Search Results - "JOHNS, FINNY"

Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses by Johnson, Benjamin S., Farkas, Daniela, El-Mergawy, Rabab, Adair, Jessica A., Elhance, Ajit, Eltobgy, Moemen, Coan, Francesca M., Chafin, Lexie, Joseph, Jessica A., Cornwell, Alex, Johns, Finny J., Rosas, Lorena, Rojas, Mauricio, Farkas, Laszlo, Bednash, Joseph S., Londino, James D., Ray, Prabir, Ray, Anuradha, Kagan, Valerian, Lee, Janet S., Chen, Bill B., Mallampalli, Rama K.

“…The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. We describe a mitochondrial…”
Get full text

Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS by Eltobgy, Moemen, Johns, Finny, Farkas, Daniela, Leuenberger, Laura, Cohen, Sarah P, Ho, Kevin, Karow, Sarah, Swoope, Gabrielle, Pannu, Sonal, Horowitz, Jeffrey C, Mallampalli, Rama K, Englert, Joshua A, Bednash, Joseph S

“…The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 and contributes to patient morbidity and mortality. ARDS is a…”
Get full text

The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome by Bednash, Joseph S., Johns, Finny, Patel, Niharika, Smail, Taylor R., Londino, James D., Mallampalli, Rama K.

“…The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a multimeric, cytoplasmic, protein complex that regulates maturation and secretion…”
Get full text

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection by Tsai, MuChun, Osman, Wissam, Adair, Jessica, ElMergawy, Rabab, Chafin, Lexie, Johns, Finny, Farkas, Daniela, Elhance, Ajit, Londino, James, Mallampalli, Rama K.

“…Influenza remains a major public health challenge, as the viral infection activates multiple biological networks linked to altered host innate immunity…”
Get full text

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2 by Bednash, Joseph S, Johns, Finny, Farkas, Daniela, Elhance, Ajit, Adair, Jessica, Cress, Kirstin, Yount, Jacob S, Kenney, Adam D, Londino, James D, Mallampalli, Rama K

“…Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a significant public health burden with limited…”
Get full text

Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling by BEDNASH, JOSEPH S., KAGAN, VALERIAN E., ENGLERT, JOSHUA A., FARKAS, DANIELA, TYURINA, YULIA Y., TYURIN, VLADIMIR A., SAMOVICH, SVETLANA N., FARKAS, LASZLO, ELHANCE, AJIT, JOHNS, FINNY, LEE, HYUNWOOK, CHENG, LIJUN, MAJUMDAR, ABHISHEK, JONES, DANIEL, MEJIA, OSCAR ROSAS, RUANE-FOSTER, MARISA, LONDINO, JAMES D., MALLAMPALLI, RAMA K., ROBINSON, RICHARD T.

“…The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute…”
Get full text