Search Results - "JARES, Pedro"

Chronic lymphocytic leukemia and mantle cell lymphoma: crossroads of genetic and microenvironment interactions by Puente, Xose S., Jares, Pedro, Campo, Elias

“…Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined entities that diverge in their basic pathogenic mechanisms and clinical…”
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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics by Campo, Elias, Jares, Pedro, Colomer, Dolors

“…Mantle cell lymphoma (MCL) is a well-defined lymphoid malignancy characterized by a rapid clinical evolution and poor response to current therapeutic…”
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Advances in the understanding of mantle cell lymphoma by Jares, Pedro, Campo, Elías

“…Summary Mantle cell lymphoma (MCL) is a well‐defined lymphoid neoplasm characterized by a proliferation of mature B lymphocytes expressing CD5 that may show a…”
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Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia by Nadeu, Ferran, Delgado, Julio, Royo, Cristina, Baumann, Tycho, Stankovic, Tatjana, Pinyol, Magda, Jares, Pedro, Navarro, Alba, Martín-García, David, Beà, Sílvia, Salaverria, Itziar, Oldreive, Ceri, Aymerich, Marta, Suárez-Cisneros, Helena, Rozman, Maria, Villamor, Neus, Colomer, Dolors, López-Guillermo, Armando, González, Marcos, Alcoceba, Miguel, Terol, Maria José, Colado, Enrique, Puente, Xose S., López-Otín, Carlos, Enjuanes, Anna, Campo, Elías

“…Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic leukemia (CLL). The acquisition and selection of genomic aberrations may…”
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SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma by Palomero, Jara, Vegliante, Maria Carmela, Rodríguez, Marta Leonor, Eguileor, Álvaro, Castellano, Giancarlo, Planas-Rigol, Ester, Jares, Pedro, Ribera-Cortada, Inmaculada, Cid, Maria C., Campo, Elias, Amador, Virginia

“…SOX11 is overexpressed in several solid tumors and in the vast majority of aggressive mantle cell lymphomas (MCLs). We have recently proven that SOX11…”
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Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma by FERNANDEZ, Verònica, SALAMERO, Olga, HERNANDEZ, Luis, AGOSTINELLI, Claudio, SARGENT, Rachel L, ROZMAN, Maria, AYMERICH, Marta, COLOMER, Dolors, VILLAMOR, Neus, SWERDLOW, Steven H, PILERI, Stefano A, BOSCH, Francesc, ESPINET, Blanca, PIRIS, Miguel A, MONTSERRAT, Emili, OTT, German, ROSENWALD, Andreas, LOPEZ-GUILLERMO, Armando, JARES, Pedro, SERRANO, Sergi, CAMPO, Elias, SOLE, Francesc, ROYO, Cristina, NAVARRO, Alba, CAMACHO, Francisca, BEA, Silvia, HARTMANN, Elena, AMADOR, Virginia

“…Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate…”
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Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer by Codony-Servat, Jordi, Cuatrecasas, Miriam, Asensio, Elena, Montironi, Carla, Martínez-Cardús, Anna, Marín-Aguilera, Mercedes, Horndler, Carlos, Martínez-Balibrea, Eva, Rubini, Michele, Jares, Pedro, Reig, Oscar, Victoria, Iván, Gaba, Lydia, Martín-Richard, Marta, Alonso, Vicente, Escudero, Pilar, Fernández-Martos, Carlos, Feliu, Jaime, Méndez, Jose Carlos, Méndez, Miguel, Gallego, Javier, Salud, Antonieta, Rojo, Federico, Castells, Antoni, Prat, Aleix, Rosell, Rafael, García-Albéniz, Xabier, Camps, Jordi, Maurel, Joan

“…Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and…”
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SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma by Vegliante, Maria Carmela, Palomero, Jara, Pérez-Galán, Patricia, Roué, Gaël, Castellano, Giancarlo, Navarro, Alba, Clot, Guillem, Moros, Alexandra, Suárez-Cisneros, Helena, Beà, Sílvia, Hernández, Luis, Enjuanes, Anna, Jares, Pedro, Villamor, Neus, Colomer, Dolors, Martín-Subero, José Ignacio, Campo, Elias, Amador, Virginia

“…Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose pathogenesis is not fully understood. The neural transcription factor SOX11…”
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Comparison of the Idylla™ MSI assay with the Promega™ MSI Analysis System and immunohistochemistry on formalin-fixed paraffin-embedded tissue of endometrial carcinoma: results from an international, multicenter study by Gatius, Sonia, Velasco, Ana, Varela, Mar, Cuatrecasas, Miriam, Jares, Pedro, Setaffy, Lisa, Bonhomme, Benjamin, Santon, Almudena, Lindemann, Kristina, Croce, Sabrina, Davidson, Ben, Lax, Sigurd, Palacios, Jose, Matias-Guiu, Xavier

“…Determination of microsatellite instability (MSI) and mismatch repair deficiency (MMRD), respectively, in endometrial carcinomas (ECs) is important for…”
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Development and validation of the new HER2DX assay for predicting pathological response and survival outcome in early-stage HER2-positive breast cancer by Prat, Aleix, Guarneri, Valentina, Pascual, Tomás, Brasó-Maristany, Fara, Sanfeliu, Esther, Paré, Laia, Schettini, Francesco, Martínez, Débora, Jares, Pedro, Griguolo, Gaia, Dieci, Maria Vittoria, Cortés, Javier, Llombart-Cussac, Antonio, Conte, Benedetta, Marín-Aguilera, Mercedes, Chic, Nuria, Puig-Butillé, Joan Anton, Martínez, Antonio, Galván, Patricia, Tsai, Yi-Hsuan, González-Farré, Blanca, Mira, Aurea, Vivancos, Ana, Villagrasa, Patricia, Parker, Joel S., Conte, Pierfranco, Perou, Charles M.

“…Both clinical and genomic data independently predict survival and treatment response in early-stage HER2-positive breast cancer. Here we present the…”
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Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms by Albero, Robert, Enjuanes, Anna, Demajo, Santiago, Castellano, Giancarlo, Pinyol, Magda, García, Noelia, Capdevila, Cristina, Clot, Guillem, Suárez-Cisneros, Helena, Shimada, Mariko, Karube, Kennosuke, López-Guerra, Mónica, Colomer, Dolors, Beà, Sílvia, Martin-Subero, José Ignacio, Campo, Elías, Jares, Pedro

“…Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is…”
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MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms by Fernández-Garnacho, Elena María, Nadeu, Ferran, Martín, Silvia, Mozas, Pablo, Rivero, Andrea, Delgado, Julio, Giné, Eva, López-Guillermo, Armando, Duran-Ferrer, Martí, Salaverria, Itziar, López, Cristina, Beà, Sílvia, Demajo, Santiago, Jares, Pedro, Puente, Xose S., Martín-Subero, José Ignacio, Campo, Elías, Hernández, Lluís

“…MALAT1 long non-coding RNA has oncogenic roles but has been poorly studied in indolent B-cell neoplasms. Here, MALAT1 expression was analyzed using RNA-seq,…”
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Molecular Landscape of Vulvar Squamous Cell Carcinoma by Carreras-Dieguez, Núria, Guerrero, José, Rodrigo-Calvo, Maria Teresa, Ribera-Cortada, Inmaculada, Trias, Isabel, Jares, Pedro, López del Campo, Ricardo, Saco, Adela, Munmany, Meritxell, Marimon, Lorena, Ferrando, Melania, Vega, Naiara, del Pino, Marta, Torné, Aureli, Ordi, Jaume, Rakislova, Natalia

“…Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with dual pathogenesis, Human papillomavirus (HPV)-associated and HPV-independent, with a poorly…”
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Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling by Beà, Sílvia, Salaverria, Itziar, Armengol, Lluís, Pinyol, Magda, Fernández, Verónica, Hartmann, Elena M., Jares, Pedro, Amador, Virginia, Hernández, Luís, Navarro, Alba, Ott, German, Rosenwald, Andreas, Estivill, Xavier, Campo, Elias

“…Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. However,…”
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Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review by Ribera-Cortada, Inmaculada, Guerrero-Pineda, José, Trias, Isabel, Veloza, Luis, Garcia, Adriana, Marimon, Lorena, Diaz-Mercedes, Sherley, Alamo, José Ramon, Rodrigo-Calvo, Maria Teresa, Vega, Naiara, López Del Campo, Ricardo, Parra-Medina, Rafael, Ajami, Tarek, Martínez, Antonio, Reig, Oscar, Ribal, Maria J, Corral-Molina, Juan Manuel, Jares, Pedro, Ordi, Jaume, Rakislova, Natalia

“…Penile squamous cell carcinoma (PSCC) is a rare but aggressive neoplasm with dual pathogenesis (human papillomavirus (HPV)-associated and HPV-independent). The…”
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Intrinsic subtypes and therapeutic decision-making in hormone receptor-positive/HER2-negative metastatic breast cancer with visceral crisis: A case report by Schettini, Francesco, Seguí, Elia, Conte, Benedetta, Sanfeliu, Esther, Gonzalez-Farre, Blanca, Jares, Pedro, Vidal-Sicart, Sergi, Ganau, Sergi, Cebrecos, Isaac, Brasó-Maristany, Fara, Muñoz, Montserrat, Prat, Aleix, Vidal, Maria

“…CDK4/6 inhibitors (CDKi), namely, palbociclib, ribociclib, and abemaciclib, combined with either an aromatase inhibitor (AI) or fulvestrant are the standard…”
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The Expression of the Endoplasmic Reticulum Stress Sensor BiP/GRP78 Predicts Response to Chemotherapy and Determines the Efficacy of Proteasome Inhibitors in Diffuse Large B-Cell Lymphoma by Mozos, Ana, Roué, Gaël, López-Guillermo, Armando, Jares, Pedro, Campo, Elias, Colomer, Dolors, Martinez, Antonio

“…Activation of the endoplasmic reticulum (ER) stress pathway is associated with poor response to doxorubicin-containing regimens, such as rituximab,…”
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EBUS-TBNA Cytological Samples for Comprehensive Molecular Testing in Non-Small Cell Lung Cancer by Martin-Deleon, Roberto, Teixido, Cristina, Lucena, Carmen Mª, Martinez, Daniel, Fontana, Ainhoa, Reyes, Roxana, García, Mireia, Viñolas, Nuria, Vollmer, Ivan, Sanchez, Marcelo, Jares, Pedro, Pérez, Francisco Manuel, Vega, Naiara, Marin, Elba, Marrades, Ramón Mª, Agustí, Carlos, Reguart, Noemi

“…Clinical guidelines promote the identification of several targetable biomarkers to drive treatment decisions in advanced non-small cell lung cancer (NSCLC),…”
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Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling by Hartmann, Elena M., Campo, Elias, Wright, George, Lenz, Georg, Salaverria, Itziar, Jares, Pedro, Xiao, Wenming, Braziel, Rita M., Rimsza, Lisa M., Chan, Wing-Chung, Weisenburger, Dennis D., Delabie, Jan, Jaffe, Elaine S., Gascoyne, Randy D., Dave, Sandeep S., Mueller-Hermelink, Hans-Konrad, Staudt, Louis M., Ott, German, Beà, Sílvia, Rosenwald, Andreas

“…The genome of mantle cell lymphoma (MCL) is, in addition to the translocation t(11;14), characterized by a high number of secondary chromosomal gains and…”
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Improved classification of leukemic B-cell lymphoproliferative disorders using a transcriptional and genetic classifier by Navarro, Alba, Clot, Guillem, Martínez-Trillos, Alejandra, Pinyol, Magda, Jares, Pedro, González-Farré, Blanca, Martínez, Daniel, Trim, Nicola, Fernández, Verónica, Villamor, Neus, Colomer, Dolors, Costa, Dolors, Salaverria, Itziar, Martín-Garcia, David, Erber, Wendy, López, Cristina, Jayne, Sandrine, Siebert, Reiner, Dyer, Martin J S, Wiestner, Adrian, Wilson, Wyndham H, Aymerich, Marta, López-Guillermo, Armando, Sánchez, Àlex, Campo, Elías, Matutes, Estella, Beà, Sílvia

“…B-cell chronic lymphoproliferative disorders (B-CLPD) encompass a group of hematologic tumors that often present with leukemic involvement.1 Their…”
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