Search Results - "JOHANNING, Gary L"

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells by Zhou, Fuling, Li, Ming, Wei, Yongchang, Lin, Kevin, Lu, Yue, Shen, Jianjun, Johanning, Gary L, Wang-Johanning, Feng

“…Human endogenous retrovirus type K (HERV-K) Env protein was previously demonstrated to be overexpressed in human breast cancer (BC) cells and tissues. However,…”
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Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors by Wang-Johanning, Feng, Rycaj, Kiera, Plummer, Joshua B., Li, Ming, Yin, Bingnan, Frerich, Katherine, Garza, Jeremy G., Shen, Jianjun, Lin, Kevin, Yan, Peisha, Glynn, Sharon A., Dorsey, Tiffany H., Hunt, Kelly K., Ambs, Stefan, Johanning, Gary L.

“…Background The envelope (env) protein of the human endogenous retrovirus type K (HERV-K) family is commonly expressed on the surface of breast cancer cells. We…”
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Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients by Wang-Johanning, Feng, Radvanyi, Laszlo, Rycaj, Kiera, Plummer, Joshua B, Yan, Peisha, Sastry, K Jagannadha, Piyathilake, Chandrika J, Hunt, Kelly K, Johanning, Gary L

“…Recent evidence indicates that human cancer cells reactivate the expression of latent human endogenous retroviral (HERV) proteins. However, the extent to which…”
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Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer by Wang‐Johanning, Feng, Liu, Jinsong, Rycaj, Kiera, Huang, Miao, Tsai, Kate, Rosen, Daniel G., Chen, Dung‐Tsa, Lu, Danielle W., Barnhart, Kirstin F., Johanning, Gary L.

“…Individual classes of human endogenous retrovirus (HERV) genes and proteins are expressed in cancer, but expression of more than one type of HERV is rare. We…”
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A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate by Piyathilake, Chandrika J, Badiga, Suguna, Alvarez, Ronald D, Partridge, Edward E, Johanning, Gary L

“…Identification of associations between global DNA methylation and excess body weight (EBW) and related diseases and their modifying factors are an unmet…”
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The dataset for the assessment of the inflammatory potential of the overall diet consumed by women of childbearing age by Piyathilake, Chandrika J., Badiga, Suguna, Chappell, Ashley R., Johanning, Gary L., Jolly, Pauline E.

“…The data presented in this article is related to the research article titled “Racial differences in dietary choices and their relationship to inflammatory…”
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A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era by Badiga, Suguna, Johanning, Gary L, Macaluso, Maurizio, Azuero, Andres, Chambers, Michelle M, Siddiqui, Nuzhat R, Piyathilake, Chandrika J

“…Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher…”
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A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia by Piyathilake, Chandrika J., Ph.D, Macaluso, Maurizio, Dr.P.H, Alvarez, Ronald D., M.D, Chen, Min, M.D, Badiga, Suguna, M.Sc, Siddiqui, Nuzhat R., M.D, Edberg, Jeffrey C., Ph.D, Partridge, Edward E., M.D, Johanning, Gary L., Ph.D

“…Abstract Objective The objective of the study was to evaluate LINE-1 methylation as an intermediate biomarker for the effect of folate and vitamin B12 on the…”
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Quantitation of HERV-K env gene expression and splicing in human breast cancer by WANG-JOHANNING, Feng, FROST, Andra R, BIXI JIAN, EPP, Lidia, LU, Danielle W, JOHANNING, Gary L

“…Human endogenous retroviruses (HERVs) comprise up to 8% of the human genome. In previous studies, we demonstrated that type 1 HERV-K envelope (env) transcripts…”
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Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth by Li, Ming, Radvanyi, Laszlo, Yin, Bingnan, Rycaj, Kiera, Li, Jia, Chivukula, Raghavender, Lin, Kevin, Lu, Yue, Shen, JianJun, Chang, David Z, Li, Donghui, Johanning, Gary L, Wang-Johanning, Feng

“…We investigated the role of the human endogenous retrovirus type K (HERV-K) envelope ( ) gene in pancreatic cancer. shRNA was employed to knockdown (KD) the…”
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Quantitation of human papillomavirus 16 E6 and E7 DNA and RNA in residual material from ThinPrep Papanicolaou tests using real‐time polymerase chain reaction analysis by Wang‐Johanning, Feng, Lu, Danielle W., Wang, Yueying, Johnson, Martin R., Johanning, Gary L.

“…BACKGROUND The detection of specific human papillomavirus 16 (HPV‐16) E6 and E7 oncogene transcripts may be a sensitive indicator of the direct involvement of…”
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Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma by Wang‐Johanning, Feng, Frost, Andra R., Jian, Bixi, Azerou, Ricardo, Lu, Danielle W., Chen, Dung‐Tsa, Johanning, Gary L.

“…BACKGROUND The expression of human endogenous retrovirus (HERV) mRNA and proteins was associated recently with diseases that include human malignancies. The…”
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Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype by Johanning, Gary L., Malouf, Gabriel G., Zheng, Xiaofeng, Esteva, Francisco J., Weinstein, John N., Wang-Johanning, Feng, Su, Xiaoping

“…Human endogenous retroviruses (HERVs), which make up approximately 8% of the human genome, are overexpressed in some breast cancer cells and tissues but…”
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Cytotoxicity of human endogenous retrovirus K-specific T cells toward autologous ovarian cancer cells by Rycaj, Kiera, Plummer, Joshua B, Yin, Bingnan, Li, Ming, Garza, Jeremy, Radvanyi, Laszlo, Ramondetta, Lois M, Lin, Kevin, Johanning, Gary L, Tang, Dean G, Wang-Johanning, Feng

“…To determine whether HERV-K envelope (ENV) protein could function as a tumor-associated antigen and elicit specific T-cell responses against autologous ovarian…”
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Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early‐stage breast cancer by Wang‐Johanning, Feng, Li, Ming, Esteva, Francisco J., Hess, Kenneth R., Yin, Bingnan, Rycaj, Kiera, Plummer, Joshua B., Garza, Jeremy G., Ambs, Stefan, Johanning, Gary L.

“…A simple and accurate test to detect early‐stage breast cancer has not been developed. Previous studies indicate that the level of human endogenous retrovirus…”
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The role of human endogenous retroviruses in brain development and function by Mortelmans, Kristien, Wang-Johanning, Feng, Johanning, Gary L.

“…Endogenous retroviral sequences are spread throughout the genome of all humans, and make up about 8% of the genome. Despite their prevalence, the function of…”
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Racial differences in dietary choices and their relationship to inflammatory potential in childbearing age women at risk for exposure to COVID-19 by Piyathilake, Chandrika J, Badiga, Suguna, Chappell, Ashley R, Johanning, Gary L, Jolly, Pauline E

“…Since the ongoing coronavirus disease 2019 (COVID-19) pandemic is linked to chronic inflammation, people with initial lower inflammatory status could have…”
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Chimeric antigen receptor T cells targeting HERV-K inhibit breast cancer and its metastasis through downregulation of Ras by Zhou, Fuling, Krishnamurthy, Janani, Wei, Yongchang, Li, Ming, Hunt, Kelly, Johanning, Gary L, Cooper, Laurence JN, Wang-Johanning, Feng

“…We have previously reported that human endogenous retrovirus-K (HERV-K) envelope (env) protein is a tumor-associated antigen (TAA) for cancer vaccines, and…”
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Pattern to Knowledge: Deep Knowledge-Directed Machine Learning for Residue-Residue Interaction Prediction by Wong, Andrew K. C., Sze-To, Ho Yin, Johanning, Gary L.

“…Residue-residue close contact (R2R-C) data procured from three-dimensional protein-protein interaction (PPI) experiments is currently used for predicting…”
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Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status by Piyathilake, Chandrika J., M.P.H., Ph.D, Azrad, Maria, M. S, Macaluso, Maurizio, M.D., Dr. P.H, Johanning, Gary L., Ph.D, Cornwell, Phillip E., Ph.D, Partridge, Edward E., M.D, Heimburger, Douglas C., M.D

“…Abstract Objectives We previously reported that women polymorphic for the methylenetetrahydrofolate reductase (MTHFR) gene were less likely to have cervical…”
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