Search Results - "JOHNSON, PETER M."

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection by Beers, Stephen A., French, Ruth R., Chan, H.T. Claude, Lim, Sean H., Jarrett, Timothy C., Vidal, Regina Mora, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyungjin, Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.

“…Rituximab, a monoclonal antibody that targets CD20 on B cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this…”
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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy by Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.

“…The anti-CD20 mAb rituximab is central to the treatment of B-cell malignancies, but resistance remains a significant problem. We recently reported that…”
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Molecular layer-by-layer deposition of highly crosslinked polyamide films by Johnson, Peter M., Yoon, Joonsung, Kelly, Jennifer Y., Howarter, John A., Stafford, Christopher M.

“…A molecular layer‐by‐layer (mLbL) deposition process is demonstrated to synthesize conformal coatings of crosslinked polyamide. This process controls the rapid…”
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S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition by Hayden, Annette, Johnson, Peter W. M., Packham, Graham, Crabb, Simon J.

“…Epigenetic abnormalities including abnormal histone methyltransferase activity contribute to breast cancer pathogenesis. An example is over expression of the…”
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Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma by Birts, Charles N., Savva, Constantinos, Laversin, Stéphanie A., Lefas, Alicia, Krishnan, Jamie, Schapira, Aron, Ashton-Key, Margaret, Crispin, Max, Johnson, Peter W. M., Blaydes, Jeremy P., Copson, Ellen, Cutress, Ramsey I., Beers, Stephen A.

“…Obesity can initiate, promote, and maintain systemic inflammation via metabolic reprogramming of macrophages that encircle adipocytes, termed crown-like…”
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IL-4 enhances expression and function of surface IgM in CLL cells by Aguilar-Hernandez, Maria M., Blunt, Matthew D., Dobson, Rachel, Yeomans, Alison, Thirdborough, Stephen, Larrayoz, Marta, Smith, Lindsay D., Linley, Adam, Strefford, Jonathan C., Davies, Andrew, Johnson, Peter M.W., Savelyeva, Natalia, Cragg, Mark S., Forconi, Francesco, Packham, Graham, Stevenson, Freda K., Steele, Andrew J.

“…Kinase inhibitors targeting the B-cell receptor (BCR) are now prominent in the treatment of chronic lymphocytic leukemia (CLL). We have focused here on…”
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Mechanistic elucidation of the molecular weight dependence of corrosion inhibition afforded by polyetherimide coatings by Sill, Tiffany E., Ponce, Victor, Larriuz, Carlos, Chertakovsky, Ron, Valdes, Caroline G., Fletcher, Torrick, Nielsen, Jakob, Fuller, Kerry, Castaneda, Homero, Davidson, Rachel D., Johnson, Peter M., Banerjee, Sarbajit

“…Corrosion of critical metal components exacts a heavy toll in terms of maintenance and replacement costs and damage to ecosystems upon failure. Polymeric…”
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Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study by Hippisley-Cox, Julia, Coupland, Carol Ac, Mehta, Nisha, Keogh, Ruth H, Diaz-Ordaz, Karla, Khunti, Kamlesh, Lyons, Ronan A, Kee, Frank, Sheikh, Aziz, Rahman, Shamim, Valabhji, Jonathan, Harrison, Ewen M, Sellen, Peter, Haq, Nazmus, Semple, Malcolm G, Johnson, Peter W M, Hayward, Andrew, Nguyen-Van-Tam, Jonathan S

“…To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses…”
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RIVA - a phase IIa study of rituximab and varlilumab in relapsed or refractory B-cell malignancies: study protocol for a randomized controlled trial by Lim, Sean H, Linton, Kim M, Collins, Graham P, Dhondt, Joke, Caddy, Joshua, Rossiter, Liz, Vadher, Karan, Fines, Keira, Rogers, Laura E, Fernando, Diana, Stanton, Louise, Davies, Andrew J, Johnson, Peter W M, Griffiths, Gareth

“…Over 12,000 new cases of B-cell malignancies are diagnosed in the UK each year, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being…”
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Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit by Cucco, Francesco, Barrans, Sharon, Sha, Chulin, Clipson, Alexandra, Crouch, Simon, Dobson, Rachel, Chen, Zi, Thompson, Joe Sneath, Care, Matthew A., Cummin, Thomas, Caddy, Josh, Liu, Hongxiang, Robinson, Anne, Schuh, Anna, Fitzgibbon, Jude, Painter, Daniel, Smith, Alexandra, Roman, Eve, Tooze, Reuben, Burton, Catherine, Davies, Andrew J., Westhead, David R., Johnson, Peter W. M., Du, Ming-Qing

“…Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell…”
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Optimizing therapy in advanced-stage Hodgkin lymphoma by Lim, Sean H., Johnson, Peter W.M.

“…The treatment of Hodgkin lymphoma has evolved continuously since the introduction of extended-field radiotherapy in the 1960s to involved-field and then…”
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Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma by Ceriani, Luca, Martelli, Maurizio, Zinzani, Pier Luigi, Ferreri, Andrés J.M., Botto, Barbara, Stelitano, Caterina, Gotti, Manuel, Cabras, Maria Giuseppina, Rigacci, Luigi, Gargantini, Livio, Merli, Francesco, Pinotti, Graziella, Mannina, Donato, Luminari, Stefano, Stathis, Anastasios, Russo, Eleonora, Cavalli, Franco, Giovanella, Luca, Johnson, Peter W.M., Zucca, Emanuele

“…The International Extranodal Lymphoma Study Group (IELSG) 26 study was designed to evaluate the role of 18F-fluorodeoxyglucose (18FDG) positron emission…”
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[18F] Fluorodeoxyglucose Positron Emission Tomography Predicts Survival After Chemoimmunotherapy for Primary Mediastinal Large B-Cell Lymphoma: Results of the International Extranodal Lymphoma Study Group IELSG-26 Study by MARTELLI, Maurizio, CERIANI, Luca, BALZAROTTI, Monica, SALVI, Flavia, MONTOTO, Silvia, LOPEZ-GUILLERMO, Armando, FINOLEZZI, Erica, PILERI, Stefano A, DAVIES, Andrew, CAVALLI, Franco, GIOVANELLA, Luca, JOHNSON, Peter W. M, ZUCCA, Emanuele, ZINZANI, Pier Luigi, FERRERI, Andrés J. M, VITOLO, Umberto, STELITANO, Caterina, BRUSAMOLINO, Ercole, CABRAS, Maria Giuseppina, RIGACCI, Luigi

“…To assess the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) after rituximab and anthracycline-containing…”
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Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A by Crabb, Simon J., Howell, Melanie, Rogers, Helen, Ishfaq, Muhammad, Yurek-George, Alexander, Carey, Krystle, Pickering, Becky M., East, Phil, Mitter, Richard, Maeda, Satoko, Johnson, Peter W.M., Townsend, Paul, Shin-ya, Kazuo, Yoshida, Minoru, Ganesan, A., Packham, Graham

“…We recently completed the total synthesis of spiruchostatin A, a depsipeptide natural product with close structural similarities to FK228, a histone…”
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Dynamic resolution of acrosomal exocytosis in human sperm by Harper, Claire V, Cummerson, Joanne A, White, Michael R.H, Publicover, Stephen J, Johnson, Peter M

“…An essential step in mammalian fertilisation is the sperm acrosome reaction (AR) - exocytosis of a single large vesicle (the acrosome) that surrounds the…”
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Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential by Zhang, Chunye, Stelloo, Ellen, Barrans, Sharon, Cucco, Francesco, Jiang, Dan, Tzioni, Maria-Myrsini, Chen, Zi, Li, Yan, Swennenhuis, Joost F., Makker, Jasmine, Rásó-Barnett, Lívia, Liu, Hongxiang, El-Daly, Hesham, Soilleux, Elizabeth, Shah, Nimish, Nagumantry, Sateesh Kumar, Kyaw, Maw, Prahladan, Mahesh Panatt, Tooze, Reuben, Westhead, David R., Feitsma, Harma, Davies, Andrew J., Burton, Catherine, Johnson, Peter W. M., Du, Ming-Qing

“…MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or…”
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function by Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

“…The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and…”
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Epigenetics of Indolent Lymphoma and How It Drives Novel Therapeutic Approaches—Focus on EZH2-Targeted Drugs by Longley, Jemma, Johnson, Peter W. M.

“…Purpose of Review Epigenetic modifier gene mutations are common in patients with follicular lymphoma. Here we review the pathogenesis of these mutations and…”
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XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression by Fisher, Jack G., Doyle, Amber D. P., Graham, Lara V., Sonar, Shreyanshi, Sale, Ben, Henderson, Isla, Del Rio, Luis, Johnson, Peter W. M., Landesman, Yosef, Cragg, Mark S., Forconi, Francesco, Walker, Christopher J., Khakoo, Salim. I., Blunt, Matthew D.

“…The first-in-class inhibitor of exportin-1 (XPO1) selinexor is currently under clinical investigation in combination with the BTK inhibitor ibrutinib for…”
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Obesity Is Associated with Immunometabolic Changes in Adipose Tissue That May Drive Treatment Resistance in Breast Cancer: Immune-Metabolic Reprogramming and Novel Therapeutic Strategies by Savva, Constantinos, Copson, Ellen, Johnson, Peter W M, Cutress, Ramsey I, Beers, Stephen A

“…White adipose tissue (WAT) represents an endocrinologically and immunologically active tissue whose primary role is energy storage and homeostasis. Breast WAT…”
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