Search Results - "JEFFREYS, A. J"

High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot by JEFFREYS, A. J, RITCHIE, A, NEUMANN, R

“…Little is known about the nature of recombination hotspots in the human genome and the relationship between crossover activity and patterns of linkage…”
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Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex by Neumann, Rita, Jeffreys, Alec J, Kauppi, Liisa

“…There is considerable interest in understanding patterns of linkage disequilibrium (LD) in the human genome, to aid investigations of human evolution and…”
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Minisatellite instability and germline mutation by Bois, P, Jeffreys, A J

“…Tandem-repeat DNA actively turns over in the genome by a variety of poorly understood dynamic mechanisms. Minisatellites, a class of tandem repeats, have been…”
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Meiotic Recombination and Flanking Marker Exchange at the Highly Unstable Human Minisatellite CEB1 ( D2S90) by Buard, Jérôme, Shone, Angela C., Jeffreys, Alec J.

“…Unequal crossover has long been suspected to play a role in the germline-specific instability of tandem-repeat DNA, but little information exists on the…”
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Complex gene conversion events in germline mutation at human minisatellites by Jeffreys, Alec J, Tamaki, Keiji, MacLeod, Annette, Monckton, Darren G, Neil, David L, Armour, John A.L

“…Mutation at the human minisatellites MS32, MS205 and MS31A has been investigated by characterizing mutant alleles in pedigrees and in the case of MS32 by…”
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Uniparental paternal disomy in Angelman's syndrome by Malcolm, S, Clayton-Smith, J, Nichols, M, Robb, S, Webb, T, Armour, J A, Jeffreys, A J, Pembrey, M E

“…Angelman's syndrome and Prader-Willi syndrome are both causes of mental retardation with recognisable, but quite different, clinical phenotypes. Both are…”
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Isolation of human simple repeat loci by hybridization selection by Armour, J A, Neumann, R, Gobert, S, Jeffreys, A J

“…We have isolated short tandem repeat arrays from the human genome, using a rapid method involving filter hybridization to enrich for tri- or tetranucleotide…”
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Individual-specific 'fingerprints' of human DNA by Jeffreys, A. J, Wilson, V, Thein, S. L

“…Simple tandem-repetitive regions of DNA (or 'minisatellites') which are dispersed in the human genome frequently show substantial length polymorphism arising…”
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Extremely Complex Repeat Shuffling during Germline Mutation at Human Minisatellite B6.7 by Tamaki, Keiji, May, Celia A., Dubrova, Yuri E., Jeffreys, Alec J.

“…Human minisatellite B6.7 is a highly variable locus showing extensive heterozygosity with alleles ranging from six to >500 repeat units. Paternal and maternal…”
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Chromosome 5 allele loss in human colorectal carcinomas by Solomon, E, Voss, R, Hall, V, Bodmer, W. F, Jass, J. R, Jeffreys, A. J, Lucibello, F. C, Patel, I, Rider, S. H

“…That the sporadic and inherited forms of a particular cancer could both result from mutations in the same gene was first proposed by Knudson. He further…”
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Somatic mutation processes at a human minisatellite by JEFFREYS, A. J, NEUMANN, R

“…Germline instability at human minisatellites frequently involves complex inter-allelic transfers of repeat units usually restricted to one end of the repeat…”
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Amplification of human minisatellites by the polymerase chain reaction: towards DNA fingerprinting of single cells by JEFFREYS, A. J, WILSON, V, NEUMANN, R, KEYTE, J

“…Hypervariable minisatellites can be amplified from human DNA by the polymerase chain reaction, using primers from DNA flanking the minisatellite to amplify the…”
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Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination by BADGE, R. M, YARDLEY, J, JEFFREYS, A. J, ARMOUR, J. A. L

“…Segregation analysis of CEPH and other pedigrees yielded six paternal crossover breakpoints in the approximately 85 kb interval between the minisatellite loci…”
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Minisatellite repeat coding as a digital approach to DNA typing by Jeffreys, Alec J, MacLeod, Annette, Tamaki, Keiji, Neil, David L, Monckton, Darren G

“…Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple…”
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Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA by Jeffreys, Alec J, Royle, Nicola J, Wilson, Victoria, Wong, Zilla

“…Tandem-repetitive minisatellite regions in vertebrate DNA frequently show substantial allelic variation in the number of repeat units. This variation is…”
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Allele diversity and germline mutation at the insulin minisatellite by STEAD, J. D. H, JEFFREYS, A. J

“…Previous analysis of germline mutation at highly unstable GC-rich minisatellites with continuous allele size distributions revealed similar meiotic…”
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Minisatellite diversity supports a recent African origin for modern humans by Armour, John A.L, Anttinen, Tiiu, May, Celia A, Vega, Emilce E, Sajantila, Antti, Kidd, Judith R, Kidd, Kenneth K, Bertranpetit, Jaume, Pääbo, Svante, Jeffreys, Alec J

“…In a study of human diversity at a highly variable locus, we have mapped the internal structures of tandem-repetitive alleles from different populations at the…”
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Repeat instability at human minisatellites arising from meiotic recombination by Jeffreys, Alec J., Neil, David L., Neumann, Rita

“…Little is known about the role of meiotic recombination processes such as unequal crossover in driving instability at tandem repeat DNA. Methods have therefore…”
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DNA fingerprints of dogs and cats by Jeffreys, A J, Morton, D B

“…Human minisatellite probes consisting of tandem repeats of the 'core' sequence, a putative recombination signal in human DNA, cross-hybridize to multiple…”
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Hypervariable 'minisatellite' regions in human DNA by Jeffreys, Alec J, Wilson, Victoria, Thein, Swee Lay

“…The human genome contains many dispersed tandem-repetitive 'minisatellite' regions detected via a shared 10-15-base pair 'core' sequence similar to the…”
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