Search Results - "JENSEN, Michael C"

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity by Jacoby, Elad, Nguyen, Sang M., Fountaine, Thomas J., Welp, Kathryn, Gryder, Berkley, Qin, Haiying, Yang, Yinmeng, Chien, Christopher D., Seif, Alix E., Lei, Haiyan, Song, Young K., Khan, Javed, Lee, Daniel W., Mackall, Crystal L., Gardner, Rebecca A., Jensen, Michael C., Shern, Jack F., Fry, Terry J.

“…Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in…”
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A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells by Wang, Xiuli, Chang, Wen-Chung, Wong, ChingLam W., Colcher, David, Sherman, Mark, Ostberg, Julie R., Forman, Stephen J., Riddell, Stanley R., Jensen, Michael C.

“…An unmet need in cell engineering is the availability of a single transgene encoded, functionally inert, human polypeptide that can serve multiple purposes,…”
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Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems by Chen, Yvonne Y, Jensen, Michael C, Smolke, Christina D

“…RNA molecules perform diverse regulatory functions in natural biological systems, and numerous synthetic RNA-based control devices that integrate sensing and…”
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Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma by Budde, Lihua E, Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E, Brouns, Shaunda A, Spencer, David M, Till, Brian G, Jensen, Michael C, Riddell, Stanley R, Press, Oliver W

“…Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of…”
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Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases by Osborn, Mark J, Webber, Beau R, Knipping, Friederike, Lonetree, Cara-lin, Tennis, Nicole, DeFeo, Anthony P, McElroy, Amber N, Starker, Colby G, Lee, Catherine, Merkel, Sarah, Lund, Troy C, Kelly-Spratt, Karen S, Jensen, Michael C, Voytas, Daniel F, von Kalle, Christof, Schmidt, Manfred, Gabriel, Richard, Hippen, Keli L, Miller, Jeffrey S, Scharenberg, Andrew M, Tolar, Jakub, Blazar, Bruce R

“…Present adoptive immunotherapy strategies are based on the re-targeting of autologous T-cells to recognize tumor antigens. As T-cell properties may vary…”
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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing by Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C, Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H, Künkele, Annette

“…Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical…”
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Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma by Parsa, Andrew T, Waldron, James S, Panner, Amith, Crane, Courtney A, Parney, Ian F, Barry, Jeffrey J, Cachola, Kristine E, Murray, Joseph C, Tihan, Tarik, Jensen, Michael C, Mischel, Paul S, Stokoe, David, Pieper, Russell O

“…Cancer immunoresistance and immune escape may play important roles in tumor progression and pose obstacles for immunotherapy. Expression of the…”
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Value Maximization, Stakeholder Theory, and the Corporate Objective Function by Jensen, Michael C.

“…In this article, I offer a proposal to clarify what I believe is the proper relation between value maximization and stakeholder theory, which I call…”
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Safety and immunologic effects of IL-15 administration in nonhuman primates by Berger, Carolina, Berger, Michael, Hackman, Robert C., Gough, Michael, Elliott, Carole, Jensen, Michael C., Riddell, Stanley R.

“…The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy…”
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Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD by Künkele, Annette, Johnson, Adam J, Rolczynski, Lisa S, Chang, Cindy A, Hoglund, Virginia, Kelly-Spratt, Karen S, Jensen, Michael C

“…Chimeric antigen receptor (CAR) development is biased toward selecting constructs that elicit the highest magnitude of T-cell functional outputs. Here, we show…”
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Value Maximization, Stakeholder Theory, and the Corporate Objective Function by Jensen, Michael C.

“…This paper examines the role of the corporate objective function in increasing corporate productivity, social welfare, and the accountability of managers and…”
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Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety by Vitanza, Nicholas A., Ronsley, Rebecca, Choe, Michelle, Henson, Casey, Breedt, Mandy, Barrios-Anderson, Adriel, Wein, Amy, Brown, Christopher, Beebe, Adam, Kong, Ada, Kirkey, Danielle, Lee, Brittany M., Leary, Sarah E.S., Crotty, Erin E., Hoeppner, Corrine, Holtzclaw, Susan, Wilson, Ashley L., Gustafson, Joshua A., Foster, Jessica B., Iliff, Jeffrey J., Goldstein, Hannah E., Browd, Samuel R., Lee, Amy, Ojemann, Jeffrey G., Pinto, Navin, Gust, Juliane, Gardner, Rebecca A., Jensen, Michael C., Hauptman, Jason S., Park, Julie R.

“…Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. Based on adoptive cellular therapy's clinical success…”
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Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane by James, Scott E, Greenberg, Philip D, Jensen, Michael C, Lin, Yukang, Wang, Jinjuan, Till, Brian G, Raubitschek, Andrew A, Forman, Stephen J, Press, Oliver W

“…We have targeted CD22 as a novel tumor-associated Ag for recognition by human CTL genetically modified to express chimeric TCR (cTCR) recognizing this surface…”
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Paying People to Lie: the Truth about the Budgeting Process by Jensen, Michael C.

“…This paper analyzes the counterproductive effects associated with using budgets or targets in an organisation's performance measurement and compensation…”
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Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4 + CAR T Cell Efficacy by Ali, Solin, Toews, Karin, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Grunewald, Laura, Oevermann, Lena, Deubzer, Hedwig E, Tüns, Alicia, Jensen, Michael C, Henssen, Anton G, Eggert, Angelika, Schulte, Johannes H, Schwich, Esther, Rebmann, Vera, Schramm, Alexander, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived…”
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Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies by Lu, Yingjuan J, Chu, Haiyan, Wheeler, Leroy W, Nelson, Melissa, Westrick, Elaine, Matthaei, James F, Cardle, Ian I, Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z, Jensen, Michael C, Klein, Patrick J, Low, Philip S, Leamon, Christopher P

“…Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell…”
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L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice by Hong, Hao, Brown, Christine E, Ostberg, Julie R, Priceman, Saul J, Chang, Wen-Chung, Weng, Lihong, Lin, Paul, Wakabayashi, Mark T, Jensen, Michael C, Forman, Stephen J

“…New therapeutic modalities are needed for ovarian cancer, the most lethal gynecologic malignancy. Recent clinical trials have demonstrated the impressive…”
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Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions by Lee, Sang Yun, Olsen, Philip, Lee, Dong Hoon, Kenoyer, Aimee L, Budde, Lihua E, O'Steen, Shyril, Green, Damian J, Heimfeld, Shelly, Jensen, Michael C, Riddell, Stanley R, Press, Oliver W, Till, Brian G

“…Chimeric antigen receptor (CAR)-based adoptive T-cell therapy is a highly promising treatment for lymphoid malignancies, and CD20 is an ideal target antigen…”
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pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences by Grier, Alexandra E, Burleigh, Stephen, Sahni, Jaya, Clough, Courtnee A, Cardot, Victoire, Choe, Dongwook C, Krutein, Michelle C, Rawlings, David J, Jensen, Michael C, Scharenberg, Andrew M, Jacoby, Kyle

“…Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in…”
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Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses by Bolivar-Wagers, Sara, Loschi, Michael L, Jin, Sujeong, Thangavelu, Govindarajan, Larson, Jemma H, McDonald-Hyman, Cameron S, Aguilar, Ethan G, Saha, Asim, Koehn, Brent H, Hefazi, Mehrdad, Osborn, Mark J, Jensen, Michael C, Wagner, John E, Pennell, Christopher A, Blazar, Bruce R

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and…”
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