Search Results - "JINMIN GAO"

The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis by Liu, Libo, Li, Jiaxiang, Ke, Yueshuang, Zeng, Xianlu, Gao, Jinmin, Ba, Xueqing, Wang, Ruoxi

“…Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's…”
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Control of Chromatin Organization and Chromosome Behavior during the Cell Cycle through Phase Separation by Li, Jiaxiang, Gao, Jinmin, Wang, Ruoxi

“…Phase-separated condensates participate in various biological activities. Liquid-liquid phase separation (LLPS) can be driven by collective interactions…”
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Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop by Nadarajan, Saravanapriah, Lambert, Talley J, Altendorfer, Elisabeth, Gao, Jinmin, Blower, Michael D, Waters, Jennifer C, Colaiácovo, Monica P

“…The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the…”
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CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation by Yang, Yunfan, Liu, Min, Li, Dengwen, Ran, Jie, Gao, Jinmin, Suo, Shaojun, Sun, Shao-Cong, Zhou, Jun

“…Oriented cell division is critical for cell fate specification, tissue organization, and tissue homeostasis, and relies on proper orientation of the mitotic…”
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Multivalent weak interactions between assembly units drive synaptonemal complex formation by Zhang, Zhenguo, Xie, Songbo, Wang, Ruoxi, Guo, Shuqun, Zhao, Qiuchen, Nie, Hui, Liu, Yuanyuan, Zhang, Fengguo, Chen, Miao, Liu, Libo, Meng, Xiaoqian, Liu, Min, Zhao, Li, Colaiácovo, Monica P, Zhou, Jun, Gao, Jinmin

“…The synaptonemal complex (SC) is an ordered but highly dynamic structure assembled between homologous chromosomes to control interhomologous crossover…”
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ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis by Shao, Qiqi, Zhang, Yanan, Liu, Yanlei, Shang, Yongliang, Li, Si, Liu, Lin, Wang, Guoqiang, Zhou, Xu, Wang, Ping, Gao, Jinmin, Zhou, Jun, Zhang, Liangran, Wang, Shunxin

“…Meiotic crossovers are required for the faithful segregation of homologous chromosomes and to promote genetic diversity. However, it is unclear how crossover…”
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CYLD regulates angiogenesis by mediating vascular endothelial cell migration by Gao, Jinmin, Sun, Lei, Huo, Lihong, Liu, Min, Li, Dengwen, Zhou, Jun

“…Cylindromatosis (CYLD) is a deubiquitinase that was initially identified as a tumor suppressor and has recently been implicated in diverse normal physiologic…”
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SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans by Liu, Yuanyuan, Zhao, Qiuchen, Nie, Hui, Zhang, Fengguo, Fu, Tingting, Zhang, Zhenguo, Qi, Feifei, Wang, Ruoxi, Zhou, Jun, Gao, Jinmin

“…Abstract Meiosis produces the haploid gametes required by all sexually reproducing organisms, occurring in specific temperature ranges in different organisms…”
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Cofactor-independent C-C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis by Gao, Jinmin, Li, Liyuan, Shen, Shijie, Ai, Guomin, Wang, Bin, Guo, Fang, Yang, Tongjian, Han, Hui, Xu, Zhengren, Pan, Guohui, Fan, Keqiang

“…Biosynthesis of atypical angucyclines involves unique oxidative B-ring cleavage and rearrangement reactions, which are catalyzed by AlpJ-family oxygenases,…”
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N-terminal acetylation promotes synaptonemal complex assembly in C. elegans by Gao, Jinmin, Barroso, Consuelo, Zhang, Pan, Kim, Hyun-Min, Li, Shangtong, Labrador, Leticia, Lightfoot, James, Gerashchenko, Maxim V, Labunskyy, Vyacheslav M, Dong, Meng-Qiu, Martinez-Perez, Enrique, Colaiácovo, Monica P

“…N-terminal acetylation of the first two amino acids on proteins is a prevalent cotranslational modification. Despite its abundance, the biological processes…”
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The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline by Wang, Simon Yuan, Mao, Hui, Shibuya, Hiroki, Uzawa, Satoru, O'Brown, Zach Klapholz, Wesenberg, Sage, Shin, Nara, Saito, Takamune T, Gao, Jinmin, Meyer, Barbara J, Colaiácovo, Monica P, Greer, Eric Lieberman

“…The biological roles of nucleic acid methylation, other than at the C5-position of cytosines in CpG dinucleotides, are still not well understood. Here, we…”
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The Tumor Suppressor CYLD Regulates Microtubule Dynamics and Plays a Role in Cell Migration by Gao, Jinmin, Huo, Lihong, Sun, Xiaoou, Liu, Min, Li, Dengwen, Dong, Jin-Tang, Zhou, Jun

“…The familial cylindromatosis tumor suppressor CYLD is known to contain three cytoskeleton-associated protein glycine-rich (CAP-Gly) domains, which exist in a…”
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NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis by Gao, Jinmin, Kim, Hyun-Min, Elia, Andrew E, Elledge, Stephen J, Colaiácovo, Monica P

“…The formation of DNA double-strand breaks (DSBs) must take place during meiosis to ensure the formation of crossovers, which are required for accurate…”
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EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A by Sun, Lei, Gao, Jinmin, Dong, Xin, Liu, Min, Li, Dengwen, Shi, Xingjuan, Dong, Jin-Tang, Lu, Xianyu, Liu, Chunyong, Zhou, Jun

“…EB1 (end-binding protein 1) is a key player in the regulation of microtubule dynamics. In concert with its binding partners, adenomatous polyposis coli and…”
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The B-box module of CYLD is responsible for its intermolecular interaction and cytoplasmic localization by Xie, Songbo, Chen, Miao, Gao, Siqi, Zhong, Tao, Zhou, Peng, Li, Dengwen, Zhou, Jun, Gao, Jinmin, Liu, Min

“…The tumor suppressor protein cylindromatosis (CYLD), as a microtubule-associated deubiquitinase, plays a pivotal role in a wide range of cellular activities,…”
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CYLD regulates RhoA activity by modulating LARG ubiquitination by Yang, Yunfan, Sun, Lei, Tala, Gao, Jinmin, Li, Dengwen, Zhou, Jun, Liu, Min

“…Rho family guanosine triphosphatases (GTPases), such as RhoA, Cdc42, and Rac1, play a fundamental role in various cellular processes. The activation of Rho…”
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Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B by Sun, Lei, Gao, Jinmin, Huo, Lihong, Sun, Xiaoou, Shi, Xingjuan, Liu, Min, Li, Dengwen, Zhang, Chuanmao, Zhou, Jun

“…The familial cylindromatosis tumour suppressor CYLD contains three cytoskeleton-associated protein glycine-rich (CAP-Gly) domains and a deubiquitinase domain…”
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A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration by KARNA, Prasanthi, RIDA, Padmashree C. G, CHAKRA TURAGA, Ravi, JINMIN GAO, GUPTA, Meenakshi, FRITZ, Andreas, WERNER, Erica, YATES, Clayton, JUN ZHOU, ANEJA, Ritu

“…Endothelial tubular morphogenesis relies on an exquisite interplay of microtubule dynamics and actin remodeling to propel directed cell migration. Recently,…”
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Multidrug Resistance-Associated Protein-Overexpressing Teniposide-Resistant Human Lymphomas Undergo Apoptosis by a Tubulin-Binding Agent by ANEJA, Ritu, MIN LIU, YATES, Clayton, JINMIN GAO, XIN DONG, BINFEI ZHOU, VANGAPANDU, Surya N, JUN ZHOU, JOSHI, Harish C

“…Several DNA- and microtubule-binding agents are used to manage hematologic malignancies in the clinic. However, drug resistance has been a challenge, perhaps…”
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Reproductive aging: biological pathways and potential interventive strategies by Liu, Yuanyuan, Gao, Jinmin

“…Reproductive aging is a natural process conserved across species and is well-known in females. It shows age-related follicle depletion and reduction of oocyte…”
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