Search Results - "JIANSHA LI"
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Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells
Published in Cancer research (Chicago, Ill.) (01-12-2010)“…Berberine, a natural product derived from a plant used in Chinese herbal medicine, is reported to exhibit anticancer effects; however, its mechanism of action…”
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2
Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer
Published in Oncotarget (26-04-2016)“…Triptolide has been shown to exhibit anticancer activity. However, its mechanism of action is not clearly defined. Herein we report a novel signaling pathway,…”
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3
How single-cell techniques help us look into lung cancer heterogeneity and immunotherapy
Published in Frontiers in immunology (21-08-2023)“…Lung cancer patients tend to have strong intratumoral and intertumoral heterogeneity and complex tumor microenvironment, which are major contributors to the…”
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Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor
Published in Journal of the American Heart Association (01-04-2017)“…Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline-induced pulmonary…”
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5
Mitochondrial transplantation attenuates hypoxic pulmonary hypertension
Published in Oncotarget (02-08-2016)“…Mitochondria are essential for the onset of hypoxia-induced pulmonary vasoconstriction and pulmonary vascular-remodeling, two major aspects underlying the…”
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6
Partial reduction of interleukin‐33 signaling improves senescence and renal injury in diabetic nephropathy
Published in MedComm (2020) (01-11-2024)“…Diabetic nephropathy (DN) is a frequent and costly complication of diabetes with limited understandings of mechanisms and therapies. Emerging evidence points…”
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Orally‐administrated mitochondria attenuate pulmonary hypertension with the aid of erythrocytes as carriers
Published in Clinical and translational medicine (01-09-2022)“…[...]the peptides-1, -3, -5 were used in subsequent experiments. In rats under chronic hypoxia exposure or treated with a single intraperitoneal injection of…”
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Calcium Sensing Receptor Inhibits Growth of Human Lung Adenocarcinoma Possibly via the GSK3β/Cyclin D1 Pathway
Published in Frontiers in cell and developmental biology (25-06-2020)“…The effect of calcium sensing receptor (CaSR) on tumor cell proliferation has been studied in several human cancers, and great discrepancies were found in…”
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Case Report: "Area of Focus" Atypical Trichinellosis and Fascioliasis Coinfection
Published in Frontiers in medicine (11-05-2022)“…Parasitic co-infection is commonly observed in natural populations, yet rare in the laboratory. Multiparasitism can have negative effects on the host, ranging…”
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10
Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model
Published in Thrombosis research (01-05-2015)“…Abstract Instruction Acute pulmonary thromboembolism (APTE) is a common clinical condition associated with significant morbidity and mortality. Although…”
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Berberine represses DAXX gene transcription and induces cancer cell apoptosis
Published in Laboratory investigation (01-03-2013)Get full text
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12
Cigarette smoke extract induces activation of β-catenin/TCF signaling through inhibiting GSK3β in human alveolar epithelial cell line
Published in Toxicology letters (22-05-2009)“…Cigarette smoke is known to have various injurious and cytotoxic effects on alveolar epithelial cells. However, the mechanism about the effects caused by…”
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13
Involvement of p120 in LPS-induced NF-κB activation and IL-8 production in human bronchial epithelial cells
Published in Toxicology letters (19-05-2010)“…P120-catenin (p120), a prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins, not only participates in cell–cell adhesion, but also…”
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14
Glycogen synthase kinase 3β and β-catenin are involved in the injury and repair of bronchial epithelial cells induced by scratching
Published in Experimental and molecular pathology (01-08-2007)“…The ability of airway epithelium to repair itself is an important step in the resolution of airway inflammation and diseases. To explore the cellular and…”
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Phenylalanine induces pulmonary hypertension through calcium-sensing receptor activation
Published in American journal of physiology. Lung cellular and molecular physiology (01-12-2020)“…Phenylalanine levels are associated with pulmonary hypertension in metabolic profiling clinical studies. However, the pathophysiological role of phenylalanine…”
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Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer
Published in Breast cancer research : BCR (09-03-2017)“…Mouse double minute 2 (MDM2) and vascular endothelial growth factor (VEGF) are important molecules involved in tumor progression. We researched potential…”
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A Hot White Dwarf SDSS J134430.11+032423.1 with a Planetary Debris Disk
Published in The Astrophysical journal (10-02-2017)“…We discovered a debris disk around hot white dwarf (WD) SDSS J134430.11+032423.1 (SDSS J1344+0324). The effective temperature 26,071( 163) K], surface gravity…”
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FKBP12 is a predictive biomarker for efficacy of anthracycline-based chemotherapy in breast cancer
Published in Cancer chemotherapy and pharmacology (01-10-2019)“…Background FK506-binding protein 12 (FKBP12) is abundant, ubiquitously expressed cytoplasmic protein with multiple functions in cell signaling transduction…”
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Determination of 23 Amino Acids and Amines in Plasma and Cortex of C57BL/6 Mice with HPLC–FLD
Published in Journal of chromatographic science (30-12-2023)“…Abstract Using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate as a pre-column derivatization reagent, optimized derivatization and chromatography parameters,…”
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Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer
Published in Angiogenesis (London) (01-01-2014)“…Background Mouse double minute 2 (MDM2) is overexpressed in many malignant tumors, and MDM2 levels are associated with poor prognosis of several human cancers,…”
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