Search Results - "JOCHUM, Simon"

Development and Validation of the Elecsys Anti-SARS-CoV-2 Immunoassay as a Highly Specific Tool for Determining Past Exposure to SARS-CoV-2 by Muench, Peter, Jochum, Simon, Wenderoth, Verena, Ofenloch-Haehnle, Beatus, Hombach, Michael, Strobl, Matthias, Sadlowski, Henrik, Sachse, Christopher, Torriani, Giulia, Eckerle, Isabella, Riedel, Alexander

“…The Elecsys Anti-SARS-CoV-2 immunoassay (Roche Diagnostics) was developed to provide accurate, reliable detection of antibodies to severe acute respiratory…”
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The EBV immunoevasins vIL-10 and BNLF2a protect newly infected B cells from immune recognition and elimination by Jochum, Simon, Moosmann, Andreas, Lang, Stephan, Hammerschmidt, Wolfgang, Zeidler, Reinhard

“…Lifelong persistence of Epstein-Barr virus (EBV) in infected hosts is mainly owed to the virus' pronounced abilities to evade immune responses of its human…”
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Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 Trial by Jochum, Simon, Kirste, Imke, Hortsch, Sayuri, Grunert, Veit Peter, Legault, Holly, Eichenlaub, Udo, Kashlan, Basel, Pajon, Rolando

“…The ability to quantify an immune response after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential. This study…”
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Design and performance characteristics of the Elecsys anti-SARS-CoV-2 S assay by Taffertshofer, Karin, Walter, Mirko, Mackeben, Peter, Kraemer, Julia, Potapov, Sergej, Jochum, Simon

“…Automated, high throughput assays are required to quantify the immune response after infection with or vaccination against severe acute respiratory syndrome…”
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RNAs in Epstein–Barr virions control early steps of infection by Jochum, Simon, Ruiss, Romana, Moosmann, Andreas, Hammerschmidt, Wolfgang, Zeidler, Reinhard

“…Herpesviruses are dsDNA viruses, but their virions may additionally contain RNAs that can be transduced to recipient cells. The biological functions of herpes…”
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EBV-gp350 confers B-cell tropism to tailored exosomes and is a neo-antigen in normal and malignant B cells--a new option for the treatment of B-CLL by Ruiss, Romana, Jochum, Simon, Mocikat, Ralph, Hammerschmidt, Wolfgang, Zeidler, Reinhard

“…gp350, the major envelope protein of Epstein-Barr-Virus, confers B-cell tropism to the virus by interacting with the B lineage marker CD21. Here we utilize…”
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A Virus-Like Particle-Based Epstein-Barr Virus Vaccine by RUISS, Romana, JOCHUM, Simon, WANNER, Gerhard, REISBACH, Gilbert, HAMMERSCHMIDT, Wolfgang, ZEIDLER, Reinhard

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients by Rubio-Acero, Raquel, Castelletti, Noemi, Fingerle, Volker, Olbrich, Laura, Bakuli, Abhishek, Wölfel, Roman, Girl, Philipp, Müller, Katharina, Jochum, Simon, Strobl, Matthias, Hoelscher, Michael, Wieser, Andreas

“…Background Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and…”
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Monoclonal Antibodies as SARS-CoV-2 Serology Standards: Experimental Validation and Broader Implications for Correlates of Protection by Wang, Lili, Patrone, Paul N., Kearsley, Anthony J., Izac, Jerilyn R., Gaigalas, Adolfas K., Prostko, John C., Kwon, Hyung Joon, Tang, Weichun, Kosikova, Martina, Xie, Hang, Tian, Linhua, Elsheikh, Elzafir B., Kwee, Edward J., Kemp, Troy, Jochum, Simon, Thornburg, Natalie, McDonald, L. Clifford, Gundlapalli, Adi V., Lin-Gibson, Sheng

“…COVID-19 has highlighted challenges in the measurement quality and comparability of serological binding and neutralization assays. Due to many different assay…”
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Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD by Kennedy, Nicholas A, Lin, Simeng, Goodhand, James R, Chanchlani, Neil, Hamilton, Benjamin, Bewshea, Claire, Nice, Rachel, Chee, Desmond, Cummings, Jr Fraser, Fraser, Aileen, Irving, Peter M, Kamperidis, Nikolaos, Kok, Klaartje B, Lamb, Christopher Andrew, Macdonald, Jonathan, Mehta, Shameer, Pollok, Richard Cg, Raine, Tim, Smith, Philip J, Verma, Ajay Mark, Jochum, Simon, McDonald, Timothy J, Sebastian, Shaji, Lees, Charlie W, Powell, Nick, Ahmad, Tariq

“…Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether…”
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Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC by Battke, Christina, Ruiss, Romana, Welsch, Ulrich, Wimberger, Pauline, Lang, Stephan, Jochum, Simon, Zeidler, Reinhard

“…In order to grow within an immunocompetent host, tumour cells have evolved various strategies to cope with the host’s immune system. These strategies include…”
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Analytical performance evaluation of the Elecsys Epstein-Barr virus immunoassay panel by Schulte-Spechtel, Ulrike, Berth, Mario, Lauseker-Hao, Yi, Meyer-Schlinkmann, Kristin, Bohnert, Martin, Jochum, Simon, Schuhmann, Kerstin

“…•We evaluated the analytical performance of the Elecsys® EBV immunoassay panel.•The Elecsys EBV panel comprises tests for EBV IgM, EBV VCA IgG, and EBV EBNA…”
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Quantifying the Vaccine-Induced Humoral Immune Response to Spike-Receptor Binding Domain as a Surrogate for Neutralization Testing Following mRNA-1273 (Spikevax) Vaccination Against COVID-19 by Kirste, Imke, Hortsch, Sayuri, Grunert, Veit Peter, Legault, Holly, Maglinao, Maha, Eichenlaub, Udo, Kashlan, Basel, Pajon, Rolando, Jochum, Simon

“…Introduction There is a need for automated, high-throughput assays to quantify immune response after SARS-CoV-2 vaccination. This study assessed the combined…”
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RNAs in Epstein-Barr virions control early steps of infection by Jochum, Simon, Ruiss, Romana, Moosmann, Andreas, Hammerschmidt, Wolfgang, Zeidler, Reinhard

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients by Rubio-Acero, Raquel, Castelletti, Noemi, Fingerle, Volker, Olbrich, Laura, Bakuli, Abhishek, Wölfel, Roman, Girl, Philipp, Müller, Katharina, Jochum, Simon, Strobl, Matthias, Hoelscher, Michael, Wieser, Andreas

“…Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and correlation of two…”
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