Search Results - "JAPOUR, A. J"

Identification of Genotypic Changes in Human Immunodeficiency Virus Protease That Correlate with Reduced Susceptibility to the Protease Inhibitor Lopinavir among Viral Isolates from Protease Inhibitor-Experienced Patients by Kempf, D J, Isaacson, J D, King, M S, Brun, S C, Xu, Y, Real, K, Bernstein, B M, Japour, A J, Sun, E, Rode, R A

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Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease by Race, Elizabeth M, Adelson-Mitty, Jennifer, Kriegel, Gila R, Barlam, Tamar F, Reimann, Keith A, Letvin, Norman L, Japour, Anthony J

“…Inhibitors of HIV-1 protease produce a rapid decrease in plasma HIV-1 RNA, with concomitant increases in CD4 T-helper lymphocyte counts. The main side-effects…”
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Association of Plasma Human Immunodeficiency Virus Type 1 RNA Level with Risk of Clinical Progression in Patients with Advanced Infection by Coombs, R. W., Welles, S. L., Hooper, C., Reichelderfer, P. S., D'Aquila, R. T., Japour, A. J., Johnson, V. A., Kuritzkes, D. R., Richman, D. D., Kwok, S., Todd, J., Jackson, J. B., DeGruttola, V., Crumpacker, C. S., Khan, J.

“…Human immunodeficiency virus (HIV)-l RNA level in plasma was evaluated as a surrogate marker for disease progression in a clinical trial of advanced HIV-1…”
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The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir by KEMPF, D. J, RODE, R. A, LEONARD, J. M, YI XU, SUN, E, HEATH-CHIOZZI, M. E, VALDES, J, JAPOUR, A. J, DANNER, S, BOUCHER, C, MOLLA, A

“…To determine markers that are associated with the durability of virologic response to therapy with HIV protease inhibitors in HIV-infected individuals. This…”
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Ritonavir and saquinavir combination therapy for the treatment of HIV infection by CAMERON, D. W, JAPOUR, A. J, ANGEL, Jon B, MCMAHON, D, HO, D, DEVANARAYAN, V, RODE, R, SALGO, M. P, KEMPF, D. J, GRANNEMAN, R, LEONARD, J. M, SUN, E, YI XU, ANN HSU, MELLORS, J, FARTHING, C, COHEN, C, PORETZ, D, MARKOWITZ, M, FOLLANSBEE, S

“…To evaluate the safety and antiretroviral activity of ritonavir (Norvir) and saquinavir (Invirase) combination therapy in patients with HIV infection. A…”
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Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates by JAPOUR, A. J, MAYERS, D. L, CRUMPACKER, C. S, JOHNSON, V. A, KURITZKES, D. R, BECKETT, L. A, ARDUINO, J.-M, LANE, J, BLACK, R. J, REICHELDERFER, P. S, D'AQUILA, R. T

“…A standardized antiviral drug susceptibility assay for clinical human immunodeficiency virus type 1 (HIV-1) isolates has been developed for use in clinical…”
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Prevalence and Clinical Significance of Zidovudine Resistance Mutations in Human Immunodeficiency Virus Isolated from Patients after Long-Term Zidovudine Treatment by Japour, A. J., Welles, S., D'Aquila, R. T., Johnson, V. A., Richman, D. D., Coombs, R. W., Reichelderfer, P. S., Kahn, J. O., Crumpacker, C. S., Kuritzkes, D. R.

“…Zidovudine resistance mutations at reverse. transcriptase codons 215 or 41 were found in two-thirds of human immunodeficiency virus type 1 (HIV-1) isolates…”
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Selective vertical transmission of HIV-1 antiretroviral resistance mutations by COLGROVE, R. C, PITT, J, PEI HUA CHUNG, WELLES, S. L, JAPOUR, A. J

“…To examine the patterns of vertical transmission of zidovudine (ZDV) resistance mutations. HIV-1 reverse transcriptase codons 10-250 were sequenced from 24…”
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HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission in the Women and Infants transmission study by WELLES, S. L, PITT, J, MOYE, J, RICH, K. C, ZORRILLA, C, JAPOUR, A. J, COLGROVE, R, MCINTOSH, K, PEI HUA CHUNG, COLSON, A, LOCKMAN, S, FOWLER, M. G, HANSON, C, LANDESMAN, S

“…Objectives: Although the treatment of pregnant women and their infants with zidovudine (ZDV) has been remarkably effective in preventing the perinatal…”
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Standardized microtiter assay for determination of syncytium-inducing phenotypes of clinical human immunodeficiency virus type 1 isolates by JAPOUR, A. J, FISCUS, S. A, ARDUINO, J.-M, MAYERS, D. L, REICHELDERFER, P. S, KURITZKES, D. R

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Prognostic Value of Plasma Human Immunodeficiency Virus Type 1 (HIV-1) RNA Levels in Patients with Advanced HIV-1 Disease and with Little or No Prior Zidovudine Therapy by Welles, S. L., Jackson, J. B., Yen-Lieberman, B., Demeter, L., Japour, A. J., Smeaton, L. M., Johnson, V. A., Kuritzkes, D. R., D'Aquila, R. T., Reichelderfer, P. A., Richman, D. D., Reichman, R., Fischl, M., Dolin, R., Coombs, R. W., Kahn, J. O., McLaren, C., Todd, J., Kwok, S., Crumpacker, C. S.

“…The association of plasma human immunodeficiency virus type 1 (HIV-1) RNA level at study entry and over time with clinical progression was evaluated in 187…”
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The effect of treatment intensification in HIV-infection : A study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine by GISOLF, E. H, JURRIAANS, S, PELGROM, J, VAN WANZEELE, F, VAN DER ENDE, M. E, BRINKMAN, K, BORST, M.-J, DE WOLF, F, JAPOUR, A. J, DANNER, S. A

“…Objective: To evaluate the effect of treatment with ritonavir (RTV)/saquinavir (SQV)/stavudine (D4T) or RTV/SQV alone, with treatment intensification if…”
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Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization by Japour, A J, Chatis, P A, Eigenrauch, H A, Crumpacker, C S

“…A quantitative rapid assay to detect resistant clinical human immunodeficiency virus type 1 (HIV-1) strains remains an important medical goal. A system…”
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A phase-I study of the safety, pharmacokinetics, and antiviral activity of combination didanosine and ribavirin in patients with HIV-1 disease by JAPOUR, A. J, LERTORA, J. J, COONEY, E, POLLARD, R, TIMPONE, J, MCLAREN, C, JOHANNESON, N, WOOD, K, BOOTH, D. K, BASSIAKOS, Y, CRUMPACKER, C. S, MEEHAN, P. M, ERICE, A, CONNOR, J. D, GRIFFITH, B. P, CLAX, P. A, HOLDEN-WILTSE, J, HUSSEY, S, WALESKY, M

“…A phase-I study was conducted to examine the safety, pharmacokinetics, and activity of combination 2',3'-dideoxyinosine (ddI) and ribavirin against human…”
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ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease by SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A

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Standardized peripheral blood mononuclear cell culture assay for zidovudine susceptibility testing of clinical human immunodeficiency virus type 1 isolates: effect of reducing the numbers of replicates and concentrations by MARSCHNER, I. C, MAYERS, D. L, ERICE, A, SMEATON, L, JOHNSON, V. A, RICHMAN, D. D, REICHELDERFER, P, JAPOUR, A. J

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Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy by Mayers, D L, Japour, A J, Arduino, J-M, Hammer, S M, Reichman, R, Wagner, K F, Chung, R, Lane, J, Crumpacker, C S

“…Human immunodeficiency virus type 1 (HIV-1) isolates resistant to zidovudine (ZDV) have previously been demonstrated to exhibit in vitro cross-resistance to…”
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Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy by D'AQUILA, R. T, JOHNSON, V. A, RICHMAN, D. D, WELLES, S. L, JAPOUR, A. J, KURITZKES, D. R, DEGRUTTOLA, V, REICHELDERFER, P. S, COOMBS, R. W, CRUMPACKER, C. S, KAHN, J. O

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Interlaboratory comparison of sequence-specific PCR and ligase detection reaction to detect a human immunodeficiency virus type 1 drug resistance mutation by SHAFER, R. W, WINTERS, M. A, PENA, F, DIMITROV, D, FRENKEL, L. M, REICHELDERFER, P. S, MAYERS, D. L, JAPOUR, A. J, KURITZKES, D. R, WEISLOW, O. S, WHITE, F, ERICE, A, SANNERUD, K. J, IVERSEN, A

“…Sequence-specific PCR was used in six laboratories and a ligase detection reaction was used in one laboratory to detect the zidovudine-resistance mutation at…”
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Scientific and Ethical Considerations in Trial Design for Investigational Agents for the Treatment of Human Immunodeficiency Virus Infection by Feinberg, Judith, Japour, Anthony J.

“…The design of clinical trials for new antiretroviral agents poses unique challenges, given the availability of highly active antiretroviral therapy (HAART)…”
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