Search Results - "JOACHIMIAK, Andrzej"

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors by Osipiuk, Jerzy, Azizi, Saara-Anne, Dvorkin, Steve, Endres, Michael, Jedrzejczak, Robert, Jones, Krysten A., Kang, Soowon, Kathayat, Rahul S., Kim, Youngchang, Lisnyak, Vladislav G., Maki, Samantha L., Nicolaescu, Vlad, Taylor, Cooper A., Tesar, Christine, Zhang, Yu-An, Zhou, Zhiyao, Randall, Glenn, Michalska, Karolina, Snyder, Scott A., Dickinson, Bryan C., Joachimiak, Andrzej

“…The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2…”
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Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2 by Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I., Wilamowski, Mateusz, Endres, Michael, Godzik, Adam, Michalska, Karolina, Joachimiak, Andrzej

“…Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent…”
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The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1 by Cao, Yangrong, Liang, Yan, Tanaka, Kiwamu, Nguyen, Cuong T, Jedrzejczak, Robert P, Joachimiak, Andrzej, Stacey, Gary

“…Chitin is a fungal microbe-associated molecular pattern recognized in Arabidopsis by a lysin motif receptor kinase (LYK), AtCERK1. Previous research suggested…”
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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2 by Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej

“…SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in…”
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Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes by Michalska, Karolina, Kim, Youngchang, Jedrzejczak, Robert, Maltseva, Natalia I, Stols, Lucy, Endres, Michael, Joachimiak, Andrzej

“…Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One…”
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Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets by Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.

“…Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used…”
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Physiological aspects of sex differences and Haldane’s rule in Rumex hastatulus by Joachimiak, Andrzej J., Libik-Konieczny, Marta, Wójtowicz, Tomasz, Sliwinska, Elwira, Grabowska-Joachimiak, Aleksandra

“…Haldane’s rule (HR, impairment of fertility and/or viability of interracial hybrids) seems to be one of few generalizations in evolutionary biology. The…”
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Bifidobacterium longum subsp. infantis ATCC 15697 α-Fucosidases Are Active on Fucosylated Human Milk Oligosaccharides by Sela, David A, Garrido, Daniel, Lerno, Larry, Wu, Shuai, Tan, Kemin, Eom, Hyun-Ju, Joachimiak, Andrzej, Lebrilla, Carlito B, Mills, David A

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase by Wellington, Samantha, Nag, Partha P, Michalska, Karolina, Johnston, Stephen E, Jedrzejczak, Robert P, Kaushik, Virendar K, Clatworthy, Anne E, Siddiqi, Noman, McCarren, Patrick, Bajrami, Besnik, Maltseva, Natalia I, Combs, Senya, Fisher, Stewart L, Joachimiak, Andrzej, Schreiber, Stuart L, Hung, Deborah T

“…High-throughput screening identifies an inhibitor of the interaction between α- and β-subunits of the Mycobacterium tuberculosis (Mtb) tryptophan synthase,…”
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Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin by Wydorski, Pawel M., Osipiuk, Jerzy, Lanham, Benjamin T., Tesar, Christine, Endres, Michael, Engle, Elizabeth, Jedrzejczak, Robert, Mullapudi, Vishruth, Michalska, Karolina, Fidelis, Krzysztof, Fushman, David, Joachimiak, Andrzej, Joachimiak, Lukasz A.

“…The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and…”
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Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 by Sanders, Brian C., Pokhrel, Suman, Labbe, Audrey D., Mathews, Irimpan I., Cooper, Connor J., Davidson, Russell B., Phillips, Gwyndalyn, Weiss, Kevin L., Zhang, Qiu, O’Neill, Hugh, Kaur, Manat, Schmidt, Jurgen G., Reichard, Walter, Surendranathan, Surekha, Parvathareddy, Jyothi, Phillips, Lexi, Rainville, Christopher, Sterner, David E., Kumaran, Desigan, Andi, Babak, Babnigg, Gyorgy, Moriarty, Nigel W., Adams, Paul D., Joachimiak, Andrzej, Hurst, Brett L., Kumar, Suresh, Butt, Tauseef R., Jonsson, Colleen B., Ferrins, Lori, Wakatsuki, Soichi, Galanie, Stephanie, Head, Martha S., Parks, Jerry M.

“…Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2…”
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How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator by Kim, Youngchang, Joachimiak, Grazyna, Bigelow, Lance, Babnigg, Gyorgy, Joachimiak, Andrzej

“…Bacterial catabolism of aromatic compounds from various sources including phenylpropanoids and flavonoids that are abundant in soil plays an important role in…”
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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase by Michalska, Karolina, Chang, Changsoo, Maltseva, Natalia I., Jedrzejczak, Robert, Robertson, Gregory T., Gusovsky, Fabian, McCarren, Patrick, Schreiber, Stuart L., Nag, Partha P., Joachimiak, Andrzej

“…Global dispersion of multidrug resistant bacteria is very common and evolution of antibiotic‐resistance is occurring at an alarming rate, presenting a…”
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike by Guthmiller, Jenna J, Stovicek, Olivia, Wang, Jiaolong, Changrob, Siriruk, Li, Lei, Halfmann, Peter, Zheng, Nai-Ying, Utset, Henry, Stamper, Christopher T, Dugan, Haley L, Miller, William D, Huang, Min, Dai, Ya-Nan, Nelson, Christopher A, Hall, Paige D, Jansen, Maud, Shanmugarajah, Kumaran, Donington, Jessica S, Krammer, Florian, Fremont, Daved H, Joachimiak, Andrzej, Kawaoka, Yoshihiro, Tesic, Vera, Madariaga, Maria Lucia, Wilson, Patrick C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted…”
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Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography by Kneller, Daniel W., Phillips, Gwyndalyn, O’Neill, Hugh M., Jedrzejczak, Robert, Stols, Lucy, Langan, Paul, Joachimiak, Andrzej, Coates, Leighton, Kovalevsky, Andrey

“…The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic health crisis. An attractive target for antiviral inhibitors is the main…”
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A family of LIC vectors for high-throughput cloning and purification of proteins by Eschenfeldt, William H, Lucy, Stols, Millard, Cynthia Sanville, Joachimiak, Andrzej, Mark, I Donnelly

“…Fifteen related ligation-independent cloning vectors were constructed for high-throughput cloning and purification of proteins. The vectors encode a TEV…”
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Testing the translocation hypothesis and Haldane’s rule in Rumex hastatulus by Kasjaniuk, Magdalena, Grabowska-Joachimiak, Aleksandra, Joachimiak, Andrzej J.

“…The translocation hypothesis regarding the origin of the XX/XY1Y2 sex chromosome system was tested with reference to the F1 hybrids between two chromosomal…”
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Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site by Cao, Nan, Tan, Kemin, Annamalai, Thirunavukkarasu, Joachimiak, Andrzej, Tse-Dinh, Yuk-Ching

“…Abstract We have obtained new crystal structures of Mycobacterium tuberculosis topoisomerase I, including structures with ssDNA substrate bound to the active…”
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Promising approaches for the assembly of the catalytically active, recombinant Desulfomicrobium baculatum hydrogenase with substitutions at the active site by Witkowska, Malgorzata, Jedrzejczak, Robert P, Joachimiak, Andrzej, Cavdar, Onur, Malankowska, Anna, Skowron, Piotr M, Zylicz-Stachula, Agnieszka

“…Hydrogenases (H2ases) are metalloenzymes capable of the reversible conversion of protons and electrons to molecular hydrogen. Exploiting the unique enzymatic…”
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Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins by Gucinski, Grant C., Michalska, Karolina, Garza-Sánchez, Fernando, Eschenfeldt, William H., Stols, Lucy, Nguyen, Josephine Y., Goulding, Celia W., Joachimiak, Andrzej, Hayes, Christopher S.

“…Contact-dependent growth inhibition (CDI) is a form of interbacterial competition mediated by CdiB-CdiA two-partner secretion systems. CdiA effector proteins…”
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