Search Results - "JERSE, Ann E"

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae by Leduc, Isabelle, Connolly, Kristie L, Begum, Afrin, Underwood, Knashka, Darnell, Stephen, Shafer, William M, Balthazar, Jacqueline T, Macintyre, Andrew N, Sempowski, Gregory D, Duncan, Joseph A, Little, Marguerite B, Rahman, Nazia, Garges, Eric C, Jerse, Ann E

“…There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of…”
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Progress Toward a Gonococcal Vaccine: The Way Forward by Russell, Michael W, Jerse, Ann E, Gray-Owen, Scott D

“…The concept of immunizing against gonorrhea has received renewed interest because of the recent emergence of strains of that are resistant to most currently…”
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Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production by Baarda, Benjamin I, Zielke, Ryszard A, Le Van, Adriana, Jerse, Ann E, Sikora, Aleksandra E

“…The six-component maintenance of lipid asymmetry (Mla) system is responsible for retrograde transport of phospholipids, ensuring the barrier function of the…”
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SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection by Zielke, Ryszard A, Le Van, Adriana, Baarda, Benjamin I, Herrera, Marco F, Acosta, Christopher J, Jerse, Ann E, Sikora, Aleksandra E

“…Lysozymes are nearly omnipresent as the first line of immune defense against microbes in animals. They exert bactericidal action through antimicrobial peptide…”
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Editorial: Immunity to Neisseria gonorrhoeae by Russell, Michael W, Gray-Owen, Scott D, Jerse, Ann E

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Challenges and Controversies Concerning Neisseria gonorrhoeae-Neutrophil Interactions in Pathogenesis by Criss, Alison K, Genco, Caroline A, Gray-Owen, Scott D, Jerse, Ann E, Seifert, H Steven

“…The bacterium Neisseria gonorrhoeae (Ngo) is the main cause of the sexually transmitted infection gonorrhea. The global incidence of 87 million new Ngo…”
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Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections by Jerse, Ann E, Wu, Hong, Packiam, Mathanraj, Vonck, Rachel A, Begum, Afrin A, Garvin, Lotisha E

“…Historically, animal modeling of gonorrhea has been hampered by the exclusive adaptation of Neisseria gonorrhoeae to humans. Genital tract infection can be…”
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Neisseria gonorrhoeae Coinfection during Chlamydia muridarum Genital Latency Does Not Modulate Murine Vaginal Bacterial Shedding by Onorini, Delia, Leonard, Cory Ann, Phillips Campbell, Regenia, Prähauser, Barbara, Pesch, Theresa, Schoborg, Robert V, Jerse, Ann E, Tarigan, Bernadetta, Borel, Nicole

“…Chlamydia trachomatis and Neisseria gonorrhoeae are the most frequently reported agents of bacterial sexually transmitted disease worldwide. Nonetheless, C…”
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Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC by Hobbs, Marcia M, Sparling, P Frederick, Cohen, Myron S, Shafer, William M, Deal, Carolyn D, Jerse, Ann E

“…Experimental infection of male volunteers with Neisseria gonorrhoeae is safe and reproduces the clinical features of naturally acquired gonococcal urethritis…”
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Opacity Proteins Increase Neisseria gonorrhoeae Fitness in the Female Genital Tract Due to a Factor under Ovarian Control by Cole, Jessica G, Fulcher, Nanette B, Jerse, Ann E

“…The neisserial opacity (Opa) proteins are a family of antigenically distinct outer membrane proteins that undergo phase-variable expression. Opa⁺ variants of…”
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Lipid-Modified Azurin of Neisseria gonorrhoeae Is Not Surface Exposed and Does Not Interact With the Nitrite Reductase AniA by Baarda, Benjamin I, Zielke, Ryszard A, Jerse, Ann E, Sikora, Aleksandra E

“…Lipid-modified cupredoxin azurin (Laz) is involved in electron transport in and proposed to act as an electron donor to the surface-displayed nitrite reductase…”
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Regulation of the MtrC-MtrD-MtrE Efflux-Pump System Modulates the In Vivo Fitness of Neisseria gonorrhoeae by Warner, Douglas M., Folster, Jason P., Shafer, William M., Jerse, Ann E.

“…The Neisseria gonorrhoeae MtrC-MtrD-MtrE multidrug-resistance efflux pump expels macrolide antibiotics, penicillin, and antimicrobial effectors of the innate…”
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A novel mechanism of high-level, broad-spectrum antibiotic resistance caused by a single base pair change in Neisseria gonorrhoeae by Ohneck, Elizabeth A, Zalucki, Yaramah M, Johnson, Paul J T, Dhulipala, Vijaya, Golparian, Daniel, Unemo, Magnus, Jerse, Ann E, Shafer, William M

“…The MtrC-MtrD-MtrE multidrug efflux pump of Neisseria gonorrhoeae confers resistance to a diverse array of antimicrobial agents by transporting these toxic…”
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Chlamydial Infection Increases Gonococcal Colonization in a Novel Murine Coinfection Model by Vonck, Rachel A, Darville, T, O'Connell, C.M, Jerse, Ann E

“…Genital tract infections caused by Neisseria gonorrhoeae and Chlamydia trachomatis serovars D to K occur at high incidence in many areas of the world. Despite…”
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Mouse Strain-Dependent Differences in Susceptibility to Neisseria gonorrhoeae Infection and Induction of Innate Immune Responses by Packiam, Mathanraj, Veit, Sandra J, Anderson, Deborah J, Ingalls, Robin R, Jerse, Ann E

“…Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci…”
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Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model by Broder, Kieran C., Matrosova, Vera Y., Tkavc, Rok, Gaidamakova, Elena K., Ho, Lam Thuy Vi Tran, Macintyre, Andrew N., Soc, Anthony, Diallo, Aissata, Darnell, Stephen C., Bash, Sarah, Daly, Michael J., Jerse, Ann E., Liechti, George W.

“…Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed,…”
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Vaccines for gonorrhea: can we rise to the challenge? by Zhu, Weiyan, Chen, Ching-Ju, Thomas, Christopher E, Anderson, James E, Jerse, Ann E, Sparling, P Frederick

“…Immune responses to the gonococcus after natural infection ordinarily result in little immunity to reinfection, due to antigenic variation of the gonococcus,…”
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Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development by Rice, Peter A, Shafer, William M, Ram, Sanjay, Jerse, Ann E

“…Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are emerging. Appropriate antimicrobial…”
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Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men by Hobbs, Marcia M, Anderson, James E, Balthazar, Jacqueline T, Kandler, Justin L, Carlson, Russell W, Ganguly, Jhuma, Begum, Afrin A, Duncan, Joseph A, Lin, Jessica T, Sparling, P Frederick, Jerse, Ann E, Shafer, William M

“…Phosphoethanolamine (PEA) on Neisseria gonorrhoeae lipid A influences gonococcal inflammatory signaling and susceptibility to innate host defenses in in vitro…”
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α-2,3-Sialyltransferase Enhances Neisseria gonorrhoeae Survival during Experimental Murine Genital Tract Infection by Wu, Hong, Jerse, Ann E

“…The addition of host-derived sialic acid to Neisseria gonorrhoeae lipooligosaccharide is hypothesized to be an important mechanism by which gonococci evade…”
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