Search Results - "JIN, Y."

Breaking T-cell tolerance in the immune system by Chen, Jin Y.

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The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development by Joshi, Amita, Ramanujan, Saroja, Jin, Jin Y.

“…Quantitative systems pharmacology (QSP) models are an important facet of pharmaceutical and clinical research as they combine mechanistic models of physiology…”
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A comprehensive survey of fitness approximation in evolutionary computation by Jin, Y.

“…Evolutionary algorithms (EAs) have received increasing interests both in the academy and industry. One main difficulty in applying EAs to real-world…”
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Correlation between PD-L1 expression and clinicopathological characterization in NSCLC by Jin, Y.

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Opportunities and Challenges of Disease Progression Modeling in Drug Development – An IQ Perspective by Goteti, Kosalaram, Hanan, Nathan, Magee, Mindy, Wojciechowski, Jessica, Mensing, Sven, Lalovic, Bojan, Hang, Yaming, Solms, Alexander, Singh, Indrajeet, Singh, Rajendra, Rieger, Theodore Robert, Jin, Jin Y.

“…Disease progression modeling (DPM) represents an important model‐informed drug development framework. The scientific communities support the use of DPM to…”
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Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure‐Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor) by Moein, Anita, Jin, Jin Y., Wright, Matthew R., Wong, Harvey

“…Cancer remains a significant global health challenge, and despite remarkable advancements in therapeutic strategies, poor tolerability of drugs (causing dose…”
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Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates by Ramakrishnan, Vidya, Friedrich, Christina, Witt, Colleen, Sheehan, Robert, Pryor, Meghan, Atwal, Jasvinder K., Wildsmith, Kristin, Kudrycki, Katherine, Lee, Seung‐Hye, Mazer, Norman, Hofmann, Carsten, Fuji, Reina N., Jin, Jin Y., Ramanujan, Saroja, Dolton, Michael, Quartino, Angelica

“…Despite considerable investment into potential therapeutic approaches for Alzheimer's disease (AD), currently approved treatment options are limited…”
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Everolimus Inhibits Anti‐HLA I Antibody‐Mediated Endothelial Cell Signaling, Migration and Proliferation More Potently Than Sirolimus by Jin, Y.‐P., Valenzuela, N. M., Ziegler, M. E., Rozengurt, E., Reed, E. F.

“…Antibody (Ab) crosslinking of HLA I molecules on the surface of endothelial cells triggers proliferative and pro‐survival intracellular signaling, which is…”
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Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer by Moein, Anita, Jin, Jin Y., Wright, Matthew R., Wong, Harvey

“…Purpose Among cases of breast cancer, estrogen receptor-positive (ER +), PIK3CA-mutant, HER2- advanced breast cancer stands as a particularly complex clinical…”
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Fractional statistics in anyon collisions by Bartolomei, H, Kumar, M, Bisognin, R, Marguerite, A, Berroir, J-M, Bocquillon, E, Plaçais, B, Cavanna, A, Dong, Q, Gennser, U, Jin, Y, Fève, G

“…Two-dimensional systems can host exotic particles called anyons whose quantum statistics are neither bosonic nor fermionic. For example, the elementary…”
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Metabolic engineering for improved fermentation of pentoses by yeasts by JEFFRIES, T. W, JIN, Y.-S

“…The fermentation of xylose is essential for the bioconversion of lignocellulose to fuels and chemicals, but wild-type strains of Saccharomyces cerevisiae do…”
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Nonlinear multilevel joint model for individual lesion kinetics and survival to characterize intra‐individual heterogeneity in patients with advanced cancer by Kerioui, Marion, Beaulieu, Maxime, Desmée, Solène, Bertrand, Julie, Mercier, François, Jin, Jin Y., Bruno, René, Guedj, Jérémie

“…In advanced cancer patients, tumor burden is calculated using the sum of the longest diameters (SLD) of the target lesions, a measure that lumps all lesions…”
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Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR‐SB by Jamalian, Samira, Dolton, Michael, Chanu, Pascal, Ramakrishnan, Vidya, Franco, Yesenia, Wildsmith, Kristin, Manser, Paul, Teng, Edmond, Jin, Jin Y., Quartino, Angelica, Hsu, Joy C.

“…There is strong interest in developing predictive models to better understand individual heterogeneity and disease progression in Alzheimer's disease (AD). We…”
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Support to early clinical decisions in drug development and personalised medicine with checkpoint inhibitors using dynamic biomarker-overall survival models by Bruno, René, Chanu, Pascal, Kågedal, Matts, Mercier, Francois, Yoshida, Kenta, Guedj, Jérémie, Li, Chunze, Beyer, Ulrich, Jin, Jin Y.

“…Longitudinal models of biomarkers such as tumour size dynamics capture treatment efficacy and predict treatment outcome (overall survival) of a variety of…”
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Artificial Intelligence: From Buzzword to Useful Tool in Clinical Pharmacology by Shahin, Mohamed H., Barth, Aline, Podichetty, Jagdeep T., Liu, Qi, Goyal, Navin, Jin, Jin Y., Ouellet, Daniele

“…The advent of artificial intelligence (AI) in clinical pharmacology and drug development is akin to the dawning of a new era. Previously dismissed as merely…”
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Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation by Budha, Nageshwar R., Ji, Tao, Musib, Luna, Eppler, Steve, Dresser, Mark, Chen, Yuan, Jin, Jin Y.

“…Background and Objectives Cobimetinib is eliminated mainly through cytochrome P450 (CYP) 3A4-mediated hepatic metabolism in humans. A clinical drug–drug…”
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Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease by Yoshida, Kenta, Moein, Anita, Bittner, Tobias, Ostrowitzki, Susanne, Lin, Helen, Honigberg, Lee, Jin, Jin Y, Quartino, Angelica

“…Crenezumab, a fully humanized anti-beta-amyloid (Aβ) immunoglobulin G4 (IgG4) monoclonal antibody, binds to both monomeric and aggregated forms of Aβ. We…”
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DEM study of mechanical characteristics of multi-spherical and superquadric particles at micro and macro scales by Soltanbeigi, Behzad, Podlozhnyuk, Alexander, Papanicolopulos, Stefanos-Aldo, Kloss, Christoph, Pirker, Stefan, Ooi, Jin Y.

“…Multi-spheres and Superquadrics are popular approaches for addressing particle shape effect in the Discrete Element Method (DEM). This study focuses on the…”
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Minimal-excitation states for electron quantum optics using levitons by Dubois, J., Jullien, T., Portier, F., Roche, P., Cavanna, A., Jin, Y., Wegscheider, W., Roulleau, P., Glattli, D. C.

“…Minimal-excitation fermionic quasiparticles are created by applying a potential with Lorentzian time dependence to the contact of a narrow constriction in a…”
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Three-Dimensional Dirac Phonons with Inversion Symmetry by Chen, Z J, Wang, R, Xia, B W, Zheng, B B, Jin, Y J, Zhao, Yu-Jun, Xu, H

“…Dirac semimetals associated with bulk Dirac fermions are well known in topological electronic systems. In sharp contrast, three-dimensional (3D) Dirac phonons…”
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