Search Results - "JEGGO, P. A"

DNA DSB repair pathway choice: an orchestrated handover mechanism by Kakarougkas, A, Jeggo, P A

“…DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA…”
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Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells by Jeggo, P. A.

“…At least two mechanisms of DNA double-strand break (DSB) repair operate in mammalian cells. Homologous recombination, which plays a major role in lower…”
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CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair by O'Driscoll, M, Jeggo, P A

“…Several human disorders mutated in core components of the major DNA double-strand break (DSB) repair pathway, non-homologous end joining (NHEJ), have been…”
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Nonhomologous End Joining and V(D)J Recombination Require an Additional Factor by Dai, Y., Kysela, B., Hanakahi, L. A., Manolis, K., Riballo, E., Stumm, M., Harville, T. O., West, S. C., Oettinger, M. A., Jeggo, P. A.

“…DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also functions to carry out…”
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DNA Double-strand Break Repair in a Cellular Context by Shibata, A, Jeggo, P.A

“…Abstract Substantial insight into the mechanisms responding to DNA double-strand breaks has been gained from molecular, biochemical and structural approaches…”
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An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome by O’Driscoll, M., Gennery, A.R., Seidel, J., Concannon, P., Jeggo, P.A.

“…Around 15–20 hereditary disorders associated with impaired DNA damage response mechanisms have been previously described. The range of clinical features…”
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Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination by Roddam, P L, Rollinson, S, O’Driscoll, M, Jeggo, P A, Jack, A, Morgan, G J

“…The DNA double stranded break (DSB) repair mechanism, non-homologous end joining (NHEJ) represents an essential step in antigen receptor gene rearrangement…”
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DNA double-strand breaks: their cellular and clinical impact? by Jeggo, P A, Löbrich, M

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The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit by Singleton, B. K., Torres-Arzayus, M. I., Rottinghaus, S. T., Taccioli, G. E., Jeggo, P. A.

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DNA repair: PARP –  another guardian angel? by Jeggo, P.A.

“…Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These…”
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Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient by Riballo, E., Critchlow, S.E., Teo, S-H., Doherty, A.J., Priestley, A., Broughton, B., Kysela, B., Beamish, H., Plowman, N., Arlett, C.F., Lehmann, A.R., Jackson, S.P., Jeggo, P.A.

“…The major mechanism for the repair of DNA double-strand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the…”
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Molecular and biochemical characterization of xrs mutants defective in Ku80 by Singleton, B. K., Priestley, A., Steingrimsdottir, H., Gell, D., Blunt, T., Jackson, S. P., Lehmann, A. R., Jeggo, P. A.

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Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair by Woodbine, Lisa, Brunton, H, Goodarzi, A A, Shibata, A, Jeggo, P A

“…Ataxia telangiectasia (ATM) mutated and Artemis, the proteins defective in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency…”
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Accelerated Telomere Shortening and Telomere Abnormalities in Radiosensitive Cell Lines by Cabuy, E., Newton, C., Joksic, G., Woodbine, L., Koller, B., Jeggo, P. A., Slijepcevic, P.

“…Cabuy, E., Newton, C., Joksic, G., Woodbine, L., Koller, B., Jeggo, P. A. and Slijepcevic, P. Accelerated Telomere Shortening and Telomere Abnormalities in…”
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Identification of a Nonsense Mutation in the Carboxyl-Terminal Region of DNA-Dependent Protein Kinase Catalytic Subunit in the scid Mouse by Blunt, Tracy, Gell, David, Fox, Margaret, Taccioli, Guillermo E., Lehmann, Alan R., Jackson, Stephen P., Jeggo, Penny A.

“…DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku protein has double-stranded DNA…”
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The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia by Gennery, A.R., Slatter, M.A., Bhattacharya, A., Barge, D., Haigh, S., O'Driscoll, M., Coleman, R., Abinun, M., Flood, T.J., Cant, A.J., Jeggo, P.A.

“…Fanconi anemia (FA), an autosomal recessive chromosomal instability syndrome, is characterized clinically by developmental abnormalities, growth retardation,…”
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Immunodeficiency associated with DNA repair defects by Gennery, A. R., Cant, A. J., Jeggo, P. A.

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Ku80: Product of the XRCC5 Gene and Its Role in DNA Repair and V(D)J Recombination by Taccioli, Guillermo E., Gottlieb, Tanya M., Blunt, Tracy, Priestley, Anne, Demengeot, Jocelyne, Mizuta, Ryushin, Lehmann, Alan R., Alt, Frederick W., Jackson, Stephen P., Jeggo, Penny A.

“…The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells, is defective in DNA double-strand break repair and in ability to undergo V(D)J…”
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Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia by Jeggo, Penny A, Carr, Antony M, Lehmann, Alan R

“…Ataxia–telangiectasia (A–T) is an autosomal recessive human disorder that, because of its multisystem nature, is of interest to scientists and clinicians from…”
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DNA-Dependent Protein Kinase Activity is Absent in xrs-6 Cells: Implications for Site-Specific Recombination and DNA Double-Strand Break Repair by Finnie, Nicholas J., Gottlieb, Tanya M., Blunt, Tracy, Jeggo, Penny A., Jackson, Stephen P.

“…DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase composed of a catalytic subunit called p350 and a DNA binding component…”
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