Search Results - "JIAOTI HUANG"

The expanded role of fatty acid metabolism in cancer: new aspects and targets by Chen, Ming, Huang, Jiaoti

“…Abstract Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and…”
Get full text

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage by Park, Jung Wook, Lee, John K, Sheu, Katherine M, Wang, Liang, Balanis, Nikolas G, Nguyen, Kim, Smith, Bryan A, Cheng, Chen, Tsai, Brandon L, Cheng, Donghui, Huang, Jiaoti, Kurdistani, Siavash K, Graeber, Thomas G, Witte, Owen N

“…The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms, including the…”
Get full text

Glycosylation Changes in Prostate Cancer Progression by Butler, William, Huang, Jiaoti

“…Prostate Cancer (PCa) is the most commonly diagnosed malignancy and second leading cause of cancer-related mortality in men. With the use of next generation…”
Get full text

Predicting clinical outcome of therapy-resistant prostate cancer by Ma, Xin, Huang, Jiaoti

Get full text

Morphologic Spectrum of Neuroendocrine Tumors of the Prostate: An Updated Review by Hu, Jing, Han, Bo, Huang, Jiaoti

“…The incidence of neuroendocrine tumors of the prostate increases after hormonal therapy. Neuroendocrine tumors possess a broad spectrum of morphologic features…”
Get full text

FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate by Park, Jung Wook, Lee, John K, Witte, Owen N, Huang, Jiaoti

“…The median survival of patients with small cell neuroendocrine carcinoma is significantly shorter than that of patients with classic acinar-type…”
Get full text

Aggressive Variants of Castration-Resistant Prostate Cancer by BELTRAN, Himisha, TOMLINS, Scott, LOGOTHETIS, Christopher, RUBIN, Mark A, APARICIO, Ana, ARORA, Vivek, RICKMAN, David, AYALA, Gustavo, HUANG, Jiaoti, TRUE, Lawrence, GLEAVE, Martin E, SOULE, Howard

“…A subset of patients with advanced castration-resistant prostate cancer may eventually evolve into an androgen receptor (AR)-independent phenotype, with a…”
Get full text

Functional expression of sodium-glucose transporters in cancer by Scafoglio, Claudio, Bruce A. Hirayama, Vladimir Kepe, Jie Liu, Chiara Ghezzi, Nagichettiar Satyamurthy, Neda A. Moatamed, Jiaoti Huang, Hermann Koepsell, Jorge R. Barrio, Ernest M. Wright

“…Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters…”
Get full text

Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study by Aggarwal, Rahul, Huang, Jiaoti, Alumkal, Joshi J, Zhang, Li, Feng, Felix Y, Thomas, George V, Weinstein, Alana S, Friedl, Verena, Zhang, Can, Witte, Owen N, Lloyd, Paul, Gleave, Martin, Evans, Christopher P, Youngren, Jack, Beer, Tomasz M, Rettig, Matthew, Wong, Christopher K, True, Lawrence, Foye, Adam, Playdle, Denise, Ryan, Charles J, Lara, Primo, Chi, Kim N, Uzunangelov, Vlado, Sokolov, Artem, Newton, Yulia, Beltran, Himisha, Demichelis, Francesca, Rubin, Mark A, Stuart, Joshua M, Small, Eric J

“…Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern…”
Get full text

Identification of a Cell of Origin for Human Prostate Cancer by Goldstein, Andrew S., Huang, Jiaoti, Guo, Changyong, Garraway, Isla P., Witte, Owen N.

“…Luminal cells are believed to be the cells of origin for human prostate cancer, because the disease is characterized by luminal cell expansion and the absence…”
Get full text

Value of Targeted Prostate Biopsy Using Magnetic Resonance–Ultrasound Fusion in Men with Prior Negative Biopsy and Elevated Prostate-specific Antigen by Sonn, Geoffrey A, Chang, Edward, Natarajan, Shyam, Margolis, Daniel J, Macairan, Malu, Lieu, Patricia, Huang, Jiaoti, Dorey, Frederick J, Reiter, Robert E, Marks, Leonard S

“…Abstract Background Conventional biopsy fails to detect the presence of some prostate cancers (PCas). Men with a prior negative biopsy but persistently…”
Get full text

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer by Chen, Ke, Xiao, Haibing, Zeng, Jin, Yu, Gan, Zhou, Hui, Huang, Chunhua, Yao, Weimin, Xiao, Wei, Hu, Junhui, Guan, Wei, Wu, Lily, Huang, Jiaoti, Huang, Qihong, Xu, Hua, Ye, Zhangqun

“…Deregulation or mutation of the gene causes various tumors, including clear cell renal cell carcinoma (ccRCC). Although several splice variants of EZH2 have…”
Get full text

Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer by Ren, Shancheng, Liu, Yawei, Xu, Weidong, Sun, Yi, Lu, Ji, Wang, Fubo, Wei, Min, Shen, Jian, Hou, Jianguo, Gao, Xu, Xu, Chuanliang, Huang, Jiaoti, Zhao, Yi, Sun, Yinghao

“…To understand the role of MALAT-1 in prostate cancer we evaluated its expression in prostate cancer tissues and cell lines. We also studied the therapeutic…”
Get more information

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/ Progenitor Cells by MULHOLLAND, David J, KOBAYASHI, Naoko, RUSCETTI, Marcus, ALLEN ZHI, TRAN, Linh M, JIAOTI HUANG, GLEAVE, Martin, HONG WU

“…PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models,…”
Get full text

Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure by Hu, Chang-Deng, Choo, Richard, Huang, Jiaoti

“…Neuroendocrine differentiation (NED) in prostate cancer is a well-recognized phenotypic change by which prostate cancer cells transdifferentiate into…”
Get full text

Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation by Ma, Yongjie, Zha, Junyi, Yang, XiangKun, Li, Qianjin, Zhang, Qingfu, Yin, Amelia, Beharry, Zanna, Huang, Hanwen, Huang, Jiaoti, Bartlett, Michael, Ye, Kaixiong, Yin, Hang, Cai, Houjian

“…Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Long-chain fatty…”
Get full text

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression by Gan, Wenjian, Dai, Xiangpeng, Lunardi, Andrea, Li, Zhen, Inuzuka, Hiroyuki, Liu, Pengda, Varmeh, Shoreh, Zhang, Jinfang, Cheng, Liang, Sun, Yin, Asara, John M., Beck, Andrew H., Huang, Jiaoti, Pandolfi, Pier Paolo, Wei, Wenyi

“…The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism…”
Get full text

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 by Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L, Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H, Wang, Liewei, Wild, Peter J, Garraway, Levi A, Rubin, Mark A, Barbieri, Christopher E, Wong, Kwok-Kin, Muthuswamy, Senthil K, Huang, Jiaoti, Chen, Yu, Bradner, James E, Wei, Wenyi

“…Recurrent mutations in SPOP -encoding a Cullin 3-based E3 ubiquitin ligase- in prostate cancer disrupt the recognition and degradation of ubiquitination…”
Get full text

RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis by Wang, Mu-En, Chen, Jiaqi, Lu, Yi, Bawcom, Alyssa R, Wu, Jinjin, Ou, Jianhong, Asara, John M, Armstrong, Andrew J, Wang, Qianben, Li, Lei, Wang, Yuzhuo, Huang, Jiaoti, Chen, Ming

“…Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate…”
Get full text

Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling by Chen, Zhong, Hankey, William, Zhao, Yue, Groth, Jeff, Huang, Furong, Wang, Hongyan, Campos, Alexandre Rosa, Huang, Jiaoti, Roeder, Robert G., Wang, Qianben

“…RNA Polymerase II (Pol II) transcriptional recycling is a mechanism for which the required factors and contributions to overall gene expression levels are…”
Get full text