Search Results - "JENG-PYNG SHAW"

Population Pharmacokinetics of Telavancin in Healthy Subjects and Patients with Infections by SAMARA, Emil, SHAW, Jeng-Pyng, BARRIERE, Steven L, WONG, Shekman L, WORBOYS, Philip

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Intrapulmonary Distribution of Intravenous Telavancin in Healthy Subjects and Effect of Pulmonary Surfactant on In Vitro Activities of Telavancin and Other Antibiotics by GOTFRIED, Mark H, SHAW, Jeng-Pyng, BENTON, Bret M, KRAUSE, Kevin M, GOLDBERG, Michael R, KITT, Michael M, BARRIERE, Steven L

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Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model by Hegde, Sharath S, Okusanya, Olanrewaju O, Skinner, Robert, Shaw, Jeng-Pyng, Obedencio, Glenmar, Ambrose, Paul G, Blais, Johanne, Bhavnani, Sujata M

“…TD-1792 is a novel glycopeptide-cephalosporin heterodimer investigational antibiotic that displays potent bactericidal effects against clinically relevant…”
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Mass Balance and Pharmacokinetics of [14C]Telavancin following Intravenous Administration to Healthy Male Volunteers by SHAW, Jeng-Pyng, CHEONG, Jonathan, GOLDBERG, Michael R, KITT, Michael M

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Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria by HEGDE, Sharath S, REYES, Noe, OBEDENCIO, Glen, JUDICE, J. Kevin, WIENS, Tania, VANASSE, Nicole, SKINNER, Robert, MCCULLOUGH, Julia, KANIGA, Koné, PACE, John, THOMAS, Roger, SHAW, Jeng-Pyng

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Single-Dose Pharmacokinetics and Tolerability of Telavancin in Elderly Men and Women by Goldberg, Michael R., Wong, Shekman L., Shaw, Jeng-Pyng, Kitt, Michael M., Barriere, Steven L.

“…Study Objective. To assess the safety and tolerability, and the effect of sex on the pharmacokinetic disposition, of a single intravenous dose of telavancin 10…”
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Tissue Penetration of Telavancin after Intravenous Administration in Healthy Subjects by SUN, Heather K, DUCHIN, Kenneth, NIGHTINGALE, Charles H, SHAW, Jeng-Pyng, SEROOGY, Julie, NICOLAU, David P

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Lack of Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Telavancin by Goldberg, Michael R., Wong, Shekman L., Shaw, Jeng-Pyng, Kitt, Michael M., Barriere, Steven L.

“…Study Objective. To evaluate the pharmacokinetics of the lipoglycopeptide antibiotic, telavancin, in patients with moderate hepatic impairment compared with…”
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Identification of a Putative Regulator of Early T Cell Activation Genes by Shaw, Jeng-Pyng, Utz, Paul J., Durand, David B., Toole, J. Jay, Emmel, Elizabeth Ann, Crabtree, Gerald R.

“…Molecules involved in the antigen receptor-dependent regulation of early T cell activation genes were investigated with the use of functional sequences of the…”
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Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs by CUNDY, K. C, SUEOKA, C, LYNCH, G. R, GRIFFIN, L, LEE, W. A, SHAW, J.-P

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An interspecies extrapolation of the pharmacokinetics of telavancin, a rapidly bactericidal, concentration-dependent antibiotic by Shaw, Jeng-Pyng, Jaw-Tsai, Sarah

“…Telavancin is an intravenous lipoglycopeptide antibiotic active against many Gram-positive pathogens via inhibition of bacterial cell wall synthesis and…”
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Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties by McKinnell, R. Murray, Armstrong, Scott R., Beattie, David T., Fatheree, Paul R., Long, Daniel D., Marquess, Daniel G., Shaw, Jeng-Pyng, Vickery, Ross G.

“…The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the…”
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A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma by Long, Daniel D., Frieman, Bryan, Hegde, Sharath S., Hill, Craig M., Jiang, Lan, Kintz, Samuel, Marquess, Daniel G., Purkey, Hans, Shaw, Jeng-Pyng, Steinfeld, Tod, Wilson, Michael S., Wrench, Kevin

“…Lowering of intra-ocular pressure is the primary pharmacologic approach for the treatment of glaucoma and a number of distinct mechanisms of action have been…”
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Increasing the efficiency of pharmacokinetic sample procurement, preparation and analysis by liquid chromatography/tandem mass spectrometry by Villa, Josephine S., Cass, Robert T., Karr, Dane E., Adams, Stacy M., Shaw, Jeng-Pyng, Schmidt Jr, Donald E.

“…The movement towards a 96‐well format has greatly increased productivity and throughput in bioanalytical laboratories. Improvements in automated sample…”
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Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT4 receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation by Long, Daniel D., Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A.L., Genov, Daniel, Goldblum, Adam A., Humphrey, Patrick P., Jiang, Lan, Marquess, Daniel G., Shaw, Jeng-Pyng, Smith, Jacqueline A.M., Turner, S. Derek, Vickery, Ross G.

“…Utilization of Theravance’s multivalent approach to drug discovery towards 5-HT4 receptor agonists with a focus on identification of neutral (non-charged at…”
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Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424) by Leadbetter, Michael R, Adams, Stacy M, Bazzini, Bettina, Fatheree, Paul R, Karr, Dane E, Krause, Kevin M, Lam, Bernice M T, Linsell, Martin S, Nodwell, Matthew B, Pace, John L, Quast, Kelly, Shaw, Jeng-Pyng, Soriano, Elizabeth, Trapp, Sean G, Villena, Jenny D, Wu, Terry X, Christensen, Burton G, Judice, J Kevin

“…Novel derivatives of N-decylaminoethylvancomycin (2), containing appended hydrophilic groups were synthesized and their antibacterial activity and ADME…”
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Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: Clinical compound TD-2749 by Long, Daniel D., Armstrong, Scott R., Beattie, David T., Choi, Seok-Ki, Fatheree, Paul R., Gendron, Roland A.L., Goldblum, Adam A., Humphrey, Patrick P., Marquess, Daniel G., Shaw, Jeng-Pyng, Smith, Jacqueline A.M., Derek Turner, S., Vickery, Ross G.

“…Further application of our multivalent approach to drug discovery directed to 5-HT4 receptor agonists is described. Optimization of the linker and secondary…”
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Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs by Cundy, K C, Sue, I L, Visor, G C, Marshburn, J, Nakamura, C, Lee, W A, Shaw, J P

“…The effect of formulation on oral bioavailability of the antiviral nucleotide analogue adefovir from the prodrug adefovir dipivoxil was examined in beagle…”
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Vancomycin disulfide derivatives as antibacterial agents by Mu, YongQi, Nodwell, Matthew, Pace, John L., Shaw, Jeng-Pyng, Judice, J.Kevin

“…A series of lipidated vancomycin analogues 1 bearing disulfide bonds within their lipid chains was designed and synthesized to optimize their ADME profiles…”
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Specific, high-efficiency, triple-helix-mediated cross-linking to duplex DNA by Shaw, Jeng Pyng, Milligan, John, Krawczyk, Steven H, Matteucci, Mark

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