Search Results - "JONES, J. Louise"

Jekyll and Hyde: the role of the microenvironment on the progression of cancer by Allen, Michael, Louise Jones, J

“…It is now recognized that the host microenvironment undergoes extensive change during the evolution and progression of cancer. This involves the generation of…”
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Field cancerization in breast cancer by Gadaleta, Emanuela, Thorn, Graeme J, Ross‐Adams, Helen, Jones, Louise J, Chelala, Claude

“…Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early…”
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Prognostic and Predictive Value of HER2 Expression in Ductal Carcinoma In Situ: Results from the UK/ANZ DCIS Randomized Trial by Thorat, Mangesh A, Levey, Pauline M, Jones, J Louise, Pinder, Sarah E, Bundred, Nigel J, Fentiman, Ian S, Cuzick, Jack

“…HER2 is overexpressed more frequently in ductal carcinoma in situ (DCIS) than in invasive breast cancer but its prognostic significance and predictive role for…”
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Hard X-ray dark-field imaging with incoherent sample illumination by Endrizzi, Marco, Diemoz, Paul C., Millard, Thomas P., Louise Jones, J., Speller, Robert D., Robinson, Ian K., Olivo, Alessandro

“…We report on a non-interferometric technique enabling dark-field imaging by using incoherent illumination and two achromatic optical elements. The simultaneous…”
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Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers by Pearce, Oliver M T, Delaine-Smith, Robin M, Maniati, Eleni, Nichols, Sam, Wang, Jun, Böhm, Steffen, Rajeeve, Vinothini, Ullah, Dayem, Chakravarty, Probir, Jones, Roanne R, Montfort, Anne, Dowe, Tom, Gribben, John, Jones, J Louise, Kocher, Hemant M, Serody, Jonathan S, Vincent, Benjamin G, Connelly, John, Brenton, James D, Chelala, Claude, Cutillas, Pedro R, Lockley, Michelle, Bessant, Conrad, Knight, Martin M, Balkwill, Frances R

“…We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine…”
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PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression by Chiang, Kelly, Zielinska, Agnieszka E., Shaaban, Abeer M., Sanchez-Bailon, Maria Pilar, Jarrold, James, Clarke, Thomas L., Zhang, Jingxian, Francis, Adele, Jones, Louise J., Smith, Sally, Barbash, Olena, Guccione, Ernesto, Farnie, Gillian, Smalley, Matthew J., Davies, Clare C.

“…Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs)…”
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Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors by Saunderson, Emily A., Stepper, Peter, Gomm, Jennifer J., Hoa, Lily, Morgan, Adrienne, Allen, Michael D., Jones, J. Louise, Gribben, John G., Jurkowski, Tomasz P., Ficz, Gabriella

“…Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To…”
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Prognostic Value of ER and PgR Expression and the Impact of Multi-clonal Expression for Recurrence in Ductal Carcinoma in situ : Results from the UK/ANZ DCIS Trial by Thorat, Mangesh A, Levey, Pauline M, Jones, J Louise, Pinder, Sarah E, Bundred, Nigel J, Fentiman, Ian S, Cuzick, Jack

“…The prognostic value of estrogen receptor (ER)/progesterone receptor (PgR) expression in ductal carcinoma (DCIS) is unclear. We observed multi-clonality when…”
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Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography by Massimi, Lorenzo, Suaris, Tamara, Hagen, Charlotte K., Endrizzi, Marco, Munro, Peter R. T., Havariyoun, Glafkos, Hawker, P. M. Sam, Smit, Bennie, Astolfo, Alberto, Larkin, Oliver J., Waltham, Richard M., Shah, Zoheb, Duffy, Stephen W., Nelan, Rachel L., Peel, Anthony, Jones, J. Louise, Haig, Ian G., Bate, David, Olivo, Alessandro

“…Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations…”
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ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation by Gibson, Shayin V., Madzharova, Elizabeta, Tan, Amandine C., Allen, Michael D., Keller, Ulrich auf dem, Louise Jones, J., Carter, Edward P., Grose, Richard P.

“…•Metzincins display both pro- and anti-invasive effects in breast cancer.•Loss of myoepithelial ADAMTS3 expression drives invasion.•Degradomic analysis…”
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The Future of Precision Oncology by Rulten, Stuart L, Grose, Richard P, Gatz, Susanne A, Jones, J. Louise, Cameron, Angus J. M

“…Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one…”
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Volumetric High-Resolution X-Ray Phase-Contrast Virtual Histology of Breast Specimens With a Compact Laboratory System by Massimi, Lorenzo, Suaris, Tamara, Hagen, Charlotte K., Endrizzi, Marco, Munro, Peter R. T., Havariyoun, Glafkos, Hawker, P. M. Sam, Smit, Bennie, Astolfo, Alberto, Larkin, Oliver J., Waltham, Richard M., Shah, Zoheb, Duffy, Stephen W., Nelan, Rachel L., Peel, Anthony, Jones, J. Louise, Haig, Ian G., Bate, David, Olivo, Alessandro

“…The assessment of margin involvement is a fundamental task in breast conserving surgery to prevent recurrences and reoperations. It is usually performed…”
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Development of a Validated Exam to Assess Pathologist Knowledge of Genomic Oncology by Haspel, Richard L, Jones, J Louise, Rizvi, Hasan, Young, Martin

“…There is a clear need to educate health professionals in genomic medicine. Pathologists, given their critical role in cancer diagnostics, must understand core…”
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Stromal characteristics may hold the key to mammographic density: the evidence to date by Ironside, Alastair J, Jones, J Louise

“…There is strong epidemiological data indicating a role for increased mammographic density (MD) in predisposing to breast cancer, however, the biological…”
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The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis by Clarke, Cassie J., Berg, Tracy J., Birch, Joanna, Ennis, Darren, Mitchell, Louise, Cloix, Catherine, Campbell, Andrew, Sumpton, David, Nixon, Colin, Campbell, Kirsteen, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Jones, J. Louise, Haywood, Linda, Pulleine, Ellie, Yin, Huabing, Strathdee, Douglas, Sansom, Owen, Blyth, Karen, McNeish, Iain, Zanivan, Sara, Reynolds, Andrew R., Norman, Jim C.

“…Expression of the initiator methionine tRNA (tRNAiMet) is deregulated in cancer. Despite this fact, it is not currently known how tRNAiMet expression levels…”
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A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences by Shaaban, Abeer M., Ball, Graham R., Brannan, Rebecca A., Cserni, Gabor, Benedetto, Anna Di, Dent, Jo, Fulford, Laura, Honarpisheh, Helen, Jordan, Lee, Jones, J. Louise, Kanthan, Rani, Maraqa, Loaie, Litwiniuk, Maria, Mottolese, Marcella, Pollock, Steven, Provenzano, Elena, Quinlan, Philip R., Reall, Georgina, Shousha, Sami, Stephens, Mark, Verghese, Eldo T., Walker, Rosemary A., Hanby, Andrew M., Speirs, Valerie

“…Male breast cancer remains understudied despite evidence of rising incidence. Using a co-ordinated multi-centre approach, we present the first large scale…”
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A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer by Carter, Edward P, Gopsill, James A, Gomm, Jennifer J, Jones, J Louise, Grose, Richard P

“…3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue…”
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Rigidity sensing and adaptation through regulation of integrin types by Elosegui-Artola, Alberto, Bazellières, Elsa, Allen, Michael D., Andreu, Ion, Oria, Roger, Sunyer, Raimon, Gomm, Jennifer J., Marshall, John F., Jones, J. Louise, Trepat, Xavier, Roca-Cusachs, Pere

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PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer by Fearon, Abbie E., Carter, Edward P., Clayton, Natasha S., Wilkes, Edmund H., Baker, Ann-Marie, Kapitonova, Ekaterina, Bakhouche, Bakhouche A., Tanner, Yasmine, Wang, Jun, Gadaleta, Emanuela, Chelala, Claude, Moore, Kate M., Marshall, John F., Chupin, Juliette, Schmid, Peter, Jones, J. Louise, Lockley, Michelle, Cutillas, Pedro R., Grose, Richard P.

“…Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine…”
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Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion by Gutiérrez-Fernández, Ana, Fueyo, Antonio, Folgueras, Alicia R, Garabaya, Cecilia, Pennington, Caroline J, Pilgrim, Simon, Edwards, Dylan R, Holliday, Deborah L, Jones, J Louise, Span, Paul N, Sweep, Fred C G J, Puente, Xose S, López-Otín, Carlos

“…Collagenase-2 (matrix metalloproteinase-8, MMP-8) is an MMP mainly produced by neutrophils and associated with many inflammatory conditions. We have previously…”
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