Search Results - "JONES, P. Simon"

Carrots and sticks fail to change behavior in cocaine addiction by Ersche, Karen D., Gillan, Claire M., Jones, P. Simon, Williams, Guy B., Ward, Laetitia H. E., Luijten, Maartje, de Wit, Sanne, Sahakian, Barbara J., Bullmore, Edward T., Robbins, Trevor W.

“…Cocaine addiction is a major public health problem that is particularly difficult to treat. Without medically proven pharmacological treatments, interventions…”
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Abnormal Brain Structure Implicated in Stimulant Drug Addiction by Ersche, Karen D., Jones, P. Simon, Williams, Guy B., Turton, Abigail J, Robbins, Trevor W., Bullmore, Edward T.

“…Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at…”
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Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes by Murley, Alexander G, Coyle-Gilchrist, Ian, Rouse, Matthew A, Jones, P Simon, Li, Win, Wiggins, Julie, Lansdall, Claire, Rodríguez, Patricia Vázquez, Wilcox, Alicia, Tsvetanov, Kamen A, Patterson, Karalyn, Lambon Ralph, Matthew A, Rowe, James B

“…The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous and overlapping clinical features. There has been great progress in the…”
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Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence by Ersche, Karen D., Barnes, Anna, Simon Jones, P., Morein-Zamir, Sharon, Robbins, Trevor W., Bullmore, Edward T.

“…A growing body of preclinical evidence indicates that addiction to cocaine is associated with neuroadaptive changes in frontostriatal brain systems. Human…”
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Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy by Cope, Thomas E, Rittman, Timothy, Borchert, Robin J, Jones, P Simon, Vatansever, Deniz, Allinson, Kieren, Passamonti, Luca, Vazquez Rodriguez, Patricia, Bevan-Jones, W Richard, O'Brien, John T, Rowe, James B

“…Prion-like, trans-neuronal spread of tau pathology in humans is controversial. By evaluating tau burden and functional connectivity in living patients, Cope et…”
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Microglial activation and tau burden predict cognitive decline in Alzheimer's disease by Malpetti, Maura, Kievit, Rogier A, Passamonti, Luca, Jones, P Simon, Tsvetanov, Kamen A, Rittman, Timothy, Mak, Elijah, Nicastro, Nicolas, Bevan-Jones, W Richard, Su, Li, Hong, Young T, Fryer, Tim D, Aigbirhio, Franklin I, O'Brien, John T, Rowe, James B

“…Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's disease. Understanding whether these features predict cognitive decline,…”
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[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia by Bevan-Jones, W R, Cope, Thomas E, Jones, P Simon, Passamonti, Luca, Hong, Young T, Fryer, Tim D, Arnold, Robert, Allinson, Kieren S J, Coles, Jonathan P, Aigbirhio, Franklin I, Patterson, Karalyn, O’Brien, John T, Rowe, James B

“…IntroductionSemantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43…”
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Synaptic Loss in Primary Tauopathies Revealed by [11C]UCB‐J Positron Emission Tomography by Holland, Negin, Jones, P. Simon, Savulich, George, Wiggins, Julie K., Hong, Young T., Fryer, Tim D., Manavaki, Roido, Sephton, Selena Milicevic, Boros, Istvan, Malpetti, Maura, Hezemans, Frank H., Aigbirhio, Franklin I., Coles, Jonathan P., O’Brien, John, Rowe, James B.

“…Background Synaptic loss is a prominent and early feature of many neurodegenerative diseases. Objectives We tested the hypothesis that synaptic density is…”
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Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease by Jones, Simon P, Franco, Nunzio F, Varney, Bianca, Sundaram, Gayathri, Brown, David A, de Bie, Josien, Lim, Chai K, Guillemin, Gilles J, Brew, Bruce J

“…The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the…”
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The effects of age on resting‐state BOLD signal variability is explained by cardiovascular and cerebrovascular factors by Tsvetanov, Kamen A., Henson, Richard N. A., Jones, P. Simon, Mutsaerts, Henk, Fuhrmann, Delia, Tyler, Lorraine K., Rowe, James B.

“…Accurate identification of brain function is necessary to understand neurocognitive aging, and thereby promote health and well‐being. Many studies of…”
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An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field by Ye, Rong, Rua, Catarina, O'Callaghan, Claire, Jones, P. Simon, Hezemans, Frank H., Kaalund, Sanne S., Tsvetanov, Kamen A., Rodgers, Christopher T., Williams, Guy, Passamonti, Luca, Rowe, James B.

“…Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention,…”
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Apathy and impulsivity in frontotemporal lobar degeneration syndromes by Lansdall, Claire J, Coyle-Gilchrist, Ian T S, Jones, P Simon, Vázquez Rodríguez, Patricia, Wilcox, Alicia, Wehmann, Eileen, Dick, Katrina M, Robbins, Trevor W, Rowe, James B

“…Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology…”
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Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy by Malpetti, Maura, Passamonti, Luca, Rittman, Timothy, Jones, P. Simon, Vázquez Rodríguez, Patricia, Bevan‐Jones, W. Richard, Hong, Young T., Fryer, Tim D., Aigbirhio, Franklin I., O'Brien, John T., Rowe, James B.

“…Objective We examined the relationship between tau pathology and neuroinflammation using [11C]PK11195 and [18F]AV‐1451 PET in 17 patients with progressive…”
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Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum by Bevan-Jones, W Richard, Cope, Thomas E, Jones, P Simon, Kaalund, Sanne S, Passamonti, Luca, Allinson, Kieren, Green, Oliver, Hong, Young T, Fryer, Tim D, Arnold, Robert, Coles, Jonathan P, Aigbirhio, Franklin I, Larner, Andrew J, Patterson, Karalyn, O'Brien, John T, Rowe, James B

“…The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common…”
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Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes by Murley, Alexander G, Rouse, Matthew A, Coyle-Gilchrist, Ian T S, Jones, P Simon, Li, Win, Wiggins, Julie, Lansdall, Claire, Vázquez Rodríguez, Patricia, Wilcox, Alicia, Patterson, Karalyn, Rowe, James B

“…ObjectiveTo test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional…”
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Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome by Holland, Negin, Savulich, George, Jones, P. Simon, Whiteside, David J., Street, Duncan, Swann, Peter, Naessens, Michelle, Malpetti, Maura, Hong, Young T., Fryer, Tim D., Rittman, Timothy, Mulroy, Eoin, Aigbirhio, Franklin I., Bhatia, Kailash P., O'Brien, John T., Rowe, James B.

“…Background/Objective The corticobasal syndrome (CBS) is a complex asymmetric movement disorder, with cognitive impairment. Although commonly associated with…”
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Does stroke location predict walk speed response to gait rehabilitation? by Jones, P. Simon, Pomeroy, Valerie M., Wang, Jasmine, Schlaug, Gottfried, Tulasi Marrapu, S., Geva, Sharon, Rowe, Philip J., Chandler, Elizabeth, Kerr, Andrew, Baron, Jean-Claude

“…Objectives Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and…”
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Synaptic Loss in Frontotemporal Dementia Revealed by [11C]UCB‐J Positron Emission Tomography by Malpetti, Maura, Jones, P. Simon, Cope, Thomas E., Holland, Negin, Naessens, Michelle, Rouse, Matthew A., Rittman, Timothy, Savulich, George, Whiteside, David J., Street, Duncan, Fryer, Tim D., Hong, Young T., Milicevic Sephton, Selena, Aigbirhio, Franklin I., O′Brien, John T., Rowe, James B.

“…Objective Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal…”
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Atomoxetine restores the response inhibition network in Parkinson's disease by Rae, Charlotte L, Nombela, Cristina, Rodríguez, Patricia Vázquez, Ye, Zheng, Hughes, Laura E, Jones, P Simon, Ham, Timothy, Rittman, Timothy, Coyle-Gilchrist, Ian, Regenthal, Ralf, Sahakian, Barbara J, Barker, Roger A, Robbins, Trevor W, Rowe, James B

“…Parkinson's disease impairs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse control disorders affect ∼10% of…”
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Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia by Malpetti, Maura, Cope, Thomas E, Street, Duncan, Jones, P Simon, Hezemans, Frank H, Mak, Elijah, Tsvetanov, Kamen A, Rittman, Timothy, Bevan-Jones, W Richard, Patterson, Karalyn, Passamonti, Luca, Fryer, Tim D, Hong, Young T, Aigbirhio, Franklin I, O’Brien, John T, Rowe, James B

“…Abstract Frontotemporal dementia is clinically and neuropathologically heterogeneous, but neuroinflammation, atrophy and cognitive impairment occur in all of…”
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