Search Results - "JOOS, Stefan"

The role of Bcl-2 family members in tumorigenesis by Kirkin, Vladimir, Joos, Stefan, Zörnig, Martin

“…The Bcl-2 family consists of about 20 homologues of important pro- and anti-apoptotic regulators of programmed cell death. The established mode of function of…”
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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas by Pfister, Stefan, Janzarik, Wibke G, Remke, Marc, Ernst, Aurélie, Werft, Wiebke, Becker, Natalia, Toedt, Grischa, Wittmann, Andrea, Kratz, Christian, Olbrich, Heike, Ahmadi, Rezvan, Thieme, Barbara, Joos, Stefan, Radlwimmer, Bernhard, Kulozik, Andreas, Pietsch, Torsten, Herold-Mende, Christel, Gnekow, Astrid, Reifenberger, Guido, Korshunov, Andrey, Scheurlen, Wolfram, Omran, Heymut, Lichter, Peter

“…The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors,…”
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Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci by PFISTER, Stefan, REMKE, Marc, KULOZIK, Andreas, REIFENBERGER, Guido, RUTKOWSKI, Stefan, WIESTLER, Otmar D, RADLWIMMER, Bernhard, SCHEURLEN, Wolfram, LICHTER, Peter, KORSHUNOV, Andrey, BENNER, Axel, MENDRZYK, Frank, TOEDT, Grischa, FELSBERG, Jörg, WITTMANN, Andrea, DEVENS, Frauke, GERBER, Nicolas U, JOOS, Stefan

“…Medulloblastoma is the most common malignant brain tumor in children. Current treatment decisions are based on clinical variables. Novel tumor-derived…”
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German Cancer Consortium (DKTK) – A national consortium for translational cancer research by Joos, Stefan, Nettelbeck, Dirk M., Reil‐Held, Anette, Engelmann, Katja, Moosmann, Alexandra, Eggert, Angelika, Hiddemann, Wolfgang, Krause, Mechthild, Peters, Christoph, Schuler, Martin, Schulze‐Osthoff, Klaus, Serve, Hubert, Wick, Wolfgang, Puchta, Josef, Baumann, Michael

“…The German Cancer Consortium (‘Deutsches Konsortium für Translationale Krebsforschung’, DKTK) is a long‐term cancer consortium, bringing together the German…”
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Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma by Freier, Kolja, Knoepfle, Karl, Flechtenmacher, Christa, Pungs, Susanne, Devens, Frauke, Toedt, Grischa, Hofele, Christof, Joos, Stefan, Lichter, Peter, Radlwimmer, Bernhard

“…Gene copy number aberrations are involved in oral squamous cell carcinoma (OSCC) development. To delineate candidate genes inside critical chromosomal regions,…”
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Genomic and Protein Expression Profiling Identifies CDK6 As Novel Independent Prognostic Marker in Medulloblastoma by MENDRZYK, Frank, RADLWIMMER, Bernhard, KORSHUNOV, Andrey, LICHTER, Peter, JOOS, Stefan, KOKOCINSKI, Felix, BENNER, Axel, STANGE, Daniel E, NEBEN, Kai, FIEGLER, Heike, CARTER, Nigel P, REIFENBERGER, Guido

“…Medulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly half of the patients die as a result of…”
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Epigenetic Downregulation of Mitogen-Activated Protein Kinase Phosphatase MKP-2 Relieves Its Growth Suppressive Activity in Glioma Cells by WAHA, Anke, FELSBERG, Jörg, WIESTLER, Otmar D, REIFENBERGER, Guido, PIETSCH, Torsten, WAHA, Andreas, HARTMANN, Wolfgang, VON DEM KNESEBECK, Anna, MIKESKA, Thomas, JOOS, Stefan, WOLTER, Marietta, KOCH, Arend, YAN, Pearlly S, ENDL, Elmar

“…Critical tumor suppression pathways in brain tumors have yet to be fully defined. Along with mutational analyses, genome-wide epigenetic investigations may…”
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Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma by Mathas, Stephan, Kreher, Stephan, Meaburn, Karen J, Jöhrens, Korinna, Lamprecht, Björn, Assaf, Chalid, Sterry, Wolfram, Kadin, Marshall E, Daibata, Masanori, Joos, Stefan, Hummel, Michael, Stein, Harald, Janz, Martin, Anagnostopoulos, Ioannis, Schrock, Evelin, Misteli, Tom, Dörken, Bernd

“…Although the identification and characterization of translocations have rapidly increased, little is known about the mechanisms of how translocations occur in…”
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Activation of MAP Kinase Signaling Through ERK5 But Not ERK1 Expression Is Associated with Lymph Node Metastases in Oral Squamous Cell Carcinoma (OSCC) by Sticht, Carsten, Freier, Kolja, Knöpfle, Karl, Flechtenmacher, Christa, Pungs, Susanne, Hofele, Christof, Hahn, Meinhard, Joos, Stefan, Lichter, Peter

“…In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling was performed using a…”
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HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma by Brezniceanu, Marie-Luise, Völp, Kirsten, Bösser, Susanne, Solbach, Christine, Lichter, Peter, Joos, Stefan, Zörnig, Martin

“…ABSTRACT Apoptosis is a fundamental biological process used to eliminate unwanted cells in a multicellular organism. An increasing number of regulatory…”
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Genomic profiling reveals subsets of dedifferentiated liposarcoma to follow separate molecular pathways by Rieker, Ralf J., Weitz, Juergen, Lehner, Burkhard, Egerer, Gerlinde, Mueller, Andrea, Kasper, Bernd, Schirmacher, Peter, Joos, Stefan, Mechtersheimer, Gunhild

“…With the aim to provide more insight into their biology, a series of 79 liposarcomas (LS) representative of all main subtypes was analysed for chromosomal…”
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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2 by Joos, Stefan, Menz, Christiane K., Wrobel, Gunnar, Siebert, Reiner, Gesk, Stefan, Ohl, Sibylle, Mechtersheimer, Gunhild, Trümper, Lorenz, Möller, Peter, Lichter, Peter, Barth, Thomas F.E.

“…Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients comprising 8 lymphocyte-rich (cHL-LR), 16…”
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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2 by Joos, Stefan, Granzow, Martin, Holtgreve‐Grez, Heidi, Siebert, Reiner, Harder, Lana, Martín‐Subero, José I., Wolf, Jürgen, Adamowicz, Martyna, Barth, Thomas F.E., Lichter, Peter, Jauch, Anna

“…Four Hodgkin's lymphoma cell lines (KM‐H2, HDLM‐2, L428, L1236) were analyzed for cytogenetic aberrations, applying multiplex fluorescence in situ…”
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Mediastinal (thymic) large B-cell lymphoma: where do we stand? by Barth, Thomas F E, Leithäuser, Frank, Joos, Stefan, Bentz, Martin, Möller, Peter

“…Mediastinal (thymic) B-cell lymphoma (MBL) is a locally highly aggressive tumour that was first definitively described in the early 1980s. The incidence of MBL…”
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Methane activation by platinum cluster ions in the gas phase: effects of cluster charge on the Pt4 tetramer by Achatz, Uwe, Berg, Christian, Joos, Stefan, Fox, Brigitte S, Beyer, Martin K, Niedner-Schatteburg, Gereon, Bondybey, Vladimir E

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COX‐2 upregulation in thymomas and thymic carcinomas by Rieker, Ralf J., Joos, Stefan, Mechtersheimer, Gunhild, Blaeker, Hendrik, Schnabel, Philipp A., Morresi‐Hauf, Alicia, Hecker, Erich, Thomas, Michael, Dienemann, Hendrik, Schirmacher, Peter, Kern, Michael A.

“…The treatment of advanced stage thymomas and thymic carcinomas is a multimodal therapy. New therapeutic targets are currently under investigation, including…”
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Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD by Grund, Kerstin, Ahmadi, Rezvan, Jung, Fortunata, Funke, Verena, Gdynia, Georg, Benner, Axel, Sykora, Jaromir, Walczak, Henning, Joos, Stefan, Felsberg, Jörg, Reifenberger, Guido, Wiestler, Otmar D., Herold-Mende, Christel, Roth, Wilfried

“…Resistance to apoptosis is one reason for the poor response of malignant brain tumors to therapy. The PPARγ-modulating drug Troglitazone down-regulates the…”
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Frequent high telomerase reverse transcriptase expression in primary oral squamous cell carcinoma by Freier, Kolja, Pungs, Susanne, Flechtenmacher, Christa, Bosch, Franz X., Lichter, Peter, Joos, Stefan, Hofele, Christof

“…Background:  Gene copy number gain of chromosomal arm 5p is frequently found in oral squamous cell carcinoma (OSCC) suggesting the activation of…”
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Gain of chromosome arm 9p is characteristic of primary mediastinal b-cell lymphoma (MBL): Comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line by Bentz, Martin, Barth, Thomas F. E., Brüderlein, Silke, Bock, Daliah, Schwerer, Michael J., Baudis, Michael, Joos, Stefan, Viardot, Andreas, Feller, Alfred C., Müller-Hermelink, Hans-Konrad, Lichter, Peter, Döhner, Hartmut, Möller, Peter

“…Primary mediastinal B‐cell lymphoma (MBL) is an aggressive Non‐Hodgkin's Lymphoma, which has been recognized as a distinct disease entity. We performed a…”
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Recurrent Chromosomal Imbalances Detected in Biopsy Material from Oral Premalignant and Malignant Lesions by Combined Tissue Microdissection, Universal DNA Amplification, and Comparative Genomic Hybridization by Weber, Ruthild G., Scheer, Martin, Born, I. Antonio, Joos, Stefan, Cobbers, J. M. J. Ludwig, Hofele, Christof, Reifenberger, Guido, Zöller, Joachim E., Lichter, Peter

“…Biopsies routinely performed for the histopathological diagnosis of oral epithelial lesions before treatment were screened for chromosomal imbalances by…”
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