Search Results - "JEGGA, Anil G"

Disease candidate gene identification and prioritization using protein interaction networks by Chen, Jing, Aronow, Bruce J, Jegga, Anil G

“…Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene…”
Get full text

Changing Trends in Computational Drug Repositioning by Yella, Jaswanth K, Yaddanapudi, Suryanarayana, Wang, Yunguan, Jegga, Anil G

“…Efforts to maximize the indications potential and revenue from drugs that are already marketed are largely motivated by what Sir James Black, a Nobel…”
Get full text

A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases by Zeighami, Yashar, Bakken, Trygve E, Nickl-Jockschat, Thomas, Peterson, Zeru, Jegga, Anil G, Miller, Jeremy A, Schulkin, Jay, Evans, Alan C, Lein, Ed S, Hawrylycz, Michael

“…Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide…”
Get full text

Improved human disease candidate gene prioritization using mouse phenotype by Chen, Jing, Xu, Huan, Aronow, Bruce J, Jegga, Anil G

“…The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors…”
Get full text

Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice by Miethke, Alexander G., Zhang, Wujuan, Simmons, Julia, Taylor, Amy E., Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G., Lages, Celine S., Nkinin, Stephenson, Keller, Bradley T., Setchell, Kenneth D.R.

“…Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive…”
Get full text

Heat Shock Improves Sca‐1+ Stem Cell Survival and Directs Ischemic Cardiomyocytes Toward a Prosurvival Phenotype Via Exosomal Transfer: A Critical Role for HSF1/miR‐34a/HSP70 Pathway by Feng, Yuliang, Huang, Wei, Meng, Wei, Jegga, Anil G., Wang, Yigang, Cai, Wenfeng, Kim, Ha Won, Pasha, Zeeshan, Wen, Zhili, Rao, Fang, Modi, Rohan M., Yu, Xiyong, Ashraf, Muhammad

“…Stem cell‐based therapy is a promising intervention for ischemic heart diseases. However, the functional integrity of stem cells is impaired in an ischemic…”
Get full text

Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease by Ghandikota, Sudhir, Sharma, Mihika, Ediga, Harshavardhana H, Madala, Satish K, Jegga, Anil G

“…Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease characterized by irreversible scarring of the lung parenchyma leading to dyspnea,…”
Get full text

Computational drug repositioning through heterogeneous network clustering by Wu, Chao, Gudivada, Ranga C, Aronow, Bruce J, Jegga, Anil G

“…Given the costly and time consuming process and high attrition rates in drug discovery and development, drug repositioning or drug repurposing is considered as…”
Get full text

Systems biology of the autophagy-lysosomal pathway by Jegga, Anil G., Schneider, Lonnie, Ouyang, Xiaosen, Zhang, Jianhua

“…The mechanisms of the control and activity of the autophagy-lysosomal protein degradation machinery are emerging as an important theme for neurodevelopment and…”
Get full text

Gene expression signature for biliary atresia and a role for interleukin‐8 in pathogenesis of experimental disease by Bessho, Kazuhiko, Mourya, Reena, Shivakumar, Pranavkumar, Walters, Stephanie, Magee, John C., Rao, Marepalli, Jegga, Anil G., Bezerra, Jorge A.

“…Biliary atresia (BA) is a progressive fibroinflammatory obstruction of extrahepatic bile ducts that presents as neonatal cholestasis. Due to the overlap in…”
Get full text

Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy by Feng, Yuliang, Cai, Liuyang, Hong, Wanzi, Zhang, Chunxiang, Tan, Ning, Wang, Mingyang, Wang, Cheng, Liu, Feng, Wang, Xiaohong, Ma, Jianyong, Gao, Chen, Kumar, Mohit, Mo, Yuanxi, Geng, Qingshan, Luo, Changjun, Lin, Yan, Chen, Haiyang, Wang, Shuang-Yin, Watson, Michael J., Jegga, Anil G., Pedersen, Roger A., Fu, Ji-dong, Wang, Zhao V., Fan, Guo-Chang, Sadayappan, Sakthivel, Wang, Yigang, Pauklin, Siim, Huang, Feng, Huang, Wei, Jiang, Lei

“…Transcriptional reconfiguration is central to heart failure, the most common cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional…”
Get full text

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis by Yombo, Dan J K, Odayar, Varshini, Gupta, Nishant, Jegga, Anil G, Madala, Satish K

“…Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function…”
Get full text

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis by Kasam, Rajesh K, Ghandikota, Sudhir, Soundararajan, Divyalakshmi, Reddy, Geereddy B, Huang, Steven K, Jegga, Anil G, Madala, Satish K

“…Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic…”
Get full text

Combination of esomeprazole and pirfenidone enhances antifibrotic efficacy in vitro and in a mouse model of TGFβ-induced lung fibrosis by Ebrahimpour, Afshin, Ahir, Manisha, Wang, Min, Jegga, Anil G., Bonnen, Mark D., Eissa, N. Tony, Montesi, Sydney B., Raghu, Ganesh, Ghebre, Yohannes T.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Currently, pirfenidone and nintedanib are the only…”
Get full text

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function by Singh, Brijendra, Jegga, Anil G, Shanmukhappa, Kumar S, Edukulla, Ramakrishna, Khurana Hershey, Gurjit H, Medvedovic, Mario, Dillon, Stacey R, Madala, Satish K

“…Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple…”
Get full text

Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death by Zhang, Xiaowei, Wang, Xiaohong, Zhu, Hongyan, Zhu, Cheng, Wang, Yigang, Pu, William T, Jegga, Anil G, Fan, Guo-Chang

“…Abstract Among the identified microRNAs (miRs) thus far, ~ 50% of mammalian miRs are clustered in the genome and transcribed as polycistronic primary…”
Get full text

Heterogeneous Distribution of Genetic Mutations in Myosin Binding Protein-C Paralogs by Desai, Darshini A., Rao, Vinay J., Jegga, Anil G., Dhandapany, Perundurai S., Sadayappan, Sakthivel

“…Myosin binding protein-C (MyBP-C) is a sarcomeric protein which regulates the force of contraction in striated muscles. Mutations in the MYBPC family of genes,…”
Get full text

Transcriptome analysis in acute gastrointestinal graft- versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease by Khandelwal, Pooja, Lounder, Dana T, Bartlett, Allison, Haberman, Yael, Jegga, Anil G, Ghandikota, Sudhir, Koo, Jane, Luebbering, Nathan, Leino, Daniel, Abdullah, Sheyar, Loveless, Michaela, Minar, Phillip, Lake, Kelly, Litts, Bridget, Karns, Rebekah, Nelson, Adam S, Denson, Lee A, Davies, Stella M

“…We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute…”
Get full text

Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis by Gajjala, Prathibha R, Kasam, Rajesh K, Soundararajan, Divyalakshmi, Sinner, Debora, Huang, Steven K, Jegga, Anil G, Madala, Satish K

“…Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with unremitting fibroblast activation including fibroblast-to-myofibroblast…”
Get full text

Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study by Yang, Lun, Wang, Kejian, Chen, Jian, Jegga, Anil G, Luo, Heng, Shi, Leming, Wan, Chunling, Guo, Xizhi, Qin, Shengying, He, Guang, Feng, Guoyin, He, Lin

“…In the era of personalized medical practice, understanding the genetic basis of patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine…”
Get full text