Search Results - "JAVITT, D. C"

Glutamate as a therapeutic target in psychiatric disorders by JAVITT, D. C

“…Glutamate is the primary excitatory neurotransmitter in the mammalian brain. Glutamatergic neurotransmission may be modulated at multiple levels, only a…”
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Neural mechanisms of mismatch negativity dysfunction in schizophrenia by Lee, M, Sehatpour, P, Hoptman, M J, Lakatos, P, Dias, E C, Kantrowitz, J T, Martinez, A M, Javitt, D C

“…Schizophrenia is associated with cognitive deficits that reflect impaired cortical information processing. Mismatch negativity (MMN) indexes pre-attentive…”
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Emotion recognition deficits as predictors of transition in individuals at clinical high risk for schizophrenia: a neurodevelopmental perspective by Corcoran, C M, Keilp, J G, Kayser, J, Klim, C, Butler, P D, Bruder, G E, Gur, R C, Javitt, D C

“…Schizophrenia is characterized by profound and disabling deficits in the ability to recognize emotion in facial expression and tone of voice. Although these…”
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Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression by Moreno-Ortega, M., Prudic, J., Rowny, S., Patel, G. H., Kangarlu, A., Lee, S., Grinband, J., Palomo, T., Perera, T., Glasser, M. F., Javitt, D. C.

“…There is increasing focus on use of resting-state functional connectivity (RSFC) analyses to subtype depression and to predict treatment response. To date,…”
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Inhibition of System A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action by JAVITT, D. C, DUNCAN, L, BALLA, A, SERSHEN, H

“…Clozapine is an atypical antipsychotic with particular efficacy in schizophrenia, possibly related to potentiation of brain N-methyl-D-aspartate receptor…”
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Amusia and protolanguage impairments in schizophrenia by Kantrowitz, J T, Scaramello, N, Jakubovitz, A, Lehrfeld, J M, Laukka, P, Elfenbein, H A, Silipo, G, Javitt, D C

“…Both language and music are thought to have evolved from a musical protolanguage that communicated social information, including emotion. Individuals with…”
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The 5% difference: early sensory processing predicts sarcasm perception in schizophrenia and schizo-affective disorder by Kantrowitz, J T, Hoptman, M J, Leitman, D I, Silipo, G, Javitt, D C

“…Intact sarcasm perception is a crucial component of social cognition and mentalizing (the ability to understand the mental state of oneself and others). In…”
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Objects are highlighted by spatial attention by Martínez, A, Teder-Sälejärvi, W, Vazquez, M, Molholm, S, Foxe, J J, Javitt, D C, Di Russo, F, Worden, M S, Hillyard, S A

“…Selective attention may be focused upon a region of interest within the visual surroundings, thereby improving the perceptual quality of stimuli at that…”
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Expectancy-related modulations of neural oscillations in continuous performance tasks by Bickel, S., Dias, E.C., Epstein, M.L., Javitt, D.C.

“…Analysis of neural oscillations in the electroencephalogram (EEG) during cognitive tasks provides valuable information about underlying neuronal processing not…”
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Schizophrenia, culture and neuropsychology: sensory deficits, language impairments and social functioning in Chinese-speaking schizophrenia patients by Yang, L, Chen, S, Chen, C-M, Khan, F, Forchelli, G, Javitt, D C

“…While 20% of schizophrenia patients worldwide speak tonal languages (e.g. Mandarin), studies are limited to Western-language patients. Western-language…”
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Sensory Processing in Schizophrenia: Neither Simple nor Intact by Javitt, Daniel C.

“…This special issue focuses on the theme of sensory processing dysfunction in schizophrenia. For more than 50 years, from approximately the time of Bleuler…”
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Schizophrenia Patients Show Task Switching Deficits Consistent With N-Methyl-D-Aspartate System Dysfunction But Not Global Executive Deficits: Implications for Pathophysiology of Executive Dysfunction in Schizophrenia by WYLIE, Glenn R, CLARK, E. A, BUTLER, P. D, JAVITT, D. C

“…Schizophrenia is associated with cognitive processing deficits, including deficits in executive processing, that represent a core component of the disorder. In…”
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Recent advances in the phencyclidine model of schizophrenia by Javitt, D C, Zukin, S R

“…Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis,…”
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A topography of executive functions and their interactions revealed by functional magnetic resonance imaging by Fassbender, C., Murphy, K., Foxe, J.J., Wylie, G.R., Javitt, D.C., Robertson, I.H., Garavan, H.

“…We used fMRI to study the brain processes involved in the executive control of behavior. The Sustained Attention to Response Task (SART), which allows…”
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Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia by Javitt, Daniel C, Zukin, Stephen R, Heresco-Levy, Uriel, Umbricht, Daniel

“…Over the last 20 years, glutamatergic models of schizophrenia have become increasingly accepted as etiopathological models of schizophrenia, based on the…”
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Jumping the Gun: Is Effective Preparation Contingent upon Anticipatory Activation in Task-relevant Neural Circuitry? by Wylie, G.R., Javitt, D.C., Foxe, J.J.

“…Subjects switched between tasks that rely on separable ‘low-level’ neural circuits, a motion and a color task. Using functional magnetic resonance imaging, we…”
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Task switching: a high-density electrical mapping study by Wylie, G.R, Javitt, D.C, Foxe, J.J

“…Flexibly switching between tasks is one of the paradigmatic functions of so-called “executive control” processes. Neuroimaging studies have implicated both…”
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Dysfunction of Early-Stage Visual Processing in Schizophrenia by Butler, Pamela D., Schechter, Isaac, Zemon, Vance, Schwartz, Stephen G., Greenstein, Vivienne C., Gordon, James, Schroeder, Charles E., Javitt, Daniel C.

“…OBJECTIVE: Schizophrenia is associated with deficits in higher-order processing of visual information. This study evaluated the integrity of early visual…”
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Role of Cortical N-methyl-D-aspartate Receptors in Auditory Sensory Memory and Mismatch Negativity Generation: Implications for Schizophrenia by Javitt, Daniel C., Steinschneider, Mitchell, Schroeder, Charles E., Arezzo, Joseph C.

“…Working memory refers to the ability of the brain to store and manipulate information over brief time periods, ranging from seconds to minutes. As opposed to…”
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Amelioration of negative symptoms in schizophrenia by glycine by Javitt, D C, Zylberman, I, Zukin, S R, Heresco-Levy, U, Lindenmayer, J P

“…Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled…”
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