Search Results - "JONES, Nic"

Multiple pathways differentially regulate global oxidative stress responses in fission yeast by Chen, Dongrong, Wilkinson, Caroline R M, Watt, Stephen, Penkett, Christopher J, Toone, W Mark, Jones, Nic, Bähler, Jürg

“…Cellular protection against oxidative damage is relevant to ageing and numerous diseases. We analyzed the diversity of genome-wide gene expression programs and…”
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Global transcriptional responses of fission yeast to environmental stress by Chen, Dongrong, Toone, W Mark, Mata, Juan, Lyne, Rachel, Burns, Gavin, Kivinen, Katja, Brazma, Alvis, Jones, Nic, Bähler, Jürg

“…We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to…”
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JNK Suppresses Tumor Formation via a Gene-Expression Program Mediated by ATF2 by Gozdecka, Malgorzata, Lyons, Stephen, Kondo, Saki, Taylor, Janet, Li, Yaoyong, Walczynski, Jacek, Thiel, Gerald, Breitwieser, Wolfgang, Jones, Nic

“…JNK and p38 phosphorylate a diverse set of substrates and, consequently, can act in a context-dependent manner to either promote or inhibit tumor growth…”
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Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells by Breitwieser, Wolfgang, Lyons, Steve, Flenniken, Ann Marie, Ashton, Garry, Bruder, Gail, Willington, Mark, Lacaud, Georges, Kouskoff, Valerie, Jones, Nic

“…The ATF2 transcription factor is phosphorylated by the stress-activated mitogen-activated protein kinases (MAPKs) JNK and p38. We show that this…”
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A role for ATF2 in regulating MITF and melanoma development by Shah, Meera, Bhoumik, Anindita, Goel, Vikas, Dewing, Antimone, Breitwieser, Wolfgang, Kluger, Harriet, Krajewski, Stan, Krajewska, Maryla, Dehart, Jason, Lau, Eric, Kallenberg, David M, Jeong, Hyeongnam, Eroshkin, Alexey, Bennett, Dorothy C, Chin, Lynda, Bosenberg, Marcus, Jones, Nic, Ronai, Ze'ev A

“…The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models…”
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Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development by Ackermann, Julien, Ashton, Garry, Lyons, Steve, James, Dominic, Hornung, Jean-Pierre, Jones, Nic, Breitwieser, Wolfgang

“…The AP-1 family transcription factor ATF2 is essential for development and tissue maintenance in mammals. In particular, ATF2 is highly expressed and activated…”
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Suppressor role of activating transcription factor 2 (ATF2) in skin cancer by Bhoumik, Anindita, Fichtman, Boris, DeRossi, Charles, Breitwieser, Wolfgang, Kluger, Harriet M, Davis, Sean, Subtil, Antonio, Meltzer, Paul, Krajewski, Stan, Jones, Nic, Ronai, Ze'ev

“…Activating transcription factor 2 (ATF2) regulates transcription in response to stress and growth factor stimuli. Here, we use a mouse model in which ATF2 was…”
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Regulation of Schizosaccharomyces pombe Atf1 Protein Levels by Sty1-mediated Phosphorylation and Heterodimerization with Pcr1 by Lawrence, Clare L., Maekawa, Hiromi, Worthington, Jessica L., Reiter, Wolfgang, Wilkinson, Caroline R.M., Jones, Nic

“…The Atf1 transcription factor plays a vital role in the ability of Schizosaccharomyces pombe cells to respond to various stress conditions. It regulates the…”
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The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo by Verschuren, Emmy W., Klefstrom, Juha, Evan, Gerard I., Jones, Nic

“…Expression of the Kaposi's sarcoma-associated herpesvirus (KSHV) cyclin D homolog, K cyclin, is thought to contribute to viral oncogenesis. We show that K…”
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Distinct Regulatory Proteins Control the Graded Transcriptional Response to Increasing H2O2 Levels in Fission Yeast Schizosaccharomyces pombe by Quinn, Janet, Findlay, Victoria J., Dawson, Keren, Millar, Jonathan B.A., Jones, Nic, Morgan, Brian A., Toone, W. Mark

“…The signaling pathways that sense adverse stimuli and communicate with the nucleus to initiate appropriate changes in gene expression are central to the…”
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The Roles of Stress-Activated Sty1 and Gcn2 Kinases and of the Protooncoprotein Homologue Int6/eIF3e in Responses to Endogenous Oxidative Stress during Histidine Starvation by Nemoto, Naoki, Udagawa, Tsuyoshi, Ohira, Takahiro, Jiang, Li, Hirota, Kouji, Wilkinson, Caroline R.M., Bähler, Jürg, Jones, Nic, Ohta, Kunihiro, Wek, Ronald C., Asano, Katsura

“…In fission yeast, Sty1 and Gcn2 are important protein kinases that regulate gene expression in response to amino acid starvation. The translation factor…”
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Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration by Vivancos, Ana P., Castillo, Esther A., Jones, Nic, Ayté, José, Hidalgo, Elena

“…Summary The transcription factor Pap1 and the MAP kinase Sty1 are key regulators of hydrogen peroxide‐induced responses in Schizosaccharomyces pombe. Pap1 can…”
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Redox control of AP-1-like factors in yeast and beyond: AP-1 by TOONE, W. Mark, MORGAN, Brian A, JONES, Nic

“…Cells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses is the…”
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Distinct Roles for Glutathione S-Transferases in the Oxidative Stress Response in Schizosaccharomyces pombe by Veal, Elizabeth A, Toone, W Mark, Jones, Nic, Morgan, Brian A

“…We have identified three genes, gst1 + , gst2 + , and gst3 + , encoding θ-class glutathione S -transferases (GSTs) in Schizosaccharomyces pombe . The gst1 +…”
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Fission Yeast MAP Kinase Sty1 Is Recruited to Stress-induced Genes by Reiter, Wolfgang, Watt, Stephen, Dawson, Keren, Lawrence, Clare L., Bähler, Jürg, Jones, Nic, Wilkinson, Caroline R.M.

“…The stress-induced expression of many fission yeast genes is dependent upon the Sty1 mitogen-activated protein kinase (MAPK) and Atf1 transcription factor…”
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Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53 by Maehara, Kayoko, Yamakoshi, Kimi, Ohtani, Naoko, Kubo, Yoshiaki, Takahashi, Akiko, Arase, Seiji, Jones, Nic, Hara, Eiji

“…E2F/DP complexes were originally identified as potent transcriptional activators required for cell proliferation. However, recent studies revised this notion…”
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Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1 by Toone, W M, Kuge, S, Samuels, M, Morgan, B A, Toda, T, Jones, N

“…The fission yeast Sty1 stress-activated MAP kinase is crucial for the cellular response to a variety of stress conditions. Accordingly, sty1- cells are…”
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The Transcription Factor Atf1 Binds and Activates the APC/C Ubiquitin Ligase in Fission Yeast by Ors, Aslihan, Grimaldi, Margaret, Kimata, Yuu, Wilkinson, Caroline R.M., Jones, Nic, Yamano, Hiroyuki

“…Fission yeast Atf1 is a member of the ATF/CREB basic leucine zipper (bZIP) family of transcription factors with strong homology to mammalian ATF2. Atf1…”
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Int6/eIF3e Promotes General Translation and Atf1 Abundance to Modulate Sty1 MAPK-dependent Stress Response in Fission Yeast by Udagawa, Tsuyoshi, Nemoto, Naoki, Wilkinson, Caroline R.M., Narashimhan, Jana, Jiang, Li, Watt, Stephen, Zook, Aaron, Jones, Nic, Wek, Ronald C., Bähler, Jürg, Asano, Katsura

“…int-6 is one of the frequent integration sites for mouse mammary tumor viruses. Although its product is the e-subunit of translation initiation factor eIF3,…”
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Transcriptional Switch by Activating Transcription Factor 2-Derived Peptide Sensitizes Melanoma Cells to Apoptosis and Inhibits Their Tumorigenicity by Bhoumik, Anindita, Jones, Nic, Ze'ev Ronai, Lerner, Aaron B.

“…The notorious resistance of melanoma cells to drug treatment can be overcome by expression of a 50-aa peptide derived from activating transcription factor 2 (…”
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