Search Results - "JOHNSON, Andrew D"

70-year legacy of the Framingham Heart Study by Andersson, Charlotte, Johnson, Andrew D., Benjamin, Emelia J., Levy, Daniel, Vasan, Ramachandran S.

“…The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961,…”
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GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database by Leslie, Richard, O'Donnell, Christopher J, Johnson, Andrew D

“…We created a deeply extracted and annotated database of genome-wide association studies (GWAS) results. GRASP v1.0 contains >6.2 million SNP-phenotype…”
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Primordial germ cells: the first cell lineage or the last cells standing? by Johnson, Andrew D, Alberio, Ramiro

“…Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the…”
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease by Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“…Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants…”
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Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease by Huan, Tianxiao, Joehanes, Roby, Song, Ci, Peng, Fen, Guo, Yichen, Mendelson, Michael, Yao, Chen, Liu, Chunyu, Ma, Jiantao, Richard, Melissa, Agha, Golareh, Guan, Weihua, Almli, Lynn M., Conneely, Karen N., Keefe, Joshua, Hwang, Shih-Jen, Johnson, Andrew D., Fornage, Myriam, Liang, Liming, Levy, Daniel

“…Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-associated variants from genome-wide association studies (GWAS) may…”
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An open access database of genome-wide association results by Johnson, Andrew D, O'Donnell, Christopher J

“…The number of genome-wide association studies (GWAS) is growing rapidly leading to the discovery and replication of many new disease loci. Combining results…”
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SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap by Johnson, Andrew D., Handsaker, Robert E., Pulit, Sara L., Nizzari, Marcia M., O'Donnell, Christopher J., de Bakker, Paul I. W.

“…The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible…”
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GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes by Eicher, John D, Landowski, Christa, Stackhouse, Brian, Sloan, Arielle, Chen, Wenjie, Jensen, Nicole, Lien, Ju-Ping, Leslie, Richard, Johnson, Andrew D

“…Here, we present an update on the Genome-Wide Repository of Associations between SNPs and Phenotypes (GRASP) database version 2.0…”
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Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors by Berbari, Nicolas F, Johnson, Andrew D, Lewis, Jacqueline S, Askwith, Candice C, Mykytyn, Kirk

“…Primary cilia are sensory organelles present on most mammalian cells. The functions of cilia are defined by the signaling proteins localized to the ciliary…”
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Genome-wide identification of microRNA expression quantitative trait loci by Huan, Tianxiao, Rong, Jian, Liu, Chunyu, Zhang, Xiaoling, Tanriverdi, Kahraman, Joehanes, Roby, Chen, Brian H., Murabito, Joanne M., Yao, Chen, Courchesne, Paul, Munson, Peter J., O’Donnell, Christopher J., Cox, Nancy, Johnson, Andrew D., Larson, Martin G., Levy, Daniel, Freedman, Jane E.

“…Identification of microRNA expression quantitative trait loci (miR-eQTL) can yield insights into regulatory mechanisms of microRNA transcription, and can help…”
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Identification of common genetic variants controlling transcript isoform variation in human whole blood by Zhang, Xiaoling, Joehanes, Roby, Chen, Brian H, Huan, Tianxiao, Ying, Saixia, Munson, Peter J, Johnson, Andrew D, Levy, Daniel, O'Donnell, Christopher J

“…Christopher O'Donnell and colleagues report a genome-wide screen for splicing quantitative trait loci (sQTLs) in 5,257 human blood samples. They identify cis…”
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NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl by Simpson, Luke A, Crowley, Darren, Forey, Teri, Acosta, Helena, Ferjentsik, Zoltan, Chatfield, Jodie, Payne, Alexander, Simpson, Benjamin S, Redwood, Catherine, Dixon, James E, Holmes, Nadine, Sang, Fei, Alberio, Ramiro, Loose, Matthew, Johnson, Andrew D

“…Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and germ cells are derived…”
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The genetics of platelet count and volume in humans by Eicher, John D., Lettre, Guillaume, Johnson, Andrew D.

“…The last decade has witnessed an explosion in the depth, variety, and amount of human genetic data that can be generated. This revolution in technical and…”
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Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases by Narayanan, Manikandan, Huynh, Jimmy L, Wang, Kai, Yang, Xia, Yoo, Seungyeul, McElwee, Joshua, Zhang, Bin, Zhang, Chunsheng, Lamb, John R, Xie, Tao, Suver, Christine, Molony, Cliona, Melquist, Stacey, Johnson, Andrew D, Fan, Guoping, Stone, David J, Schadt, Eric E, Casaccia, Patrizia, Emilsson, Valur, Zhu, Jun

“…Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in…”
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A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling by Rodriguez, Benjamin A.T., Bhan, Arunoday, Beswick, Andrew, Elwood, Peter C., Niiranen, Teemu J., Salomaa, Veikko, Trégouët, David-Alexandre, Morange, Pierre-Emmanuel, Civelek, Mete, Ben-Shlomo, Yoav, Schlaeger, Thorsten, Chen, Ming-Huei, Johnson, Andrew D.

“…Dual antiplatelet therapy reduces ischemic events in cardiovascular disease, but it increases bleeding risk. Thrombin receptors PAR1 and PAR4 are drug targets,…”
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A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors by Thibord, Florian, Chan, Melissa V., Chen, Ming-Huei, Johnson, Andrew D.

“…Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus…”
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Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G by Zhang, Ying, Wang, Danxin, Johnson, Andrew D., Papp, Audrey C., Sadée, Wolfgang

“…As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction. Genetic variants of OPRM1…”
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Cardiovascular correlates of platelet count and volume in the Framingham Heart Study by Sloan, Arielle, BS, Gona, Philimon, PhD, Johnson, Andrew D., PhD

“…Abstract Purpose Platelet count and volume are inexpensive, routinely assayed biomarkers associated with cardiovascular health, but specific relationships…”
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Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells by Wheldon, Lee M., Abakir, Abdulkadir, Ferjentsik, Zoltan, Dudnakova, Tatiana, Strohbuecker, Stephanie, Christie, Denise, Dai, Nan, Guan, Shengxi, Foster, Jeremy M., Corrêa, Ivan R., Loose, Matthew, Dixon, James E., Sottile, Virginie, Johnson, Andrew D., Ruzov, Alexey

“…5-Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene activity during differentiation. Tet dioxygenases oxidize 5mC to…”
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Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos by Chatfield, Jodie, O'Reilly, Marie-Anne, Bachvarova, Rosemary F, Ferjentsik, Zoltan, Redwood, Catherine, Walmsley, Maggie, Patient, Roger, Loose, Mathew, Johnson, Andrew D

“…A common feature of development in most vertebrate models is the early segregation of the germ line from the soma. For example, in Xenopus and zebrafish…”
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