Search Results - "JIANHUI RONG"

Therapeutic Potential of Heme Oxygenase-1/carbon Monoxide System Against Ischemia-Reperfusion Injury by Cheng, Yuanyuan, Rong, Jianhui

“…Ischemia-reperfusion (I/R) injury causes the dysfunctions of different major organs, leading to morbidity and mortality on the global scale. Among a battery of…”
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Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation by Qi, Hongyi, Han, Yifan, Rong, Jianhui

“…Many phytochemicals may ameliorate neurological disorders through a hormetic mechanism. The aim of this study was to characterize the hormetic role of…”
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Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice by Luo, Dan, Fan, Ni, Zhang, Xiuying, Ngo, Fung Yin, Zhao, Jia, Zhao, Wei, Huang, Ming, Li, Ding, Wang, Yu, Rong, Jianhui

“…Targeting endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may halt the pathogenesis of obesity and thereby reduce the prevalence of…”
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Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge by Zhao, Jia, Lao, Lixing, Cui, Wei, Rong, Jianhui

“…Bacterial infection is a potential risk factor for depression. However, little is known about the mechanistic link between bacterial endotoxin and…”
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Dissecting the molecular mechanisms underlying the antidepressant activities of herbal medicines through the comprehensive review of the recent literatures by Sun, Yilu, Zhao, Jia, Rong, Jianhui

“…Depression is clinically defined as a mood disorder with persistent feeling of sadness, despair, fatigue, and loss of interest. The pathophysiology of…”
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Generation of a RRAGA knockout human iPSC line GIBHi002-A-5 using CRISPR/Cas9 technology by Sun, Yilu, Fu, Jian, Yang, Jiayin, Zhao, Jia, Rong, Jianhui

“…Ras-related GTP-binding protein A (RagA), encoded by RRAGA gene, initially senses the availability of cellular amino acids (e.g., leucine) and controls the…”
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SUMOylation as a Therapeutic Target for Myocardial Infarction by Zhao, Wei, Zhang, Xiuying, Rong, Jianhui

“…Myocardial infarction is a prevalent and life-threatening cardiovascular disease. The main goal of existing interventional therapies is to restore coronary…”
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Upregulation of Small Ubiquitin-Like Modifier 2 and Protein SUMOylation as a Cardioprotective Mechanism Against Myocardial Ischemia-Reperfusion Injury by Zhao, Wei, Zhao, Jia, Zhang, Xiuying, Fan, Ni, Rong, Jianhui

“…Background: Small ubiquitin-like modifier (SUMO) proteins modify proteins through SUMOylation as an essential protein post-translational modification (PTM) for…”
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Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling by Zhao, Yingke, Luo, Dan, Ning, Zhipeng, Rong, Jianhui, Lao, Lixing

“…Neurotrophins, such as brain-derived neurotrophic factor (BDNF), have shown promise as neuroprotective agents, indicating their potential in therapeutic…”
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Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage by Tong, Ka Yan, Zhao, Jia, Tse, Chun-Wai, Wan, Pui-Ki, Rong, Jianhui, Au-Yeung, Ho Yu

“…The development of a new triggered-release system for selective detection of catecholamines in biological samples including living cells is reported…”
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In Silico Prediction of Quercetin Analogs for Targeting Death-Associated Protein Kinase 1 (DAPK1) Against Alzheimer's Disease by Sun, Yilu, Zhao, Jia, Lu, Yizhu, Ngo, Fung Yin, Shuai, Bo, Zhang, Zhang-Jin, Feng, Yibin, Rong, Jianhui

“…Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that greatly affects the health and life quality of the elderly population. Existing drugs…”
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A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction by Zhang, Xiuying, Chen, Qilei, Zhao, Jia, Zhao, Wei, Fan, Ni, Wang, Yu, Chen, Hubiao, Rong, Jianhui

“…Myocardial infarction (MI) is a highly prevalent and lethal disease worldwide. Prevention and timely recovery are critical for the control of the recurrence…”
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Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases by Chan, Chi Lui, Sun, Yilu, Mao, Xiaowen, Chen, Hansen, Zhao, Jia, Rong, Jianhui

“…Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer,…”
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Molecular Diversity and Potential Anti-neuroinflammatory Activities of Cyathane Diterpenoids from the Basidiomycete Cyathus africanus by Wei, Jing, Cheng, Yuanyuan, Guo, Wan-Hui, Wang, Da-Cheng, Zhang, Qiang, Li, Ding, Rong, Jianhui, Gao, Jin-Ming

“…Ten new polyoxygenated cyathane diterpenoids, named neocyathins A–J ( 1 – 10 ), together with four known diterpenes ( 11 – 14 ), were isolated from the liquid…”
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A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases by Zhao, Jia, Zhu, Mengxia, Kumar, Mukesh, Ngo, Fung Yin, Li, Yinghui, Lao, Lixing, Rong, Jianhui

“…Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve…”
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Modified Qing’ e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation by Lu, Junjie, Hu, Desheng, Ma, Chen, Xu, Xiaojuan, Shen, Lin, Rong, Jianhui, Zhao, Jia, Shuai, Bo

“…Objective To explore whether the modified Qing’ e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis. Methods…”
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Identification of Steroidogenic Components Derived From Gardenia jasminoides Ellis Potentially Useful for Treating Postmenopausal Syndrome by Wang, Xueyu, Wang, Guo-Cai, Rong, Jianhui, Wang, Shi Wei, Ng, Tzi Bun, Zhang, Yan Bo, Lee, Kai Fai, Zheng, Lin, Wong, Hei-Kiu, Yung, Ken Kin Lam, Sze, Stephen Cho Wing

“…Estrogen-stimulating principles have been demonstrated to relieve postmenopausal syndrome effectively. Ellis (GJE) is an herbal medicine possessing multiple…”
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N-Propargyl Caffeamide Skews Macrophages Towards a Resolving M2-Like Phenotype Against Myocardial Ischemic Injury via Activating Nrf2/HO-1 Pathway and Inhibiting NF-ĸB Pathway by Cheng, Yuanyuan, Yang, Chuanbin, Luo, Dan, Li, Xuechen, Le, X. Chris, Rong, Jianhui 

“…Background/Aims: Macrophages exhibit dynamic pro-inflammatory and resolving activities in myocardial infarction. The present study investigated whether caffeic…”
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Releasing Nrf2 to promote neurite outgrowth by Yang, Chuanbin, Cheng, Yuanyuan, Zhao, Jiao, Rong, Jianhui

“…Roles of Keap1-Nrf2 pathway in brain：Neuronal survival and neurogenesis are impaired in neurodegenerative diseases such as Parkinson＇s disease and Alzheimer＇s…”
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Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase by Cui, Wei, Zhang, Zaijun, Li, Wenming, Mak, Shinghung, Hu, Shengquan, Zhang, Huan, Yuan, Shuai, Rong, Jianhui, Choi, Tony Chunglit, Lee, Simon M Y, Han, Yifan

“…SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this…”
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