Search Results - "JEWELL, Laurence D"

The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when? by Gilbert, M Thomas P, Haselkorn, Tamara, Bunce, Michael, Sanchez, Juan J, Lucas, Sebastian B, Jewell, Laurence D, Van Marck, Eric, Worobey, Michael

“…Museums and pathology collections around the world represent an archive of genetic material to study populations and diseases. For preservation purposes, a…”
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Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis by Jijon, H B, Churchill, T, Malfair, D, Wessler, A, Jewell, L D, Parsons, H G, Madsen, K L

“…Crohn's disease is a chronic disease characterized by oxidant-induced tissue injury and increased intestinal permeability. A consequence of oxidative damage is…”
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Alleviating Intestinal Ischemia-Reperfusion Injury in an In Vivo Large Animal Model : Developing an Organ-Specific Preservation Solution by SALEHI, Payam, BIGAM, David L, EWASCHUK, Julia B, MADSEN, Karen L, SIGURDSON, Grant T, JEWELL, Laurence D, CHURCHILL, Thomas A

“…This study investigated the role of a novel nutrient-rich preservation solution in alleviating intestinal ischemia-reperfusion (IR) injury in a large animal…”
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Relationship between energetic stress and pro-apoptotic/cytoprotective kinase mechanisms in intestinal preservation by Salehi, Payam, MD, PhD, Walker, John, PhD, Madsen, Karen L., PhD, Sigurdson, Grant T., MD, Strand, Berit L., PhD, Christensen, Bjørn E., PhD, Jewell, Laurence D., MD, FRCPC, Churchill, Thomas A., PhD

“…Background A recent study from our laboratory documented significant improvements in post-transplant viability in an experimental model of intestinal…”
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Defining the Role of a Tailored Luminal Solution for Small Bowel Preservation by Fujimoto, Yasuhiro, Olson, David W., Madsen, Karen L., Zeng, Janice, Jewell, Laurence D., Kneteman, Norman M., Bigam, David L., Churchill, Thomas A.

“…The mucosal layer is the initial site of small bowel (SB) graft injury sustained during cold storage. Vascular administration of preservation solutions alone…”
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Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice by Madsen, Karen L., Doyle ‡, Jason S., Jewell ‡, Laurence D., Tavernini, Michele M., Fedorak, Richard N.

“…Background & Aims: Intestinal luminal microflora, or their products, are likely an important initiating factor in the pathogenesis of inflammatory bowel…”
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Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen by Joynt, Chloë, Bigam, David L., Charrois, Gregory, Jewell, Laurence D., Korbutt, Gregory, Cheung, Po-Yin

“…Background After resuscitation, asphyxiated neonates often develop poor cardiac function with hypotension, pulmonary hypertension and multiorgan ischemia. In a…”
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Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation by Joynt, Chloë, Bigam, David L., Charrois, Gregory, Jewell, Laurence D., Korbutt, Gregory, Cheung, Po-Yin

“…Objective Neonatal asphyxia causes cardiogenic shock and pulmonary hypertension with decreased brain perfusion. We examined the dose-response of milrinone on…”
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N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen by Johnson, Scott T, Bigam, David L, Emara, Marwan, Obaid, Laila, Slack, Graham, Korbutt, Gregory, Jewell, Laurence D, Van Aerde, John, Cheung, Po-Yin

“…Neonatal asphyxia may lead to cardiac and renal complications perhaps mediated by oxygen free radicals. Using a model of neonatal hypoxia-reoxygenation, we…”
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Multiplex PCR with minisequencing as an effective high-throughput SNP typing method for formalin-fixed tissue by Gilbert, Marcus T. P., Sanchez, Juan J., Haselkorn, Tamara, Jewell, Laurence D., Lucas, Sebastian B., Van Marck, Eric, Børsting, Claus, Morling, Niels, Worobey, Michael

“…Extensive collections of formalin‐fixed paraffin‐embedded (FFPE) tissues exist that could be exploited for genetic analyses in order to provide important…”
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Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: a dose-response study by Joynt, Chloë, Bigam, David L, Charrois, Gregory, Jewell, Laurence D, Korbutt, Gregory, Cheung, Po-Yin

“…Neonatal asphyxia can result in poor perfusion, vasoconstriction, and decreased oxygen delivery in the intestine. Milrinone increases myocardial contractility…”
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Resuscitation with 100% oxygen causes intestinal glutathione oxidation and reoxygenation injury in asphyxiated Newborn piglets by HAASE, Erika, BIGAM, David L, NAKONECHNY, Quentin B, JEWELL, Laurence D, KORBUTT, Gregory, CHEUNG, Po-Yin

“…To compare mesenteric blood flow, oxidative stress, and mucosal injury in piglet small intestine during hypoxemia and reoxygenation with 21%, 50%, or 100%…”
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Effects of N-acetylcysteine on intestinal reoxygenation injury in hypoxic newborn piglets resuscitated with 100% oxygen by Johnson, Scott T, Bigam, David L, Emara, Marwan, Slack, Graham, Jewell, Laurence D, Obaid, Laila, Korbutt, Gregory, Van Aerde, John, Cheung, Po-Yin

“…Neonatal asphyxia may lead to the development of ischemia-reperfusion induced intestinal injury, which is related to oxygen-derived free radical production…”
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Human small bowel storage: the role for luminal preservation solutions by Olson, David W, Jijon, Humberto, Madsen, Karen L, Al-Saghier, Mohammed, Zeng, Janice, Jewell, Laurence D, Bigam, David L, Churchill, Thomas A

“…Graft injury incurred during periods of cold storage remains a factor affecting the success of small bowel (SB) transplantation. No one preservation solution,…”
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Predicting the liver histology in chronic hepatitis C: how good is the clinician? by Romagnuolo, Joseph, Jhangri, Gian S, Jewell, Laurence D, Bain, Vincent G

“…Liver biopsy is believed to be necessary before antiviral treatment in hepatitis C. Studies have found symptoms and biochemistry poorly predictive of grade and…”
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Fish oil-enriched diet is mucosal protective against acetic acid-induced colitis in rats by Empey, L R, Jewell, L D, Garg, M L, Thomson, A B, Clandinin, M T, Fedorak, R N

“…Products of arachidonic acid metabolism are elevated in patients with inflammatory bowel disease and this elevation is correlated with disease activity…”
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Intestinal decontamination using povidone-iodine compromises small bowel storage quality by OLSON, David W, KADOTA, Shin, CORNISH, Anthony, MADSEN, Karen L, ZENG, Janice, JEWELL, Laurence D, BIGAM, David L, CHURCHILL, Thomas A

“…Povidone-iodine (PI) (Betadine, Purdue Fredrick Co., Norwalk, CT) is used during pancreas transplantation to provide duodenal decontamination without any…”
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Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression by Fedorak, R N, Haeberlin, B, Empey, L R, Cui, N, Nolen, 3rd, H, Jewell, L D, Friend, D R

“…Dexamethasone-beta-D-glucuronide, a colon-specific prodrug of dexamethasone, may be useful in the treatment of ulcerative colitis and Crohn's colitis. The aim…”
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Interleukin‐10 gene‐deficient mice develop a primary intestinal permeability defect in response to enteric microflora by Madsen, Karen L., Malfair, David, Gray, Derek, Doyle, Jason S., Jewell, Laurence D., Fedorak, Richard N.

“…The normal intestinal epithelium provides a barrier relatively impermeable to luminal constituents. However, patients with inflammatory bowel disease…”
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Hemorrhagic intestinal Henoch-Schonlein purpura complicated by cytomegalovirus infection by Nguyen-Ho, P, Jewell, L D, Thomson, A B

“…A 54-year-old man on hemodialysis for acute chronic renal failure and on corticosteroids for Henoch-Schonlein purpura developed massive hematochezia. After…”
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