Search Results - "JAN DANSER, A. H"

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure by Arendse, Lauren B, Danser, A H Jan, Poglitsch, Marko, Touyz, Rhian M, Burnett, Jr, John C, Llorens-Cortes, Catherine, Ehlers, Mario R, Sturrock, Edward D

“…Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT R)…”
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Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis by Wang, Na, Ren, Liwei, Danser, A. H. Jan

“…ABSTRACT Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It…”
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Headache medication and the COVID-19 pandemic by MaassenVanDenBrink, Antoinette, de Vries, Tessa, Danser, A. H. Jan

“…The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and…”
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(Pro)renin and its receptors: pathophysiological implications by Batenburg, Wendy W, Danser, A H Jan

“…Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin [together denoted as (pro)renin]. Since…”
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The importance of the nitric oxide‐cGMP pathway in age‐related cardiovascular disease: Focus on phosphodiesterase‐1 and soluble guanylate cyclase by Golshiri, Keivan, Ataei Ataabadi, Ehsan, Portilla Fernandez, Eliana C., Jan Danser, A. H., Roks, Anton J. M.

“…Among ageing‐related illnesses, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality causing one‐third of all deaths worldwide…”
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Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney? by Sun, Yuan, Lu, Xifeng, Danser, A. H. Jan

“…Purpose of Review Megalin is well known for its role in the reabsorption of proteins from the ultrafiltrate. Recent studies suggest that megalin also reabsorbs…”
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The role of DNA methylation and histone modifications in blood pressure: a systematic review by Gonzalez-Jaramillo, Valentina, Portilla-Fernandez, Eliana, Glisic, Marija, Voortman, Trudy, Bramer, Wichor, Chowdhury, Rajiv, Roks, Anton J. M., Jan Danser, A. H., Muka, Taulant, Nano, Jana, Franco, Oscar H.

“…Epigenetic mechanisms might play a role in the pathophysiology of hypertension, a major risk factor for cardiovascular disease and renal failure. We aimed to…”
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Endothelin-1 and antiangiogenesis by Lankhorst, Stephanie, Danser, A H Jan, van den Meiracker, Anton H

“…Antiangiogenesis, targeting vascular endothelial growth factor (VEGF), has become a well-established treatment for patients with cancer. This treatment is…”
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Transplacental Zika virus transmission in ex vivo perfused human placentas by Langerak, Thomas, Broekhuizen, Michelle, Unger, Peter-Paul Alexander, Tan, Lunbo, Koopmans, Marion, van Gorp, Eric, Danser, A H Jan, Rockx, Barry

“…A Zika virus (ZIKV) infection during pregnancy can result in severe birth defects such as microcephaly. To date, it is incompletely understood how ZIKV can…”
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Prorenin and Renin-Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide by Feldt, Sandra, Batenburg, Wendy W, Mazak, Istvan, Maschke, Ulrike, Wellner, Maren, Kvakan, Heda, Dechend, Ralf, Fiebeler, Anette, Burckle, Celine, Contrepas, Aurelie, Danser, A H. Jan, Bader, Michael, Nguyen, Genevieve, Luft, Friedrich C, Muller, Dominik N

“…The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes…”
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Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas by Sun, Yuan, Tan, Lunbo, Neuman, Rugina I., Broekhuizen, Michelle, Schoenmakers, Sam, Lu, Xifeng, Danser, A. H. Jan

“…Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To…”
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MicroRNA-148a regulates low-density lipoprotein metabolism by repressing the (pro)renin receptor by Wang, Na, He, Lishu, Lin, Hui, Tan, Lunbo, Sun, Yuan, Zhang, Xiaoying, Danser, A H Jan, Lu, Hong S, He, Yongcheng, Lu, Xifeng

“…High plasma LDL cholesterol (LDL-c) concentration is a major risk factor for atherosclerosis. Hepatic LDL receptor (LDLR) regulates LDL metabolism, and thereby…”
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Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement by Campbell, Duncan J, Nussberger, Juerg, Stowasser, Michael, Danser, A.H. Jan, Morganti, Alberto, Frandsen, Erik, Menard, Joel

“…Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the…”
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Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia by Sorop, Oana, van den Heuvel, Mieke, van Ditzhuijzen, Nienke S, de Beer, Vincent J, Heinonen, Ilkka, van Duin, Richard W B, Zhou, Zhichao, Koopmans, Sietse J, Merkus, Daphne, van der Giessen, Wim J, Danser, A H Jan, Duncker, Dirk Jan

“…Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mellitus (DM)- and hypercholesterolemia-associated coronary…”
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The macula densa prorenin receptor is essential in renin release and blood pressure control by Riquier-Brison, Anne D M, Sipos, Arnold, Prókai, Ágnes, Vargas, Sarah L, Toma, Lldikó, Meer, Elliott J, Villanueva, Karie G, Chen, Jennifer C M, Gyarmati, Georgina, Yih, Christopher, Tang, Elaine, Nadim, Bahram, Pendekanti, Sujith, Garrelds, Ingrid M, Nguyen, Genevieve, Danser, A H Jan, Peti-Peterdi, János

“…The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association…”
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Urinary renin-angiotensin markers in polycystic kidney disease by Salih, Mahdi, Bovée, Dominique M, Roksnoer, Lodi C W, Casteleijn, Niek F, Bakker, Stephan J L, Gansevoort, Ronald T, Zietse, Robert, Danser, A H Jan, Hoorn, Ewout J

“…In autosomal dominant polycystic kidney disease (ADPKD), activation of the renin-angiotensin aldosterone system (RAAS) may contribute to hypertension and…”
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(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis by Ren, Liwei, Sun, Yuan, Lu, Hong, Ye, Dien, Han, Lijuan, Wang, Na, Daugherty, Alan, Li, Furong, Wang, Miaomiao, Su, Fengting, Tao, Wenjun, Sun, Jie, Zelcer, Noam, Mullick, Adam E, Danser, A.H Jan, Jiang, Yizhou, He, Yongcheng, Ruan, Xiongzhong, Lu, Xifeng

“…RATIONALE:An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the…”
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Renal and Hormonal Responses to Direct Renin Inhibition With Aliskiren in Healthy Humans by FISHER, Naomi D. L, JAN DANSER, A. H, NUSSBERGER, J, DOLE, William P, HOLLENBERG, Norman K

“…Pharmacological interruption of the renin-angiotensin system focuses on optimization of blockade. As a measure of intrarenal renin activity, we have examined…”
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Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression by Kappers, Mariëtte H. W, van Esch, Joep H. M, Smedts, Frank M. M, de Krijger, Ronald R, Eechoute, Karel, Mathijssen, Ron H. J, Sleijfer, Stefan, Leijten, Frank, Danser, A. H. Jan, van den Meiracker, Anton H, Visser, Theo J

“…Context: Anticancer treatment with the tyrosine kinase inhibitor sunitinib causes thyroid dysfunction. Objective: Our objective was to investigate the time…”
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The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System by Kappers, Mariëtte H.W, Smedts, Frank M.M, Horn, Thomas, van Esch, Joep H.M, Sleijfer, Stefan, Leijten, Frank, Wesseling, Sebastiaan, Strevens, Helena, Jan Danser, A.H, van den Meiracker, Anton H

“…Angiogenesis inhibition is an established treatment for several tumor types. Unfortunately, this therapy is associated with adverse effects, including…”
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