1) keratinocytes…”
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Current approaches and perspectives in human keratinocyte-based gene therapies by Del Rio, M, Gache, Y, Jorcano, J L, Meneguzzi, G, Larcher, F

“…Inherited and acquired disorders are liable to treatment with somatic gene therapy. The skin, and in particular epidermal cells, are particularly suited to…”
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Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis by Ruiz, Sergio, Santos, Mirentxu, Segrelles, Carmen, Leis, Hugo, Jorcano, José Luis, Berns, Anton, Paramio, Jesús M, Vooijs, Marc

“…The retinoblastoma gene product, pRb, plays a crucial role in cell cycle regulation, differentiation and inhibition of oncogenic transformation. pRb and its…”
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