Search Results - "JAT, P. S"

Activation of nuclear factor-kappa B signalling promotes cellular senescence by Rovillain, E, Mansfield, L, Caetano, C, Alvarez-Fernandez, M, Caballero, O L, Medema, R H, Hummerich, H, Jat, P S

“…Cellular senescence is a programme of irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in…”
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Transcriptional networks and cellular senescence in human mammary fibroblasts by Hardy, K, Mansfield, L, Mackay, A, Benvenuti, S, Ismail, S, Arora, P, O'Hare, M J, Jat, P S

“…Senescence, the molecular program that limits the finite proliferative potential of a cell, acts as an important barrier to protect the body from cancer…”
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Establishment of Conditionally Immortalized Epithelial Cell Lines from both Colon and Small Intestine of Adult H-2Kb-tsA58 Transgenic Mice by Whitehead, R. H., VanEeden, P. E., Noble, M. D., Ataliotis, P., Jat, P. S.

“…Intestinal mucosal cells have proved difficult to culture in vitro. Many attempts have been made to develop long-term cultures of these cells either by direct…”
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Direct Derivation of Conditionally Immortal Cell Lines from an H-2Kb- tsA58 Transgenic Mouse by Jat, Parmjit S., Noble, Mark D., Ataliotis, Paris, Tanaka, Yujiro, Yannoutsos, Nikos, Larsen, Lena, Kioussis, Dimitris

“…Studies on cell lines have greatly improved our understanding of many important biological questions. Generation of cell lines is facilitated by the…”
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Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus by Sinden, J.D, Rashid-Doubell, F, Kershaw, T.R, Nelson, A, Chadwick, A, Jat, P.S, Noble, M.D, Hodges, H, Gray, J.A

“…Transient global cerebral ischaemia in rats causes relatively circumscribed and specific damage to the CA1 pyramidal cells of the dorsal hippocampus, [18]along…”
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Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature by JAT, P. S, SHARP, P. A

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Myogenic Cell Lines Derived from Transgenic Mice Carrying a Thermolabile T Antigen: A Model System for the Derivation of Tissue-Specific and Mutation-Specific Cell Lines by Morgan, J.E., Beauchamp, J.R., Pagel, C.N., Peckham, M., Ataliotis, P., Jat, P.S., Noble, M.D., Farmer, K., Partridge, T.A.

“…Skeletal myoblasts cloned from limb muscles of H-2Kb-tsA58 transgenic mice remained proliferative through at least 80 generations under conditions permissive…”
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Roles of Hepatocyte Growth Factor/Scatter Factor and the Met Receptor in the Early Development of the Metanephros by Woolf, Adrian S., Kolatsi-Joannou, Maria, Hardman, Patricia, Andermarcher, Elisabetta, Moorby, Catriona, Fine, Leon G., Jat, Parmjit S., Noble, Mark D., Gherardi, Ermanno

“…Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several…”
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Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia by AHUJA, H. G, JAT, P. S, FOTI, A, BAR-ELI, M, CLINE, M. J

“…The retinoblastoma-susceptibility (Rb) gene is an antioncogene that is frequently altered in retinoblastomas, sarcomas, and some epithelial tumors. We examined…”
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Immortalization of precursor cells from the mammalian CNS by Frederiksen, K, Jat, P S, Valtz, N, Levy, D, McKay, R

“…Recent studies show that the nervous system contains many molecularly distinct cell types. Clonal cell marking experiments demonstrate that different cell…”
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Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens by JAT, P. S, CEPKO, C. L, MULLIGAN, R. C, SHARP, P. A

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Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts by JAT, P. S, SHARP, P. A

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Immortalization of epithelial cells by Hopfer, U, Jacobberger, J W, Gruenert, D C, Eckert, R L, Jat, P S, Whitsett, J A

“…The methodologies for isolating cell lines have become very powerful, particularly in terms of retaining differentiated features of the parent cells. Cell…”
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A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen by Eibl, RH, Kleihues, P, Jat, PS, Wiestler, OD

“…Using retrovirus-mediated transfer of the SV40 virus large T antigen into neural transplants, we have observed a high incidence of primitive neuroectodermal…”
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Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer by WEINBERGER, J, JAT, P. S, SHARP, P. A

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Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen by POWELL, A. J, DARMON, A. J, GONOS, E. S, LAM, E. W.-F, PEDEN, K. W. C, JAT, P. S

“…We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo…”
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The Biological Clock that Measures the Mitotic Life-Span of Mouse Embryo Fibroblasts Continues to Function in the Presence of Simian Virus 40 Large Tumor Antigen by Ikram, Zebbie, Norton, Trisha, Jat, Parmjit S.

“…Normal mammalian fibroblasts cultured in vitro undergo a limited number of divisions before entering a senescent phase in which they can be maintained for long…”
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cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells by MACKAY, Alan, JONES, Chris, REIS, Luiz F. L, LAKHANI, Sunil R, O'HARE, Michael J, DEXTER, Tim, SILVA, Ricardo L. A, BULMER, Karen, JONES, Allison, SIMPSON, Peter, HARRIS, Robert A, JAT, Parmjit S, MUNRO NEVILLE, A

“…To investigate changes in gene expression associated with ERBB2, expression profiling of immortalized human mammary luminal epithelial cells and variants…”
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Conditional Immortalization of Freshly Isolated Human Mammary Fibroblasts and Endothelial Cells by O'Hare, Michael J., Bond, Jacquelyn, Clarke, Catherine, Takeuchi, Yasuhiro, Atherton, Amanda J., Berry, Catherine, Moody, John, Andrew R. J. Silver, Davies, Derek C., Alsop, Amber E., Neville, A. Munro, Jat, Parmjit S.

“…Reports differ as to whether reconstitution of telomerase activity alone is sufficient for immortalization of different types of human somatic cells or whether…”
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Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer by Jia, Min, Souchelnytskyi, Nazariy, Hellman, Ulf, O'Hare, Michael, Jat, Parmjit S., Souchelnytskyi, Serhiy

“…Purpose: Immortalization is one of the first changes in cells undergoing carcinogenic transformation. Proteome profiling of the immortalization–senescence…”
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