Search Results - "JANKOWSKI, Janusz A"

The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria by Sharma, Prateek, Dent, John, Armstrong, David, Bergman, Jacques J.G.H.M., Gossner, Liebwin, Hoshihara, Yoshio, Jankowski, Janusz A., Junghard, Ola, Lundell, Lars, Tytgat, Guido N.J., Vieth, Michael

“…Background & Aims: Barrett’s esophagus (BE) is a premalignant condition for esophageal adenocarcinoma, its diagnosis relying initially on recognition of a…”
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Detection of Intestinal Metaplasia in Barrett's Esophagus: An Observational Comparator Study Suggests the Need for a Minimum of Eight Biopsies by HARRISON, Rebecca, PERRY, Ian, HADDADIN, William, MCDONALD, Stuart, BRYAN, Richard, ABRAMS, Keith, SAMPLINER, Richard, TALLEY, Nicholas J, MOAYYEDI, Paul, JANKOWSKI, Janusz A

“…Intestinal metaplasia (IM) and dysplasia in Barrett's esophagus are recognized surrogates for esophageal adenocarcinoma risk. While few would argue with the…”
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Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor by Nicholson, Anna M, Graham, Trevor A, Simpson, Ashley, Humphries, Adam, Burch, Nicola, Rodriguez-Justo, Manuel, Novelli, Marco, Harrison, Rebecca, Wright, Nicholas A, McDonald, Stuart A C, Jankowski, Janusz A

“…Little is known about the stem cell organisation of the normal oesophagus or Barrett's metaplastic oesophagus. Using non-pathogenic mitochondrial DNA mutations…”
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Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus by Pan, Qiuwei, Nicholson, Anna M, Barr, Hugh, Harrison, Lea–Anne, Wilson, George D, Burkert, Julia, Jeffery, Rosemary, Alison, Malcolm R, Looijenga, Leendert, Lin, Wey–Ran, McDonald, Stuart A.C, Wright, Nicholas A, Harrison, Rebecca, Peppelenbosch, Maikel P, Jankowski, Janusz A

“…Background & Aims The existence of slowly cycling, adult stem cells has been challenged by the identification of actively cycling cells. We investigated the…”
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Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas by Thirlwell, Christina, Will, Olivia C.C, Domingo, E, Graham, Trevor A, McDonald, Stuart A.C, Oukrif, Dahmane, Jeffrey, Rosemary, Gorman, Maggie, Rodriguez–Justo, Manuel, Chin–Aleong, Joanne, Clark, Sue K, Novelli, Marco R, Jankowski, Janusz A, Wright, Nicholas A, Tomlinson, Ian P.M, Leedham, Simon J

“…Background & Aims According to the somatic mutation theory, monoclonal colorectal lesions arise from sequential mutations in the progeny of a single stem cell…”
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Mitochondrial DNA Mutations Are Established in Human Colonic Stem Cells, and Mutated Clones Expand by Crypt Fission by Greaves, Laura C., Preston, Sean L., Tadrous, Paul J., Taylor, Robert W., Barron, Martin J., Oukrif, Dahmane, Leedham, Simon J., Deheragoda, Maesha, Sasieni, Peter, Novelli, Marco R., Jankowski, Janusz A. Z., Turnbull, Douglass M., Wright, Nicholas A., McDonald, Stuart A. C.

“…The understanding of the fixation of mutations within human tissues and their subsequent clonal expansion is a considerable problem, of which little is known…”
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The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach by Gutierrez–Gonzalez, Lydia, Graham, Trevor A, Rodriguez–Justo, Manuel, Leedham, Simon J, Novelli, Marco R, Gay, Laura J, Ventayol–Garcia, Tania, Green, Alicia, Mitchell, Ian, Stoker, David L, Preston, Sean L, Bamba, Shigeki, Yamada, Eiji, Kishi, Yuuki, Harrison, Rebecca, Jankowski, Janusz A, Wright, Nicholas A, McDonald, Stuart A.C

“…Background & Aims Studies of the clonal architecture of gastric glands with intestinal metaplasia are important in our understanding of the progression from…”
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Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo by MILICIC, Anita, HARRISON, Lea-Anne, EAST, Philip, OBSZYNSKA, Jolanta, SANDERS, Scott, PIAZUELO, Elena, SHAW, Jacqui, HARRISON, Rebecca, TOMLINSON, Ian P, MCDONALD, Stuart A. C, WRIGHT, Nicholas A, JANKOWSKI, Janusz A. Z, GOODLAD, Robert A, HARDY, Robert G, NICHOLSON, Anna M, PRESZ, Michal, SIEBER, Oliver, SANTANDER, Sonia, PRINGLE, James H, MANDIR, Nikki

“…P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be…”
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Aspirin and NSAIDs; benefits and harms for the gut by Thiagarajan, Prarthana, MBBS (Lond), BSc (Lond), Jankowski, Janusz A., MSc (Oxon), MD (Dund), PhD (Lond), FRCP (Lond)

“…Despite modern advances in cancer research, screening and treatment options, gastrointestinal tumours remain a leading cause of death worldwide. Both…”
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Chemoprevention of colorectal cancer by Das, Debasish, Arber, Nadir, Jankowski, Janusz A

“…Colorectal cancer is a major cause of mortality and treatment costs are considerable. Advocating lifestyle modification, faecal occult blood testing and…”
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Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations by Gutierrez-Gonzalez, Lydia, Deheragoda, Maesha, Elia, George, Leedham, Simon J, Shankar, Arjun, Imber, Charles, Jankowski, Janusz A, Turnbull, Douglass M, Novelli, Marco, Wright, Nicholas A, McDonald, Stuart AC

“…Little is known about the clonal structure or stem cell architecture of the human small intestinal crypt/villus unit, or how mutations spread and become fixed…”
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Molecular Evolution of the Metaplasia-Dysplasia-Adenocarcinoma Sequence in the Esophagus by Jankowski, Janusz A., Wright, Nick A., Meltzer, Stephen J., Triadafilopoulos, George, Geboes, Karl, Casson, Alan G., Kerr, David, Young, Lawrence S.

“…The incidence of adenocarcinoma of the esophagus has been increasing in developing countries over the last three decades and probably reflects a genuine…”
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Guidelines for the management of oesophageal and gastric cancer by Allum, William H, Blazeby, Jane M, Griffin, S Michael, Cunningham, David, Jankowski, Janusz A, Wong, Rachel

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British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus by Fitzgerald, Rebecca C, di Pietro, Massimiliano, Ragunath, Krish, Ang, Yeng, Kang, Jin-Yong, Watson, Peter, Trudgill, Nigel, Patel, Praful, Kaye, Philip V, Sanders, Scott, O'Donovan, Maria, Bird-Lieberman, Elizabeth, Bhandari, Pradeep, Jankowski, Janusz A, Attwood, Stephen, Parsons, Simon L, Loft, Duncan, Lagergren, Jesper, Moayyedi, Paul, Lyratzopoulos, Georgios, de Caestecker, John

“…These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The…”
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Mechanisms of Disease: from stem cells to colorectal cancer by McDonald, Stuart AC, Preston, Sean L, Lovell, Matthew J, Wright, Nicholas A, Jankowski, Janusz AZ

“…Over the past decade, the advances in our understanding of stem cell biology and the role of stem cells in diseases, such as colorectal cancer, have been…”
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Met Receptor Signaling: A Key Effector in Esophageal Adenocarcinoma by ANDERSON, Mark R, HARRISON, Rebecca, ATHERFOLD, Paul A, CAMPBELL, Moray J, DARNTON, S. Jane, OBSZYNSKA, Jolanta, JANKOWSKI, Janusz A. Z

“…Purpose: The incidence of esophageal adenocarcinoma is rising, and survival rates remain poor. The hepatocyte growth factor (HGF) receptor Met has been…”
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Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo by Obszynska, Jolanta A, Atherfold, Paul A, Nanji, Manoj, Glancy, Deborah, Santander, Sonia, Graham, Trevor A, Otto, William R, West, Kevin, Harrison, Rebecca F, Jankowski, Janusz A Z

“…Barrett's oesophagus is a common premalignant lesion caused partly by acid reflux. Although the requisite therapy, proton pump inhibitors (PPIs), have been…”
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Chemoprevention in Barrett's Esophagus: A Pill a Day? by Jankowski, Janusz A., MSc(Oxon), MD(Dund), PhD(Lond), FRCP(Lond), Hooper, Patricia A., MBChB(Leics), BSc(Leics)

“…Esophageal adenocarcinoma is increasing in incidence. The main risk factor is the premalignant condition of Barrett's esophagus. There is great interest in…”
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The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands by Lavery, Danielle L, Nicholson, Anna M, Poulsom, Richard, Jeffery, Rosemary, Hussain, Alia, Gay, Laura J, Jankowski, Janusz A, Zeki, Sebastian S, Barr, Hugh, Harrison, Rebecca, Going, James, Kadirkamanathan, Sritharan, Davis, Peter, Underwood, Timothy, Novelli, Marco R, Rodriguez-Justo, Manuel, Shepherd, Neil, Jansen, Marnix, Wright, Nicholas A, McDonald, Stuart A C

“…Barrett's oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture…”
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Biomarkers in Gastroenterology: Between Hope and Hype Comes Histopathology by JANKOWSKI, Janusz A, ODZE, Robert D

“…Gastrointestinal cancers account for approximately 25% of all cancer deaths in the Western world. There is a need for a preventive strategy that can utilize…”
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