Search Results - "JENSEN, Trine"

CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRi by Bendixen, Louise, Jensen, Trine I., Bak, Rasmus O.

“…The CRISPR-Cas system is commonly known for its ability to cleave DNA in a programmable manner, which has democratized gene editing and facilitated recent…”
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Natural RNA circles function as efficient microRNA sponges by Hansen, Thomas B., Jensen, Trine I., Clausen, Bettina H., Bramsen, Jesper B., Finsen, Bente, Damgaard, Christian K., Kjems, Jørgen

“…A natural circular RNA termed ciRS-7 is shown to function as a negative regulator of microRNA; ciRS-7 acts as an efficient sponge for the microRNA miR-7, and…”
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Therapeutic gene editing in haematological disorders with CRISPR/Cas9 by Jensen, Trine I., Axelgaard, Esben, Bak, Rasmus O.

“…Summary The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR‐associated (Cas)9 platform offers an efficient way of making precise…”
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Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi by Jensen, Trine I, Mikkelsen, Nanna S, Gao, Zongliang, Foßelteder, Johannes, Pabst, Gabriel, Axelgaard, Esben, Laustsen, Anders, König, Saskia, Reinisch, Andreas, Bak, Rasmus O

“…Targeted transcriptional activation or interference can be induced with the CRISPR-Cas9 system (CRISPRa/CRISPRi) using nuclease-deactivated Cas9 fused to…”
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Centennial response of Greenland’s three largest outlet glaciers by Khan, Shfaqat A., Bjørk, Anders A., Bamber, Jonathan L., Morlighem, Mathieu, Bevis, Michael, Kjær, Kurt H., Mouginot, Jérémie, Løkkegaard, Anja, Holland, David M., Aschwanden, Andy, Zhang, Bao, Helm, Veit, Korsgaard, Niels J., Colgan, William, Larsen, Nicolaj K., Liu, Lin, Hansen, Karina, Barletta, Valentina, Dahl-Jensen, Trine S., Søndergaard, Anne Sofie, Csatho, Beata M., Sasgen, Ingo, Box, Jason, Schenk, Toni

“…The Greenland Ice Sheet is the largest land ice contributor to sea level rise. This will continue in the future but at an uncertain rate and observational…”
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Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma by Jensen, Trine O., Schmidt, Henrik, Møller, Holger J., Donskov, Frede, Høyer, Morten, Sjoegren, Pia, Christensen, Ib J., Steiniche, Torben

“…BACKGROUND: Tumor cell and host immune cell interaction plays a key role in carcinogenesis. Signal transducer and activator of transcription 3 (STAT3) is…”
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Novel nucleotide-packaging vaccine delivers antigen and poly(I:C) to dendritic cells and generate a potent antibody response in vivo by Bruun, Natasja, Laursen, Marlene F., Carmelo, Rita, Christensen, Esben, Jensen, Trine S., Christiansen, Gunna, Birkelund, Svend, Agger, Ralf, Kofod-Olsen, Emil

“…An issue with many current vaccines is the dependency on broadly inflammatory adjuvants, such as aluminum hydroxide or aluminum salts that affect many immune-…”
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Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma by JENSEN, Trine O, SCHMIDT, Henrik, MØLLER, Holger Jon, HOYER, Morten, MANIECKI, Maciej Bogdan, SJOEGREN, Pia, CHRISTENSEN, Ib Jarle, STEINICHE, Torben

“…To evaluate the prognostic role of soluble CD163 (sCD163) in serum and macrophage infiltration in primary melanomas from patients with American Joint Committee…”
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses by He, Mingyu, Roussak, Kate, Ma, Feiyang, Borcherding, Nicholas, Garin, Vince, White, Mike, Schutt, Charles, Jensen, Trine I, Zhao, Yun, Iberg, Courtney A, Shah, Kairav, Bhatia, Himanshi, Korenfeld, Daniel, Dinkel, Sabrina, Gray, Judah, Ulezko Antonova, Alina, Ferris, Stephen, Donermeyer, David, Lindestam Arlehamn, Cecilia, Gubin, Matthew M, Luo, Jingqin, Gorvel, Laurent, Pellegrini, Matteo, Sette, Alessandro, Tung, Thomas, Bak, Rasmus, Modlin, Robert L, Fields, Ryan C, Schreiber, Robert D, Allen, Paul M, Klechevsky, Eynav

“…The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB)…”
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Increasing use of computed tomography scans in the North Denmark Region raises patient safety concern by Westmark, Signe, Hessellund, Thomas, Hoffmann, Andreas, Madsen, Bjarne Borggaard, Jensen, Trine S., Gielen, Mahican, Bøggild, Henrik, Leutscher, Peter Derek Christian

“…Use of computed tomography (CT) scans raises safety concern as lifetime cumulative ionising radiation exposure is associated with risk of developing…”
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Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I/II melanoma by Nielsen, Patricia S, Riber-Hansen, Rikke, Jensen, Trine O, Schmidt, Henrik, Steiniche, Torben

“…Cellular proliferation is correlated with the progression of melanoma. Accordingly, the proliferation index of H&E-stained thin melanomas was recently included…”
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Argonaute-associated short introns are a novel class of gene regulators by Hansen, Thomas B., Venø, Morten T., Jensen, Trine I., Schaefer, Anne, Damgaard, Christian K., Kjems, Jørgen

“…MicroRNAs (miRNAs) are short (∼22 nucleotides) regulators of gene expression acting by direct base pairing to 3′-UTR target sites in messenger RNAs. Mature…”
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Aleutian mink disease virus in free-ranging mink from Sweden by Persson, Sara, Jensen, Trine H, Blomström, Anne-Lie, Appelberg, Mia Tjernström, Magnusson, Ulf

“…Aleutian mink disease (AMD) is a chronic viral disease in farmed mink and the virus (AMDV) has been found in many free-ranging mink (Neovison vison)…”
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Effects of Polar Bear and Killer Whale Derived Contaminant Cocktails on Marine Mammal Immunity by Desforges, Jean-Pierre, Levin, Milton, Jasperse, Lindsay, De Guise, Sylvain, Eulaers, Igor, Letcher, Robert J, Acquarone, Mario, Nordøy, Erling, Folkow, Lars P, Hammer Jensen, Trine, Grøndahl, Carsten, Bertelsen, Mads F, St. Leger, Judy, Almunia, Javier, Sonne, Christian, Dietz, Rune

“…Most controlled toxicity studies use single chemical exposures that do not represent the real world situation of complex mixtures of known and unknown natural…”
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Miocene uplift of the NE Greenland margin linked to plate tectonics: Seismic evidence from the Greenland Fracture Zone, NE Atlantic by Døssing, Arne, Japsen, Peter, Watts, Anthony B., Nielsen, Tove, Jokat, Wilfried, Thybo, Hans, Dahl‐Jensen, Trine

“…Tectonic models predict that following breakup, rift margins undergo only decaying thermal subsidence during their postrift evolution. However, postbreakup…”
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Climate-associated drivers of plasma cytokines and contaminant concentrations in Beaufort Sea polar bears (Ursus maritimus) by Bourque, Jennifer, Desforges, Jean-Pierre, Levin, Milton, Atwood, Todd C., Sonne, Christian, Dietz, Rune, Jensen, Trine H., Curry, Erin, McKinney, Melissa A.

“…Assessing polar bear (Ursus maritimus) immune function in relation to environmental stressors, including habitat change, nutritional stress, pathogen…”
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Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha by Hansen, Mariann F, Greibe, Eva, Skovbjerg, Signe, Rohde, Sarah, Kristensen, Anders C M, Jensen, Trine R, Stentoft, Charlotte, Kjær, Karina H, Kronborg, Camilla S, Martensen, Pia M

“…The signal transducer and activator of transcription 3 (STAT3) is a well-described pro-oncogene found constitutively activated in several cancer types. Folates…”
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Influenza A(H10N7) virus in dead harbor seals, Denmark by Krog, Jesper S, Hansen, Mette S, Holm, Elisabeth, Hjulsager, Charlotte K, Chriél, Mariann, Pedersen, Karl, Andresen, Lars O, Abildstrøm, Morten, Jensen, Trine H, Larsen, Lars E

“…Since April 2014, an outbreak of influenza in harbor seals has been ongoing in northern Europe. In Denmark during June-August, 152 harbor seals on the island…”
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Hepatitis E virus variant in farmed mink, Denmark by Krog, Jesper S, Breum, Solvej Ø, Jensen, Trine H, Larsen, Lars E

“…Hepatitis E virus (HEV) is a zoonotic virus for which pigs are the primary animal reservoir. To investigate whether HEV occurs in mink in Denmark, we screened…”
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Monitoring chronic infection with a field strain of Aleutian mink disease virus by Jensen, Trine Hammer, Hammer, Anne Sofie, Chriél, Mariann

“…Aleutian mink disease virus (AMDV) readily spread within farmed mink and causes chronic infections with significant impacts for welfare and economy. In the…”
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