Search Results - "JOHNSON, Joseph O"

Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation by Liu, Qian, Adhikari, Emma, Lester, Daniel K., Fang, Bin, Johnson, Joseph O., Tian, Yijun, Mockabee-Macias, Andrea T., Izumi, Victoria, Guzman, Kelly M., White, Michael G., Koomen, John M., Wargo, Jennifer A., Messina, Jane L., Qi, Jianfei, Lau, Eric K.

“…Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male…”
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Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes by Ward, Grace A, Dalton, 3rd, Robert P, Meyer, Benjamin S, McLemore, Amy F, Aldrich, Amy L, Lam, Nghi B, Onimus, Alexis H, Vincelette, Nicole D, Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R, Christiansen, Sean M, Hou, Hsin-An, Johnson, Joseph O, Wright, Kenneth L, Padron, Eric, Eksioglu, Erika A, List, Alan F

“…Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome…”
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Preferential drug delivery to tumor cells than normal cells using a tunable niosome–chitosan double package nanodelivery system: a novel in vitro model by Wiranowska, Marzenna, Singh, Rupin, Falahat, Rana, Williams, Eva, Johnson, Joseph O., Alcantar, Norma

“…Background We previously described the properties of a targeted drug delivery system (DDS) in a cell-free system. Here, in this comparative cell-based study…”
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Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers by Rivera-Rivera, Yainyrette, Vargas, Geraldine, Jaiswal, Neha, Núñez-Marrero, Angel, Li, Jiannong, Chen, Dung-Tsa, Eschrich, Steven, Rosa, Marilin, Johnson, Joseph O, Dutil, Julie, Chellappan, Srikumar P, Saavedra, Harold I

“…Molecular epidemiology evidence indicates racial and ethnic differences in the aggressiveness and survival of breast cancer. Hispanics/Latinas (H/Ls) and…”
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Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors by McGraw, Kathy L, Basiorka, Ashley A, Johnson, Joseph O, Clark, Justine, Caceres, Gisela, Padron, Eric, Heaton, Ruth, Ozawa, Yukiyasu, Wei, Sheng, Sokol, Lubomir, List, Alan F

“…Anemia remains the principal management challenge for patients with lower risk Myelodysplastic Syndromes (MDS). Despite appropriate cytokine production and…”
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Erythropoietin receptor signaling is membrane raft dependent by McGraw, Kathy L, Fuhler, Gwenny M, Johnson, Joseph O, Clark, Justine A, Caceres, Gisela C, Sokol, Lubomir, List, Alan F

“…Upon erythropoietin (Epo) engagement, Epo-receptor (R) homodimerizes to activate JAK2 and Lyn, which phosphorylate STAT5. Although recent investigations have…”
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Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair by Velkova, Aneliya, Carvalho, Marcelo A., Johnson, Joseph O., Tavtigian, Sean V., Monteiro, Alvaro N.A.

“…The product of the breast and ovarian cancer susceptibility gene BRCA1 has been implicated in several aspects of the DNA damage response but its biochemical…”
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Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma by Wiranowska, Marzenna, Colina, Lucrecia O, Johnson, Joseph O

“…Chlorotoxin (TM601), a scorpion venom- derived 36-AA peptide, is an experimental drug against recurrent glioma with tumor specificity but unknown route of…”
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Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas by Beato, Francisca, Reverón, Dayana, Dezsi, Kaleena B., Ortiz, Antonio, Johnson, Joseph O., Chen, Dung-Tsa, Ali, Karla, Yoder, Sean J., Jeong, Daniel, Malafa, Mokenge, Hodul, Pamela, Jiang, Kun, Centeno, Barbara A., Abdalah, Mahmoud A., Balasi, Jodi A., Tassielli, Alexandra F., Sarcar, Bhaswati, Teer, Jamie K., DeNicola, Gina M., Permuth, Jennifer B., Fleming, Jason B.

“…Pancreatic cancer (PaCa) is the third leading cause of cancer-related deaths in the United States. There is an unmet need to develop strategies to detect PaCa…”
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Oncolytic immunotherapy with nivolumab in muscle-invasive bladder cancer: a phase 1b trial by Li, Roger, Villa, Nancy Y., Yu, Xiaoqing, Johnson, Joseph O., Borjas, Gustavo, Dhillon, Jasreman, Moran-Segura, Carlos M., Kim, Youngchul, Francis, Natasha, Dorman, Denise, Powers, John J., Sexton, Wade J., Spiess, Philippe E., Poch, Michael A., Zemp, Logan, Gilbert, Scott M., Zhang, Jingsong, Pow-Sang, Julio M., Anderson, Alexander R. A., Li, Tingyi, Wang, Xuefeng, Grass, G. Daniel, Burke, James M., Dinney, Colin P. N., Rodriguez, Paulo C., Jain, Rohit K., Mulé, James J., Conejo-Garcia, Jose R.

“…There is a critical unmet need for safe and efficacious neoadjuvant treatment for cisplatin-ineligible patients with muscle-invasive bladder cancer. Here we…”
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Delta-Opioid Receptor (δOR) Targeted Near-Infrared Fluorescent Agent for Imaging of Lung Cancer: Synthesis and Evaluation In Vitro and In Vivo by Cohen, Allison S, Patek, Renata, Enkemann, Steven A, Johnson, Joseph O, Chen, Tingan, Toloza, Eric, Vagner, Josef, Morse, David L

“…In the United States, lung cancer is the leading cause of cancer death and ranks second in the number of new cases annually among all types of cancers. Better…”
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Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma by Jardim-Perassi, Bruna V, Mu, Wei, Huang, Suning, Tomaszewski, Michal R, Poleszczuk, Jan, Abdalah, Mahmoud A, Budzevich, Mikalai M, Dominguez-Viqueira, William, Reed, Damon R, Bui, Marilyn M, Johnson, Joseph O, Martinez, Gary V, Gillies, Robert J

“…Hypoxic regions (habitats) within tumors are heterogeneously distributed and can be widely variant. Hypoxic habitats are generally pan-therapy resistant. For…”
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JAK2‐V617F‐mediated signalling is dependent on lipid rafts and statins inhibit JAK2‐V617F‐dependent cell growth by Griner, Lori N., McGraw, Kathy L., Johnson, Joseph O., List, Alan F., Reuther, Gary W.

“…Summary Aberrant JAK2 signalling plays an important role in the aetiology of myeloproliferative neoplasms (MPNs). JAK2 inhibitors, however, do not readily…”
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Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity by Zheng, Hong, Yu, Xiaoqing, Ibrahim, Mohammed L, Foresman, Dana, Xie, Mengyu, Johnson, Joseph O, Boyle, Theresa A, Ruffell, Brian, Perez, Bradford A, Antonia, Scott J, Ready, Neal, Saltos, Andreas N, Cantwell, Mark J, Beg, Amer A

“…Oncolytic virus therapies induce the direct killing of tumor cells and activation of conventional dendritic cells (cDC); however, cDC activation has not been…”
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Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells by Cui, Yongping, Borysova, Meghan K, Johnson, Joseph O, Guadagno, Thomas M

“…Activating B-Raf mutations arise in 60% to 70% of human melanomas and are thought to play a vital role in tumorigenesis, although how this occurs remains…”
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Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma by Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Johnson, Joseph O., Clark, Noel, Hajiran, Ali, Chang, Andrew, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Chahoud, Jad, Ferrall-Fairbanks, Meghan C., Spiess, Philippe E., Francis, Natasha, Fournier, Michelle, Dhillon, Jasreman, Park, Jong Y., Wang, Liang, Mulé, James J., Altrock, Philipp M., Manley, Brandon J.

“…Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a…”
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Diagnostic digital cytopathology: Are we ready yet? by House, Jarret C., Henderson-Jackson, Evita B., Johnson, Joseph O., Lloyd, Mark C., Dhillon, Jasreman, Ahmad, Nazeel, Hakam, Ardeshir, Khalbuss, Walid E., Leon, Marino E., Chhieng, David, Zhang, Xiaohui, Centeno, Barbara A., Bui, Marilyn M.

“…Background: The cytology literature relating to diagnostic accuracy using whole slide imaging is scarce. We studied the diagnostic concordance between glass…”
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MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion by JINGCHUNGAO, MCCONNELL, Matthew J, BIN YU, JIANNONG LI, BALKO, Justin M, BLACK, Esther P, JOHNSON, Joseph O, LLOYD, Mark C, ALTIOK, Soner, HAURA, Eric B

“…Signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in human cancer including lung cancer and has been implicated in…”
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Image Analysis of the Tumor Microenvironment by Lloyd, Mark C, Johnson, Joseph O, Kasprzak, Agnieszka, Bui, Marilyn M

“…In the field of pathology it is clear that molecular genomics and digital imaging represent two promising future directions, and both are as relevant to the…”
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Oncogenic B-RafV600E Induces Spindle Abnormalities, Supernumerary Centrosomes, and Aneuploidy in Human Melanocytic Cells by YONGPING CUI, BORYSOVA, Meghan K, JOHNSON, Joseph O, GUADAGNO, Thomas M

“…Abstract Activating B-Raf mutations arise in 60% to 70% of human melanomas and are thought to play a vital role in tumorigenesis, although how this occurs…”
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