Search Results - "JEFFREYS, Alec J"

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations by Berg, Ingrid L, Neumann, Rita, Sarbajna, Shriparna, Odenthal-Hesse, Linda, Butler, Nicola J, Jeffreys, Alec J

“…PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated…”
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Where the crossovers are: recombination distributions in mammals by Kauppi, Liisa, Jeffreys, Alec J, Keeney, Scott

“…Until recently, recombination studies in humans and mice had identified only a few anecdotal examples of crossover hot spots. Recently, the pace of discovery…”
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Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex by Neumann, Rita, Jeffreys, Alec J, Kauppi, Liisa

“…There is considerable interest in understanding patterns of linkage disequilibrium (LD) in the human genome, to aid investigations of human evolution and…”
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Recombination regulator PRDM9 influences the instability of its own coding sequence in humans by Jeffreys, Alec J., Cotton, Victoria E., Neumann, Rita, Lam, Kwan-Wood Gabriel

“…PRDM9 plays a key role in specifying meiotic recombination hotspot locations in humans and mice via recognition of hotspot sequence motifs by a variable…”
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Transmission distortion affecting human noncrossover but not crossover recombination: a hidden source of meiotic drive by Odenthal-Hesse, Linda, Berg, Ingrid L, Veselis, Amelia, Jeffreys, Alec J, May, Celia A

“…Meiotic recombination ensures the correct segregation of homologous chromosomes during gamete formation and contributes to DNA diversity through both…”
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Intense and highly localized gene conversion activity in human meiotic crossover hot spots by Jeffreys, Alec J, May, Celia A

“…Meiotic gene conversion has an important role in allele diversification and in the homogenization of gene and other repeat DNA sequence families, sometimes…”
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Human recombination hot spots hidden in regions of strong marker association by Neumann, Rita, Panayi, Maria, Myers, Simon, Donnelly, Peter, Jeffreys, Alec J

“…The fine-scale distribution of meiotic recombination events in the human genome can be inferred from patterns of haplotype diversity in human populations but…”
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Processes of de novo duplication of human α-globin genes by Lam, Kwan-Wood G, Jeffreys, Alec J

“…Ectopic recombination between repeated but nonallelic DNA sequences plays a major role in genome evolution, creating gene families and generating copy number…”
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Processes of Copy-Number Change in Human DNA: The Dynamics of α-Globin Gene Deletion by Lam, Kwan-Wood G., Jeffreys, Alec J.

“…Ectopic recombination between locally repeated DNA sequences is of fundamental importance in the evolution of gene families, generating copy-number variation…”
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Dynamics and processes of copy number instability in human γ-globin genes by Neumann, Rita, Lawson, Victoria E, Jeffreys, Alec J

“…Copy number variation in the human genome is prevalent but relatively little is known about the dynamics of DNA rearrangement. We therefore used the duplicated…”
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Species-wide distribution of highly polymorphic minisatellite markers suggests past and present genetic exchanges among house mouse subspecies by Bonhomme, François, Rivals, Eric, Orth, Annie, Grant, Gemma R, Jeffreys, Alec J, Bois, Philippe R J

“…Four hypervariable minisatellite loci were scored on a panel of 116 individuals of various geographical origins representing a large part of the diversity…”
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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans by Jeffreys, Alec J, Berg, Ingrid L, Neumann, Rita, Lam, Kwan-Wood G, Sarbajna, Shriparna, Odenthal-Hesse, Linda, May, Celia A

“…PRDM9 has recently been identified as a likely trans regulator of meiotic recombination hot spots in humans and mice. PRDM9 contains a zinc finger array that,…”
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Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX by May, Celia A, Shone, Angela C, Kalaydjieva, Luba, Sajantila, Antti, Jeffreys, Alec J

“…Crossover between the human sex chromosomes during male meiosis is restricted to the terminal pseudoautosomal pairing regions. An obligatory exchange occurs in…”
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Meiotic recombination hot spots and human DNA diversity by Jeffreys, Alec J., Holloway, J. Kim, Kauppi, Liisa, May, Celia A., Neumann, Rita, Slingsby, M. Timothy, Webb, Adam J.

“…Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine–scale distribution…”
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The rise and fall of a human recombination hot spot by Jeffreys, Alec J, Neumann, Rita

“…Human meiotic crossovers mainly cluster into narrow hot spots that profoundly influence patterns of haplotype diversity and that may also affect genome…”
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Global haplotype diversity in the human insulin gene region by Stead, John D H, Hurles, Matthew E, Jeffreys, Alec J

“…The insulin minisatellite (INS VNTR) has been intensively analyzed due to its associations with diseases including diabetes. We have previously used patterns…”
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Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome by Huang, Yan, Hidalgo-Bravo, Alberto, Zhang, Enjie, Cotton, Victoria E, Mendez-Bermudez, Aaron, Wig, Gunjan, Medina-Calzada, Zahara, Neumann, Rita, Jeffreys, Alec J, Winney, Bruce, Wilson, James F, Clark, Duncan A, Dyer, Martin J, Royle, Nicola J

“…Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus…”
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Factors influencing recombination frequency and distribution in a human meiotic crossover hotspot by Jeffreys, Alec J., Neumann, Rita

“…Little is known about the factors that influence the frequency and distribution of meiotic recombination events within human crossover hotspots. We now…”
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Human tandem repeat sequences in forensic DNA typing by Tamaki, Keiji, Jeffreys, Alec J.

“…It has been 20 years since the first development of DNA fingerprinting and the start of forensic DNA typing. Ever since, human tandem repeat DNA sequences have…”
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Polymorphism in the activity of human crossover hotspots independent of local DNA sequence variation by Neumann, Rita, Jeffreys, Alec J.

“…Meiotic crossovers in the human genome cluster into highly localized hotspots identifiable indirectly from patterns of DNA diversity and directly by…”
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