Search Results - "JAYAKUMAR, Calpurnia"

Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization by Ranganathan, Punithavathi Vilapakkam, Jayakumar, Calpurnia, Ramesh, Ganesan

“…Improper macrophage activation is pathogenically linked to various metabolic, inflammatory, and immune disorders. Therefore, regulatory proteins controlling…”
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CXCR2 knockout mice are protected against DSS-colitis-induced acute kidney injury and inflammation by Ranganathan, Punithavathi, Jayakumar, Calpurnia, Manicassamy, Santhakumar, Ramesh, Ganesan

“…Organ cross talk exists in many diseases of the human and animal models of human diseases. A recent study demonstrated that inflammatory mediators can cause…”
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Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production by Ranganathan, Punithavathi V, Jayakumar, Calpurnia, Mohamed, Riyaz, Dong, Zheng, Ramesh, Ganesan

“…Netrin-1 regulates inflammation but the mechanism by which this occurs is unknown. Here we explore the role of netrin-1 in regulating the production of the…”
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Proximal tubule-specific overexpression of netrin-1 suppresses acute kidney injury-induced interstitial fibrosis and glomerulosclerosis through suppression of IL-6/STAT3 signaling by Ranganathan, Punithavathi, Jayakumar, Calpurnia, Ramesh, Ganesan

“…Acute kidney injury-induced organ fibrosis is recognized as a major risk factor for the development of chronic kidney disease, which remains one of the leading…”
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MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death by Tang, Yaoping, Wang, Yongchao, Park, Kyoung-Mi, Hu, Qiuping, Teoh, Jian-Peng, Broskova, Zuzana, Ranganathan, Punithavathi, Jayakumar, Calpurnia, Li, Jie, Su, Huabo, Tang, Yaoliang, Ramesh, Ganesan, Kim, Il-Man

“…Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs). For example, miR-150 is down-regulated in patients with acute…”
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Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity by Ranganathan, Punithavathi, Hamad, Rania, Mohamed, Riyaz, Jayakumar, Calpurnia, Muthusamy, Thangaraju, Ramesh, Ganesan

“…Cisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors. Currently, there are no therapies available to…”
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Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6 by Mohamed, Riyaz, Jayakumar, Calpurnia, Ramesh, Ganesan

“…Diabetic nephropathy is currently the most common cause of end-stage renal disease in the western world. Exacerbated inflammation of the kidney is known to…”
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Kidney Proximal Tubular Epithelial-Specific Overexpression of Netrin-1 Suppresses Inflammation and Albuminuria through Suppression of COX-2-Mediated PGE2 Production in Streptozotocin-Induced Diabetic Mice by Mohamed, Riyaz, Jayakumar, Calpurnia, Ranganathan, Punithavathi V, Ganapathy, Vadivel, Ramesh, Ganesan

“…Inflammation plays a key role in the development and progression of diabetic kidney disease; however, the role of the anti-inflammatory molecule netrin-1 in…”
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Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury by Ranganathan, Punithavathi, Jayakumar, Calpurnia, Mohamed, Riyaz, Weintraub, Neal L, Ramesh, Ganesan

“…Recent studies show that guidance molecules that are known to regulate cell migration during development may also play an important role in adult…”
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MicroRNA-150 deletion in mice protects kidney from myocardial infarction-induced acute kidney injury by Ranganathan, Punithavathi, Jayakumar, Calpurnia, Tang, Yaoping, Park, Kyoung-mi, Teoh, Jian-peng, Su, Huabo, Li, Jie, Kim, Il-man, Ramesh, Ganesan

“…Despite greater understanding of acute kidney injury (AKI) in animal models, many of the preclinical studies are not translatable. Most of the data were…”
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Netrin-1 regulates colon-kidney cross talk through suppression of IL-6 function in a mouse model of DSS-colitis by Ranganathan, Punithavathi, Jayakumar, Calpurnia, Santhakumar, Manicassamy, Ramesh, Ganesan

“…Organ cross talk is increasingly appreciated in human disease, and inflammatory mediators are shown to mediate distant organ injury in many disease models…”
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Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease by Ramesh, Ganesan, Jayakumar, Calpurnia, Mohamed, Riyaz, Ranganathan, Punithavathi

“…Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit. Despite improved understanding, there are no effective therapies…”
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Intracellular kinases mediate increased translation and secretion of netrin-1 from renal tubular epithelial cells by Jayakumar, Calpurnia, Mohamed, Riyaz, Ranganathan, Punithavathi Vilapakkam, Ramesh, Ganesan

“…Netrin-1 is a laminin-related secreted protein, is highly induced after tissue injury, and may serve as a marker of injury. However, the regulation of netrin-1…”
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Semaphorin 3A is a new early diagnostic biomarker of experimental and pediatric acute kidney injury by Jayakumar, Calpurnia, Ranganathan, Punithavathi, Devarajan, Prasad, Krawczeski, Catherine D, Looney, Stephen, Ramesh, Ganesan

“…Semaphorin 3A is a secreted protein that regulates cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor…”
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Plasma netrin-1 is a diagnostic biomarker of human cancers by Ramesh, Ganesan, Berg, Arthur, Jayakumar, Calpurnia

“…Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives: To determine whether plasma netrin-1…”
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UNC5B Receptor Deletion Exacerbates Tissue Injury in Response to AKI by RANGANATHAN, Punithavathi, JAYAKUMAR, Calpurnia, NAVANKASATTUSAS, Sutip, LI, Dean Y, KIM, Il-Man, RAMESH, Ganesan

“…Netrin-1 regulates cell survival and apoptosis by activation of its receptors, including UNC5B. However, the in vivo role of UNC5B in cell survival during…”
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Repulsive guidance cue semaphorin 3A in urine predicts the progression of acute kidney injury in adult patients from a mixed intensive care unit by Doi, Kent, Noiri, Eisei, Nangaku, Masaomi, Yahagi, Naoki, Jayakumar, Calpurnia, Ramesh, Ganesan

“…Predicting the development of acute kidney injury (AKI) in the critical care setting is challenging. Although several biomarkers showed somewhat satisfactory…”
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Netrin-1 and semaphorin 3A predict the development of acute kidney injury in liver transplant patients by Lewandowska, Lidia, Matuszkiewicz-Rowińska, Joanna, Jayakumar, Calpurnia, Oldakowska-Jedynak, Urszula, Looney, Stephen, Galas, Michalina, Dutkiewicz, Małgorzata, Krawczyk, Marek, Ramesh, Ganesan

“…Acute kidney injury (AKI) is a serious complication after liver transplantation. Currently there are no validated biomarkers available for early diagnosis of…”
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Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis by Mohamed, Riyaz, Jayakumar, Calpurnia, Chen, Feng, Fulton, David, Stepp, David, Gansevoort, Ron T, Ramesh, Ganesan

“…Diabetes is the leading cause of kidney failure, accounting for >45% of new cases of dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis,…”
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Urinary semaphorin 3A correlates with diabetic proteinuria and mediates diabetic nephropathy and associated inflammation in mice by Mohamed, Riyaz, Ranganathan, Punithavathi, Jayakumar, Calpurnia, Nauta, Ferdau L., Gansevoort, Ron T., Weintraub, Neal L., Brands, Michael, Ramesh, Ganesan

“…Semaphorin 3A (sema3A) was recently identified as an early diagnostic biomarker of acute kidney injury. However, its role as a biomarker and/or mediator of…”
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