Search Results - "JOAO SARAIVA, M"

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants by Quintas, Alexandre, Vaz, Daniela C., Cardoso, Isabel, Saraiva, Maria João M., Brito, Rui M.M.

“…Amyloid fibril formation and deposition is a common feature of a wide range of fatal diseases including spongiform encephalopathies, Alzheimer's disease, and…”
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Sulfite and base for the treatment of familial amyloidotic polyneuropathy: two additive approaches to stabilize the conformation of human amyloidogenic transthyretin by ALTLAND, Klaus, WINTER, Pia, SARAIVA, Maria Joao M, SUHR, Ole

“…Recently, we presented evidence that sulfite protects transthyretin (TTR) from normal human individuals and heterozygotes with amyloidogenic TTR mutations…”
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Interaction of the Receptor for Advanced Glycation End Products (RAGE) with Transthyretin Triggers Nuclear Transcription Factor kB (NF-kB) Activation by MENDES SOUSA, M, SHI DU YAN, STERN, D, JOAO SARAIVA, M

“…Mutated transthyretin (TTR) fibrils are associated with the pathology of familial amyloidotic polyneuropathy (FAP), in which extracellular amyloid deposits…”
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A new mutation causing familial amyloidotic polyneuropathy by Skare, J C, Saraiva, M J, Alves, I L, Skare, I B, Milunsky, A, Cohen, A S, Skinner, M

“…The DNA from an individual with familial amyloidotic polyneuropathy was examined. It did not possess any of the mutations which have previously been associated…”
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Designing transthyretin mutants affecting tetrameric structure: implications in amyloidogenicity by REDONDO, Clara, DAMAS, Ana M., SARAIVA, Maria João M.

“…The molecular mechanisms that convert soluble transthyretin (TTR) tetramers into insoluble amyloid fibrils are still unknown; dissociation of the TTR tetramer…”
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The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution by Quintas, Alexandre, Saraiva, Maria João M., Brito, Rui M.M.

“…In amyloidosis, normally innocuous soluble proteins polymerize to form insoluble fibrils. Amyloid fibril formation and deposition have been associated with a…”
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Genetic anticipation in Portuguese kindreds with familial amyloidotic polyneuropathy is unlikely to be caused by triplet repeat expansions by SOARES, M, BUXBAUM, J, SIRUGO, G, COELHO, T, SOUSA, A, KASTNER, D, JOAO SARAIVA, M

“…Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant type of amyloidosis resulting from the deposition of transthyretin (ATTR) variants in…”
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Screening and biochemical characterization of transthyretin variants in the Portuguese population by Alves, Isabel L., Altland, Klaus, Almeida, Maria Rosário, Winter, Pia, Saraiva, Maria João M.

“…The study of pathogenic and nonpathogenic transthyretin (TTR) variants is very important for the understanding of such TTR‐related diseases as hereditary…”
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The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis by Quintas, A, Saraiva, M J, Brito, R M

“…In amyloidosis, normally innocuous soluble proteins polymerize to form insoluble fibrils. Amyloid fibril formation and deposition have been associated with a…”
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Kinetic Assay for High-Throughput Screening of In Vitro Transthyretin Amyloid Fibrillogenesis Inhibitors by Dolado, Ignacio, Nieto, Joan, Saraiva, Maria João M, Arsequell, Gemma, Valencia, Gregori, Planas, Antoni

“…Stabilization of tetrameric transthyretin (TTR) by binding of small ligands is a current strategy aimed at inhibiting amyloid fibrillogenesis in…”
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Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP) by Furuya, Hirokazu, Saraiva, Maria Joao Mascarenhas, Gawinowicz, Mary Ann, Alves, Isabel Longo, Costa, Pedro P, Sasaki, Hiroyuki, Goto, Ikuo, Sakaki, Yoshiyuki

“…Transthyretin (TTR) is a plasma protein interacting with thyroxine T4 and retinol binding protein (RBP). Several variants of TTR with single amino acid…”
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Thyroxine binding in a TTR Met 119 kindred by Alves, I L, Divino, C M, Schussler, G C, Altland, K, Almeida, M R, Palha, J A, Coelho, T, Costa, P P, Saraiva, M J

“…Recently, a transthyretin variant, TTR Met 119, in which methionine substitutes for threonine 119, a component of the protein's iodothyronine binding site, was…”
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Designing transthyretin mutants affecting tetrameric structure: implications in amyloidogenicity by Redondo, C, Damas, A M, Saraiva, M J

“…The molecular mechanisms that convert soluble transthyretin (TTR) tetramers into insoluble amyloid fibrils are still unknown; dissociation of the TTR tetramer…”
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Search for intermediate structures in transthyretin fibrillogenesis: soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils by Redondo, Clara, Damas, Ana Margarida, Olofsson, Anders, Lundgren, Erik, Saraiva, Maria João M.

“…Familial Amyloidotic Polyneuropathy (FAP) is caused by the assembly of TTR into an insoluble β-sheet. The TTR tetramer is thought to dissociate into monomeric…”
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Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin by Shnyrov, Valery L., Villar, Enrique, Zhadan, Galina G., Sanchez-Ruiz, Jose M., Quintas, Alexandre, Saraiva, Maria João M., Brito, Rui M.M.

“…Familial amyloidotic polyneuropathy (FAP) is an autosomal dominant hereditary type of amyloidosis involving amino acid substitutions in transthyretin (TTR)…”
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W02.117 The absence of transthyretin influences mouse fat and glucose metabolism by Marques, F., Sousa, J.Carlos, de Oliveira, H.Franco Coutinho, Sousa, N., João Saraiva, M., Almeida Palha, J.

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Presence of a plasma transthyretin (prealbumin) variant in familial amyloidotic polyneuropathy in a kindred of Greek origin by Saraiva, M J, Sherman, W, Goodman, D S

“…Human plasma transthyretin (TTR, a protein formerly called prealbumin) is known to be associated with familial amyloidotic polyneuropathy (FAP) of autosomal…”
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Prenatal diagnosis of familial amyloidotic polyneuropathy : evidence for an early expression of the associated transthyretin methionine 30 by ALMEIDA, M. R, ALVES, I. L, SAKAKI, Y, COSTA, P. P, SARAIVA, M. J

“…Transthyretin methionine 30 (TTR Met 30), which is associated with familial amyloidotic polyneuropathy, originates in a single base substitution (A for G) in…”
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