Search Results - "JI YUAN"
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Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis
Published in Cell metabolism (04-08-2020)“…The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and…”
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Immunological and inflammatory profiles in mild and severe cases of COVID-19
Published in Nature communications (08-07-2020)“…COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been…”
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TCGA-Assembler: open-source software for retrieving and processing TCGA data
Published in Nature methods (01-06-2014)Get full text
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Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
Published in Cancer research (Chicago, Ill.) (15-12-2014)“…High concentrations of adenosine in tumor microenvironments inhibit antitumor cytotoxic lymphocyte responses. Although T cells express inhibitory adenosine A2A…”
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Single-cell landscape of immunological responses in patients with COVID-19
Published in Nature immunology (01-09-2020)“…In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease…”
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Dodecaborane‐Based Dopants Designed to Shield Anion Electrostatics Lead to Increased Carrier Mobility in a Doped Conjugated Polymer
Published in Advanced materials (Weinheim) (01-03-2019)“…One of the most effective ways to tune the electronic properties of conjugated polymers is to dope them with small‐molecule oxidizing agents, creating holes on…”
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One‐Step Access to Sequence‐Controlled Block Copolymers by Self‐Switchable Organocatalytic Multicomponent Polymerization
Published in Angewandte Chemie International Edition (17-12-2018)“…A one‐step procedure for the self‐switchable block copolymerization of monomer mixtures of epoxides, cyclic anhydrides, and lactide (LA) was developed by using…”
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Oxygen Vacancies and Interface Engineering on Amorphous/Crystalline CrOx‐Ni3N Heterostructures toward High‐Durability and Kinetically Accelerated Water Splitting
Published in Small (Weinheim an der Bergstrasse, Germany) (01-04-2022)“…Manipulating catalytic active sites and reaction kinetics in alkaline media is crucial for rationally designing mighty water‐splitting electrocatalysts with…”
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Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell‐like property of hepatocellular carcinoma cells by stabilizing NOP2
Published in Hepatology (Baltimore, Md.) (01-10-2014)“…Many protein‐coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult liver. The protein products of these hepatic…”
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Self-supported bimetallic phosphides with artificial heterointerfaces for enhanced electrochemical water splitting
Published in Applied catalysis. B, Environmental (01-05-2022)“…Rational design and exploitation of efficient and inexpensive catalysts for water electrolysis are highly desired, yet very challenging. Herein, for the first…”
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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
Published in Nature (London) (01-05-2019)“…Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 – 4 . The detection of pathogen-derived nucleic acids is a central…”
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METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing
Published in Hepatology (Baltimore, Md.) (01-02-2017)“…N6‐Methyladenosine (m6A) modification has been implicated in many biological processes. However, its role in cancer has not been well studied. Here, we…”
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Asymmetric Catalytic 1,6-Conjugate Addition/Aromatization of para-Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers
Published in Angewandte Chemie International Edition (26-08-2013)“…It′s just a phase: The title reaction sequence of para‐quinone methides (p‐QMs) has been developed with malonates under phase‐transfer catalysis. The reaction…”
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Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)
Published in Cell death and differentiation (01-11-2020)“…SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The pathogenesis of severe cases remains unknown. We performed an in-depth…”
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Exploitation of a Half-Conjugate Polydentate Salamo–Salen Hybrid Ligand and Its Two Phenoxide-Bridged Heterohexanuclear 3d–s Double-Helical Cluster Complexes
Published in Inorganic chemistry (17-01-2022)“…A half-conjugate polydentate Salamo–Salen hybrid ligand, H 5 L, containing two unique N2O2 pockets was first designed so that these metal ions in the complexes…”
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Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
Published in The FEBS journal (01-10-2016)“…Long noncoding RNA (lncRNA) have critical roles in various pathophysiological processes, and are frequently dysregulated in many diseases, particularly in…”
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TCGA-assembler 2: software pipeline for retrieval and processing of TCGA/CPTAC data
Published in Bioinformatics (01-05-2018)“…Abstract Motivation The Cancer Genome Atlas (TCGA) program has produced huge amounts of cancer genomics data providing unprecedented opportunities for…”
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Germanium as key dopant to boost the catalytic performance of small platinum clusters for alkane dehydrogenation
Published in Journal of catalysis (01-06-2019)“…[Display omitted] •We present an effective, cheap and green way of tailoring platinum’s performance for alkane dehydrogenation.•Doping Pt with Ge improves the…”
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Probability intervals of toxicity and efficacy design for dose-finding clinical trials in oncology
Published in Statistical methods in medical research (01-03-2021)“…Immunotherapy, gene therapy or adoptive cell therapies, such as the chimeric antigen receptor+ T-cell therapies, have demonstrated promising therapeutic…”
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