Search Results - "JINGLU AI"

Mast Cell Promotes the Development of Intracranial Aneurysm Rupture by Furukawa, Hajime, Wada, Kosuke, Tada, Yoshiteru, Kuwabara, Atsushi, Sato, Hiroki, Ai, Jinglu, Lawton, Michael T., Hashimoto, Tomoki

“…BACKGROUND AND PURPOSE:Inflammation has emerged as a key component of the pathophysiology of intracranial aneurysms. Mast cells have been detected in human…”
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Gene expression profiling of brain endothelial cells after experimental subarachnoid haemorrhage by Tso, Michael K., Turgeon, Paul, Bosche, Bert, Lee, Charles K., Nie, Tian, D’Abbondanza, Josephine, Ai, Jinglu, Marsden, Philip A., Macdonald, R. Loch

“…Subarachnoid haemorrhage (SAH) is a type of hemorrhagic stroke that is associated with high morbidity and mortality. New effective treatments are needed to…”
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Genetic Elimination of eNOS Reduces Secondary Complications of Experimental Subarachnoid Hemorrhage by Sabri, Mohammed, Ai, Jinglu, Lass, Elliot, D'abbondanza, Josephine, Macdonald, R Loch

“…Delayed complications of subarachnoid hemorrhage (SAH) such as angiographic vasospasm, cortical spreading ischemia, microcirculatory dysfunction, and…”
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Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage by Sabri, Mohammed, Ai, Jinglu, Knight, Britta, Tariq, Asma, Jeon, Hyojin, Shang, Xueyuan, Marsden, Philip Anthony, Macdonald, Robert Loch

“…We studied whether endothelial nitric oxide synthase (eNOS) is upregulated and uncoupled in large cerebral arteries after subarachnoid hemorrhage (SAH) and…”
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Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage by Jeon, Hyojin, Ai, Jinglu, Sabri, Mohamed, Tariq, Asma, Shang, Xueyuan, Chen, Gang, Macdonald, R Loch

“…About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurobehavioral dysfunction. Animal studies…”
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Dissociation of Vasospasm and Secondary Effects of Experimental Subarachnoid Hemorrhage by Clazosentan by SABRI, Mohammed, JINGLU AI, LOCH MACDONALD, R

“…Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used…”
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Anterior circulation mouse model of subarachnoid hemorrhage by Sabri, Mohammed, Jeon, Hyojin, Ai, Jinglu, Tariq, Asma, Shang, Xueyuan, Chen, Gang, Macdonald, R. Loch

“…Abstract A model of subarachnoid hemorrhage (SAH) first described in rats where blood is injected into the prechiasmatic cistern was adapted to mice. The…”
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Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: A possible cause for poor prognosis by Sabri, Mohammed, Kawashima, Ayako, Ai, Jinglu, Macdonald, R. Loch

“…Abstract Clinical evidence suggests that factors other than cerebral vasospasm, such as delayed neuronal and astrocytic cell death, may play a role in the poor…”
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Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage by Sabri, Mohammed, Ai, Jinglu, Marsden, Philip A, Macdonald, R Loch

“…Reduced endothelial nitric oxide synthase (eNOS) function has been linked to secondary complications of subarachnoid hemorrhage (SAH). We previously found that…”
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In vivo imaging of lymphatic drainage of cerebrospinal fluid in mouse by Mathieu, Emily, Gupta, Neeru, Macdonald, R Loch, Ai, Jinglu, Yücel, Yeni H

“…Mouse models are commonly used to study central nervous system disorders, in which cerebrospinal fluid (CSF) drainage may be disturbed. However, mouse CSF…”
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Platelet-mediated changes to neuronal glutamate receptor expression at sites of microthrombosis following experimental subarachnoid hemorrhage by Bell, Joshua D, Thomas, Theresa Currier, Lass, Elliot, Ai, Jinglu, Wan, Hoyee, Lifshitz, Jonathan, Baker, Andrew J, Macdonald, R Loch

“…Glutamate is important in the pathogenesis of brain damage after cerebral ischemia and traumatic brain injury. Notably, brain extracellular and cerebrospinal…”
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Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis by Zoerle, Tommaso, Ilodigwe, Don C, Wan, Hoyee, Lakovic, Katarina, Sabri, Mohammed, Ai, Jinglu, Macdonald, R Loch

“…Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim…”
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Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage by Chen, Gang, Zhang, Shiming, Shi, Jixin, Ai, Jinglu, Hang, Chunhua

“…Previous studies have shown that recombinant human erythropoietin (rhEPO) can attenuate the degree of cerebral vasospasm following experimental subarachnoid…”
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Molecular Alterations in the Hippocampus after Experimental Subarachnoid Hemorrhage by Han, Sang Myung, Wan, Hoyee, Kudo, Gen, Foltz, Warren D, Vines, Douglass C, Green, David E, Zoerle, Tommaso, Tariq, Asma, Brathwaite, Shakira, D'Abbondanza, Josephine, Ai, Jinglu, Macdonald, R Loch

“…Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or may not be associated with detectable brain…”
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Mechanisms of microthrombosis and microcirculatory constriction after experimental subarachnoid hemorrhage by Sabri, Mohammed, Ai, Jinglu, Lakovic, Katarina, Macdonald, R Loch

“…Microcirculatory dysfunction may contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). This study investigated structural changes in…”
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Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells by Bell, Joshua D., Ai, Jinglu, Chen, Yonghong, Baker, Andrew J.

“…Mild brain trauma results in a wide range of neurological symptoms that are not easily explained by the primary pathology. Purkinje neurons of the cerebellum…”
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Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma by Hare, Gregory M. T, Mazer, C. David, Hutchison, James S, McLaren, Anya T, Liu, Elaine, Rassouli, Alipasha, Ai, Jinglu, Shaye, Rachel E, Lockwood, Julia A, Hawkins, Cynthia E, Sikich, Nancy, To, Kevin, Baker, Andrew J

“…1 Department of Anesthesia, Cara Phelan Centre for Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge Institute, University of Toronto, St…”
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Voltage-gated K channel dysfunction in myocytes from a dog model of subarachnoid hemorrhage by Jahromi, Babak S, Aihara, Yasuo, Ai, Jinglu, Zhang, Zhen-Du, Nikitina, Elena, Macdonald, Robert Loch

“…Delayed cerebral vasospasm after subarachnoid hemorrhage is primarily due to sustained contraction of arterial smooth muscle cells. Its pathogenesis remains…”
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Different effects of clazosentan on consequences of subarachnoid hemorrhage in rats by Chen, Gang, Tariq, Asma, Ai, Jinglu, Sabri, Mohammed, Jeon, Hyo-jin, Tang, Elaine J.Y, Lakovic, Katarina, Wan, Hoyee, Macdonald, R. Loch

“…Abstract One of the major complications after subarachnoid hemorrhage (SAH) is angiographic vasospasm in the large arteries at the base of the brain. However,…”
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Purkinje Cell Vulnerability to Mild and Severe Forebrain Head Trauma by Park, Eugene, McKnight, Sarah, Ai, Jinglu, Baker, Andrew J

“…Pathophysiological changes in the cortex, thalamus, and hippocampus have been implicated as contributors to motor and cognitive deficits in a number of animal…”
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