Search Results - "JOHNSON, BENJAMIN M."

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds by Johnson, Benjamin M, Shu, Yue-Zhong, Zhuo, Xiaoliang, Meanwell, Nicholas A

“…The applications of fluorine in drug design continue to expand, facilitated by an improved understanding of its effects on physicochemical properties and the…”
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pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence by HANIEF SOFI, M, GUDI, Radhika, KARUMUTHIL-MELETHIL, Subha, PEREZ, Nicolas, JOHNSON, Benjamin M, VASU, Chenthamarakshan

“…Nonobese diabetic (NOD) mice spontaneously develop type 1 diabetes (T1D), progression of which is similar to that in humans, and therefore are widely used as a…”
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Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes by Gaudreau, Marie-Claude, Gudi, Radhika R., Li, Gongbo, Johnson, Benjamin M., Vasu, Chenthamarakshan

“…Progressive destruction of pancreatic islet β-cells by immune cells is a primary feature of type 1 diabetes (T1D) and therapies that can restore the functional…”
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Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor by You, Dan, Hillerman, Stephen, Locke, Gregory, Chaudhry, Charu, Stromko, Caitlyn, Murtaza, Anwar, Fan, Yi, Koenitzer, Jennifer, Chen, Yali, Briceno, Stephanie, Bhadra, Rajarshi, Duperret, Elizabeth, Gullo-Brown, Johnni, Gao, Chan, Zhao, Dandan, Feder, John, Curtin, Joshua, Degnan, Andrew P, Kumi, Godwin, Wittman, Mark, Johnson, Benjamin M, Parrish, Karen E, Gokulrangan, Giridharan, Morrison, John, Quigley, Michael, Hunt, John T, Salter-Cid, Luisa, Lees, Emma, Sanjuan, Miguel A, Liu, Jinqi

“…BackgroundHematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor…”
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Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery by Shu, Yue-Zhong, Johnson, Benjamin M., Yang, Tian J.

“…Metabolism-related liabilities continue to be a major cause of attrition for drug candidates in clinical development. Such problems may arise from the…”
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Pretreatment with Yeast-Derived Complex Dietary Polysaccharides Suppresses Gut Inflammation, Alters the Microbiota Composition, and Increases Immune Regulatory Short-Chain Fatty Acid Production in C57BL/6 Mice by Gudi, Radhika, Suber, Jada, Brown, Robert, Johnson, Benjamin M, Vasu, Chenthamarakshan

“…β-Glucans (BGs), a group of complex dietary polysaccharides (CDPs), are available as dietary supplements. However, the effects of orally administered highly…”
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Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice by Johnson, Benjamin M., Gaudreau, Marie-Claude, Gudi, Radhika, Brown, Robert, Gilkeson, Gary, Vasu, Chenthamarakshan

“…The risk of developing systemic lupus erythematosus (SLE) is about 9 times higher in women as compared to men. Our recent report, which used (SWRxNZB) F1…”
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Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response by Karumuthil-Melethil, Subha, Gudi, Radhika, Johnson, Benjamin M, Perez, Nicolas, Vasu, Chenthamarakshan

“…β-Glucans are naturally occurring polysaccharides in cereal grains, mushrooms, algae, or microbes, including bacteria, fungi, and yeast. Immune cells recognize…”
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Polysaccharide A-Dependent Opposing Effects of Mucosal and Systemic Exposures to Human Gut Commensal Bacteroides fragilis in Type 1 Diabetes by Sofi, M Hanief, Johnson, Benjamin M, Gudi, Radhika R, Jolly, Amy, Gaudreau, Marie-Claude, Vasu, Chenthamarakshan

“…(BF) is an integral component of the human colonic commensal microbiota. BF is also the most commonly isolated organism from clinical cases of intra-abdominal…”
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Abundance and nuclear antigen reactivity of intestinal and fecal Immunoglobulin A in lupus-prone mice at younger ages correlate with the onset of eventual systemic autoimmunity by Sun, Wei, Gudi, Radhika R., Johnson, Benjamin M., Vasu, Chenthamarakshan

“…Our recent studies, using (SWRxNZB)F1 (SNF1) mice, showed a potential contribution of the gut microbiota and pro-inflammatory immune responses of the gut…”
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Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes by Gudi, Radhika, Perez, Nicolas, Johnson, Benjamin M., Sofi, M. Hanief, Brown, Robert, Quan, Songhua, Karumuthil‐Melethil, Subha, Vasu, Chenthamarakshan

“…Summary The dietary supplement and prebiotic values of β‐glucan‐rich products have been widely recognized and dietary approaches for modulating autoimmunity…”
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Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus‐prone female SWR × NZB F1 (SNF1) mice by Gudi, Radhika R., Johnson, Benjamin M., Gaudreau, Marie‐Claude, Sun, Wei, Ball, Lauren, Vasu, Chenthamarakshan

“…The incidence of systemic lupus erythematosus (SLE) is about nine times higher in women than in men, and the underlying mechanisms that contribute to this…”
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Making a First Impression: The Characterisation of David and His Opening Words in 1 Samuel 17:25-31 by Benjamin J. M. Johnson

“…David is perhaps the most complex character in all of Scripture. He has been understood in many and various ways, from a backstabbing, ruthless warlord to a…”
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Identification of Novel Electrophilic Metabolites of Piper methysticum Forst. (Kava) by Johnson, Benjamin M, Qiu, Sheng-Xiang, Zhang, Shide, Zhang, Fagen, Burdette, Joanna E, Yu, Linning, Bolton, Judy L, van Breemen, Richard B

“…Dietary supplements containing Piper methysticum Forst. (kava) have been implicated in multiple cases of liver injury in humans, including 10 recently reviewed…”
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The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement by Donnelly, David J., Kim, Joonyoung, Tran, Tritin, Scola, Paul M., Tenney, Daniel, Pena, Adrienne, Petrone, Thomas, Zhang, Yunhui, Boy, Kenneth M., Poss, Michael A., Cole, Erin L., Soars, Matthew G., Johnson, Benjamin M., Cohen, Daniel, Batalla, Daniel, Chow, Patrick L., Shorts, Andrea Olga, Du, Shuyan, Meanwell, Nicholas A., Bonacorsi, Samuel J.

“…Purpose A same-day PET imaging agent capable of measuring PD-L1 status in tumors is an important tool for optimizing PD-1 and PD-L1 treatments. Herein we…”
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TLR2- and Dectin 1-associated innate immune response modulates T-cell response to pancreatic β-cell antigen and prevents type 1 diabetes by Karumuthil-Melethil, Subha, Sofi, M Hanief, Gudi, Radhika, Johnson, Benjamin M, Perez, Nicolas, Vasu, Chenthamarakshan

“…The progression of autoimmune diseases is dictated by deviations in the fine balance between proinflammatory versus regulatory responses, and pathogen…”
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6&6: A Transdisciplinary Approach to Art–Science Collaboration by CLARK, SARAH E., MAGRANE, ERIC, BAUMGARTNER, THOMAS, BENNETT, SCOTT E. K., BOGAN, MICHAEL, EDWARDS, TAYLOR, DIMMITT, MARK A., GREEN, HEATHER, HEDGCOCK, CHARLES, JOHNSON, BENJAMIN M., JOHNSON, MARIA R., VELO, KATHLEEN, WILDER, BENJAMIN T.

“…Despite an historical connection between the arts and sciences, in the past century, the two disciplines have been greatly siloed. However, there is a renewed…”
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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein‑2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain by Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

“…Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule…”
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In Vitro Formation of Quinoid Metabolites of the Dietary Supplement Cimicifuga racemosa (Black Cohosh) by Johnson, Benjamin M, van Breemen, Richard B

“…Botanical dietary supplements containing Cimicifuga racemosa (Actaea racemosa; black cohosh) are used commonly by women to assuage menopausal symptoms…”
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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain by Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

“…Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. BMS-986176/LX-9211 (4),…”
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