Search Results - "JOHNSTON, COLIN I"

Myocardial infarction increases ACE2 expression in rat and humans by Burrell, Louise M., Risvanis, John, Kubota, Eiji, Dean, Rachael G., MacDonald, Peter S., Lu, Sai, Tikellis, Christos, Grant, Sharon L., Lew, Rebecca A., Smith, A. Ian, Cooper, Mark E., Johnston, Colin I.

“…Aims Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I to Ang 1‐9 and of Ang II to Ang 1‐7. ACE2 deficiency impairs cardiac…”
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ACE2, a new regulator of the renin–angiotensin system by Burrell, Louise M., Johnston, Colin I., Tikellis, Christos, Cooper, Mark E.

“…Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin–angiotensin system (RAS). ACE2 is a newly described enzyme…”
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Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes by JANDELEIT-DAHM, Karin A. M, TIKELLIS, Christos, REID, Christopher M, JOHNSTON, Colin I, COOPER, Mark E

“…Recent trials have suggested that inhibitors of the renin-angiotensin system (RAS), such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin II…”
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Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy by Tikellis, Christos, Johnston, Colin I, Forbes, Josephine M, Burns, Wendy C, Burrell, Louise M, Risvanis, John, Cooper, Mark E

“…ABSTRACT—ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-converting enzyme (ACE) but contains only a single…”
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Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly by McNeil, John J, Wolfe, Rory, Woods, Robyn L, Tonkin, Andrew M, Donnan, Geoffrey A, Nelson, Mark R, Reid, Christopher M, Lockery, Jessica E, Kirpach, Brenda, Storey, Elsdon, Shah, Raj C, Williamson, Jeff D, Margolis, Karen L, Ernst, Michael E, Abhayaratna, Walter P, Stocks, Nigel, Fitzgerald, Sharyn M, Orchard, Suzanne G, Trevaks, Ruth E, Beilin, Lawrence J, Johnston, Colin I, Ryan, Joanne, Radziszewska, Barbara, Jelinek, Michael, Malik, Mobin, Eaton, Charles B, Brauer, Donna, Cloud, Geoff, Wood, Erica M, Mahady, Suzanne E, Satterfield, Suzanne, Grimm, Richard, Murray, Anne M

“…In older persons without known cardiovascular disease, the use of low-dose aspirin resulted in a significantly higher risk of major hemorrhage and did not…”
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Effect of Aspirin on All-Cause Mortality in the Healthy Elderly by McNeil, John J, Nelson, Mark R, Woods, Robyn L, Lockery, Jessica E, Wolfe, Rory, Reid, Christopher M, Kirpach, Brenda, Shah, Raj C, Ives, Diane G, Storey, Elsdon, Ryan, Joanne, Tonkin, Andrew M, Newman, Anne B, Williamson, Jeff D, Margolis, Karen L, Ernst, Michael E, Abhayaratna, Walter P, Stocks, Nigel, Fitzgerald, Sharyn M, Orchard, Suzanne G, Trevaks, Ruth E, Beilin, Lawrence J, Donnan, Geoffrey A, Gibbs, Peter, Johnston, Colin I, Radziszewska, Barbara, Grimm, Richard, Murray, Anne M

“…After a median follow-up of 4.7 years, there were 1.6 more deaths per 1000 person-years among healthy older adults who were randomly assigned to receive…”
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Effect of Aspirin on Disability-free Survival in the Healthy Elderly by McNeil, John J, Woods, Robyn L, Nelson, Mark R, Reid, Christopher M, Kirpach, Brenda, Wolfe, Rory, Storey, Elsdon, Shah, Raj C, Lockery, Jessica E, Tonkin, Andrew M, Newman, Anne B, Williamson, Jeff D, Margolis, Karen L, Ernst, Michael E, Abhayaratna, Walter P, Stocks, Nigel, Fitzgerald, Sharyn M, Orchard, Suzanne G, Trevaks, Ruth E, Beilin, Lawrence J, Donnan, Geoffrey A, Gibbs, Peter, Johnston, Colin I, Ryan, Joanne, Radziszewska, Barbara, Grimm, Richard, Murray, Anne M

“…In a trial comparing 100 mg of aspirin with placebo in nearly 20,000 community-dwelling persons 70 years of age or older in Australia and the United States,…”
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Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats by YU, H. C. M, BURRELL, L. M, BLACK, M. J, WU, L. L, DILLEY, R. J, COOPER, M. E, JOHNSTON, C. I

“…The detrimental effects of high dietary salt intake may not only involve effects on blood pressure and organ hypertrophy but also lead to tissue fibrosis…”
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Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study by McNeil, John J, Woods, Robyn L, Nelson, Mark R, Murray, Anne M, Reid, Christopher M, Kirpach, Brenda, Storey, Elsdon, Shah, Raj C, Wolfe, Rory S, Tonkin, Andrew M, Newman, Anne B, Williamson, Jeff D, Lockery, Jessica E, Margolis, Karen L, Ernst, Michael E, Abhayaratna, Walter P, Stocks, Nigel, Fitzgerald, Sharyn M, Trevaks, Ruth E, Orchard, Suzanne G, Beilin, Lawrence J, Donnan, Geoffrey A, Gibbs, Peter, Johnston, Colin I, Grimm, Richard H

“…There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a…”
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Eulogy John Ludbrook: Surgeon, physiologist and biostatistician by Evans, Roger G., Johnston, Colin I.

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High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage by BERNARDI, Stella, TOFFOLI, Barbara, JOHNSTON, Colin I, FABRIS, Bruno, ZENNARO, Cristina, TIKELLIS, Christos, MONTICONE, Silvia, LOSURDO, Pasquale, BELLINI, Giuseppe, THOMAS, Merlin C, FALLO, Francesco, VEGLIO, Franco

“…Angiotensin II (AngII) contributes to salt-driven kidney damage. In this study, we aimed at investigating whether and how the renal damage associated with a…”
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A Comparison of Outcomes with Angiotensin-Converting–Enzyme Inhibitors and Diuretics for Hypertension in the Elderly by Wing, Lindon M.H, Reid, Christopher M, Ryan, Philip, Beilin, Lawrence J, Brown, Mark A, Jennings, Garry L.R, Johnston, Colin I, McNeil, John J, Macdonald, Graham J, Marley, John E, Morgan, Trefor O, West, Malcolm J

“…This prospective, open-label, randomized study compared the outcomes in hypertensive subjects 65 to 84 years of age who received therapy with…”
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Localization of angiotensin-converting enzyme in the human prostate: pathological expression in benign prostatic hyperplasia by Nassis, Labrini, Frauman, Albert G., Ohishi, Mitsuru, Zhuo, Jialong, Casley, David J., Johnston, Colin I., Fabiani, Maurice E.

“…Benign prostatic hyperplasia (BPH) is the most common hyperplastic disease in man and it is characterized by increased cellular growth (stromal and epithelial…”
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Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study by Chowdhury, Enayet K, Nelson, Mark R, Ernst, Michael E, Margolis, Karen L, Beilin, Lawrence J, Johnston, Colin I, Woods, Robyn L, Murray, Anne M, Wolfe, Rory, Storey, Elsdon, Shah, Raj C, Lockery, Jessica E, Tonkin, Andrew M, Newman, Anne B, Williamson, Jeff D, Abhayaratna, Walter P, Stocks, Nigel P, Fitzgerald, Sharyn M, Orchard, Suzanne G, Trevaks, Ruth E, Donnan, Geoffrey A, Grimm, Richard, McNeil, John J, Reid, Christopher M

“…Abstract BACKGROUND Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in…”
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Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study by McNeil, John J, Woods, Robyn L, Nelson, Mark R, Murray, Anne M, Reid, Christopher M, Kirpach, Brenda, Storey, Elsdon, Shah, Raj C, Wolfe, Rory S, Tonkin, Andrew M, Newman, Anne B, Williamson, Jeff D, Lockery, Jessica E, Margolis, Karen L, Ernst, Michael E, Abhayaratna, Walter P, Stocks, Nigel, Fitzgerald, Sharyn M, Trevaks, Ruth E, Orchard, Suzanne G, Beilin, Lawrence J, Donnan, Geoffrey A, Gibbs, Peter, Johnston, Colin I, Grimm, Richard H

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Short- and Long-Term Survival in Treated Elderly Hypertensive Patients With or Without Diabetes: Findings From the Second Australian National Blood Pressure Study by Chowdhury, Enayet K., Owen, Alice, Ademi, Zanfina, Krum, Henry, Johnston, Colin I., Wing, Lindon M.H., Nelson, Mark R., Reid, Christopher M.

“…BACKGROUND We sought to determine the incidence of newly diagnosed diabetes in treated elderly hypertensive patients and the prognostic impact of diabetes on…”
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Brachial Blood Pressure But Not Carotid Arterial Waveforms Predict Cardiovascular Events in Elderly Female Hypertensives by Dart, Anthony M, Gatzka, Christoph D, Kingwell, Bronwyn A, Willson, Kristyn, Cameron, James D, Liang, Yu-Lu, Berry, Karen L, Wing, Lindon M.H, Reid, Christopher M, Ryan, Philip, Beilin, Lawrence J, Jennings, Garry L.R, Johnston, Colin I, McNeil, John J, MacDonald, Graham J, Morgan, Trefor O, West, Malcolm J

“…Central arterial waveforms and related indices of large artery properties can be determined with relative ease. This would make them an attractive adjunct in…”
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Feasibility of conducting a primary prevention trial of low‐dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study by Nelson, Mark R, Reid, Christopher M, Ames, David, Beilin, Lawrence J, Donnan, Geoffrey A, Gibbs, Peter, Johnston, Colin I, Krum, Henry, Storey, Elsdon, Tonkin, Andrew, Wolfe, Rory, Woods, Robyn, McNeil, John J

“…Aim: To determine the feasibility of performing a large clinical trial of the use of aspirin for the primary prevention of cardiovascular disease in older…”
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Vasopressin receptor antagonism — a therapeutic option in heart failure and hypertension by Burrell, Louise M., Risvanis, John, Johnston, Colin I., Naitoh, Mareo, Balding, Leanne C.

“…The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons…”
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Angiotensin receptors: distribution, signalling and function by Dinh, D T, Frauman, A G, Johnston, C I, Fabiani, M E

“…Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang…”
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