Search Results - "JAMES WHITE, R."

Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer by Anagnostou, Valsamo, Forde, Patrick M, White, James R, Niknafs, Noushin, Hruban, Carolyn, Naidoo, Jarushka, Marrone, Kristen, Sivakumar, I K Ashok, Bruhm, Daniel C, Rosner, Samuel, Phallen, Jillian, Leal, Alessandro, Adleff, Vilmos, Smith, Kellie N, Cottrell, Tricia R, Rhymee, Lamia, Palsgrove, Doreen N, Hann, Christine L, Levy, Benjamin, Feliciano, Josephine, Georgiades, Christos, Verde, Franco, Illei, Peter, Li, Qing Kay, Gabrielson, Edward, Brock, Malcolm V, Isbell, James M, Sauter, Jennifer L, Taube, Janis, Scharpf, Robert B, Karchin, Rachel, Pardoll, Drew M, Chaft, Jamie E, Hellmann, Matthew D, Brahmer, Julie R, Velculescu, Victor E

“…Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here, we…”
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Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation by Banerjee, Amrita, Herring, Charles A., Chen, Bob, Kim, Hyeyon, Simmons, Alan J., Southard-Smith, Austin N., Allaman, Margaret M., White, James R., Macedonia, Mary C., Mckinley, Eliot T., Ramirez-Solano, Marisol A., Scoville, Elizabeth A., Liu, Qi, Wilson, Keith T., Coffey, Robert J., Washington, M. Kay, Goettel, Jeremy A., Lau, Ken S.

“…Countries endemic for parasitic infestations have a lower incidence of Crohn’s disease (CD) than nonendemic countries, and there have been anecdotal reports of…”
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Interaction between the microbiome and TP53 in human lung cancer by Greathouse, K Leigh, White, James R, Vargas, Ashely J, Bliskovsky, Valery V, Beck, Jessica A, von Muhlinen, Natalia, Polley, Eric C, Bowman, Elise D, Khan, Mohammed A, Robles, Ana I, Cooks, Tomer, Ryan, Bríd M, Padgett, Noah, Dzutsev, Amiran H, Trinchieri, Giorgio, Pineda, Marbin A, Bilke, Sven, Meltzer, Paul S, Hokenstad, Alexis N, Stickrod, Tricia M, Walther-Antonio, Marina R, Earl, Joshua P, Mell, Joshua C, Krol, Jaroslaw E, Balashov, Sergey V, Bhat, Archana S, Ehrlich, Garth D, Valm, Alex, Deming, Clayton, Conlan, Sean, Oh, Julia, Segre, Julie A, Harris, Curtis C

“…Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung…”
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Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic by Tomkovich, Sarah, Dejea, Christine M, Winglee, Kathryn, Drewes, Julia L, Chung, Liam, Housseau, Franck, Pope, Jillian L, Gauthier, Josee, Sun, Xiaolun, Mühlbauer, Marcus, Liu, Xiuli, Fathi, Payam, Anders, Robert A, Besharati, Sepideh, Perez-Chanona, Ernesto, Yang, Ye, Ding, Hua, Wu, Xinqun, Wu, Shaoguang, White, James R, Gharaibeh, Raad Z, Fodor, Anthony A, Wang, Hao, Pardoll, Drew M, Jobin, Christian, Sears, Cynthia L

“…Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy…”
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Microbiota organization is a distinct feature of proximal colorectal cancers by Dejea, Christine M., Wick, Elizabeth C., Hechenbleikner, Elizabeth M., White, James R., Welch, Jessica L. Mark, Rossetti, Blair J., Peterson, Scott N., Snesrud, Erik C., Borisy, Gary G., Lazarev, Mark, Stein, Ellen, Vadivelu, Jamuna, Roslani, April C., Malik, Ausuma A., Wanyiri, Jane W., Goh, Khean L., Thevambiga, Iyadorai, Fu, Kai, Wan, Fengyi, Llosa, Nicolas, Housseau, Franck, Romans, Katharine, Wu, XinQun, McAllister, Florencia M., Wu, Shaoguang, Vogelstein, Bert, Kinzler, Kenneth W., Pardoll, Drew M., Sears, Cynthia L.

“…Environmental factors clearly affect colorectal cancer (CRC) incidence, but the mechanisms through which these factors function are unknown. One prime…”
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Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants by Sellitto, Maria, Bai, Guoyun, Serena, Gloria, Fricke, W Florian, Sturgeon, Craig, Gajer, Pawel, White, James R, Koenig, Sara S K, Sakamoto, Joyce, Boothe, Dustin, Gicquelais, Rachel, Kryszak, Deborah, Puppa, Elaine, Catassi, Carlo, Ravel, Jacques, Fasano, Alessio

“…Celiac disease (CD) is a unique autoimmune disorder in which the genetic factors (DQ2/DQ8) and the environmental trigger (gluten) are known and necessary but…”
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CloVR: a virtual machine for automated and portable sequence analysis from the desktop using cloud computing by Angiuoli, Samuel V, Matalka, Malcolm, Gussman, Aaron, Galens, Kevin, Vangala, Mahesh, Riley, David R, Arze, Cesar, White, James R, White, Owen, Fricke, W Florian

“…Next-generation sequencing technologies have decentralized sequence acquisition, increasing the demand for new bioinformatics tools that are easy to use,…”
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Enrichment dynamics of Listeria monocytogenes and the associated microbiome from naturally contaminated ice cream linked to a listeriosis outbreak by Ottesen, Andrea, Ramachandran, Padmini, Reed, Elizabeth, White, James R, Hasan, Nur, Subramanian, Poorani, Ryan, Gina, Jarvis, Karen, Grim, Christopher, Daquiqan, Ninalynn, Hanes, Darcy, Allard, Marc, Colwell, Rita, Brown, Eric, Chen, Yi

“…Microbiota that co-enrich during efforts to recover pathogens from foodborne outbreaks interfere with efficient detection and recovery. Here, dynamics of…”
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Batch effects removal for microbiome data via conditional quantile regression by Ling, Wodan, Lu, Jiuyao, Zhao, Ni, Lulla, Anju, Plantinga, Anna M., Fu, Weijia, Zhang, Angela, Liu, Hongjiao, Song, Hoseung, Li, Zhigang, Chen, Jun, Randolph, Timothy W., Koay, Wei Li A., White, James R., Launer, Lenore J., Fodor, Anthony A., Meyer, Katie A., Wu, Michael C.

“…Batch effects in microbiome data arise from differential processing of specimens and can lead to spurious findings and obscure true signals. Strategies…”
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Metabolism Links Bacterial Biofilms and Colon Carcinogenesis by Johnson, Caroline H., Dejea, Christine M., Edler, David, Hoang, Linh T., Santidrian, Antonio F., Felding, Brunhilde H., Ivanisevic, Julijana, Cho, Kevin, Wick, Elizabeth C., Hechenbleikner, Elizabeth M., Uritboonthai, Winnie, Goetz, Laura, Casero, Robert A., Pardoll, Drew M., White, James R., Patti, Gary J., Sears, Cynthia L., Siuzdak, Gary

“…Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in colon cancer metabolism has been suggested but to date has not…”
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A machine learning approach for somatic mutation discovery by Wood, Derrick E, White, James R, Georgiadis, Andrew, Van Emburgh, Beth, Parpart-Li, Sonya, Mitchell, Jason, Anagnostou, Valsamo, Niknafs, Noushin, Karchin, Rachel, Papp, Eniko, McCord, Christine, LoVerso, Peter, Riley, David, Diaz, Jr, Luis A, Jones, Siân, Sausen, Mark, Velculescu, Victor E, Angiuoli, Samuel V

“…Variability in the accuracy of somatic mutation detection may affect the discovery of alterations and the therapeutic management of cancer patients. To address…”
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Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA by Wan, Jonathan C. M., Stephens, Dennis, Luo, Lingqi, White, James R., Stewart, Caitlin M., Rousseau, Benoît, Tsui, Dana W. Y., Diaz, Luis A.

“…Mutational signatures accumulate in somatic cells as an admixture of endogenous and exogenous processes that occur during an individual’s lifetime. Since…”
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Tadalafil Therapy for Pulmonary Arterial Hypertension by GALIE, Nazzareno, BRUNDAGE, Bruce H, FRUMKIN, Lyn, BARST, Robyn J, GHOFRANI, Hossein A, OUDIZ, Ronald J, SIMONNEAU, Gerald, SAFDAR, Zeenat, SHAPIRO, Shelley, WHITE, R. James, CHAN, Melanie, BEARDSWORTH, Anthony

“…Treatment options for pulmonary arterial hypertension target the prostacyclin, endothelin, or nitric oxide pathways. Tadalafil, a phosphodiesterase type-5…”
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Novel Analysis of the Oral Treprostinil Combination Therapy Trial Data by White, R James, Rao, Youlan

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The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department by Wright, Colin, Elbadawi, Ayman, Chen, Yu Lin, Patel, Dhwani, Mazzillo, Justin, Acquisto, Nicole, Groth, Christine, Van Galen, Joseph, Delehanty, Joseph, Pietropaoli, Anthony, Trawick, David, James White, R., Cameron, Pamela, Gosev, Igor, Barrus, Bryan, Kumar, Neil G., Cameron, Scott J.

“…The concept of a pulmonary embolism response team (PERT) is multidisciplinary, with the hope that it may positively impact patient care, hospital efficiency,…”
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Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment with anti-PD-1 (pembrolizumab) by Peiffer, Lauren B., White, James R., Jones, Carli B., Slottke, Rachel E., Ernst, Sarah E., Moran, Amy E., Graff, Julie N., Sfanos, Karen S.

“…Recent studies in cancer patients and animal models demonstrate that intestinal microbiota influence the therapeutic efficacy of cancer treatments, including…”
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Baseline survey of the anatomical microbial ecology of an important food plant: Solanum lycopersicum (tomato) by Ottesen, Andrea R, González Peña, Antonio, White, James R, Pettengill, James B, Li, Cong, Allard, Sarah, Rideout, Steven, Allard, Marc, Hill, Thomas, Evans, Peter, Strain, Errol, Musser, Steven, Knight, Rob, Brown, Eric

“…Research to understand and control microbiological risks associated with the consumption of fresh fruits and vegetables has examined many environments in the…”
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High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia by Drewes, Julia L., White, James R., Dejea, Christine M., Fathi, Payam, Iyadorai, Thevambiga, Vadivelu, Jamuna, Roslani, April C., Wick, Elizabeth C., Mongodin, Emmanuel F., Loke, Mun Fai, Thulasi, Kumar, Gan, Han Ming, Goh, Khean Lee, Chong, Hoong Yin, Kumar, Sandip, Wanyiri, Jane W., Sears, Cynthia L.

“…Colorectal cancer (CRC) remains the third most common cancer worldwide, with a growing incidence among young adults. Multiple studies have presented…”
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Resting heart rate as a surrogate for improvement in intermediate risk pulmonary embolus patients? by Roto, Dominick, Lachant, Neil A., James White, R., Lachant, Daniel J.

“…Pulmonary embolism (PE) response teams (PERT) have been developed to improve in-hospital mortality. Identifying intermediate risk PE patients that will…”
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A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors by Shaikh, Fyza Y, White, James R, Gills, Joell J, Hakozaki, Taiki, Richard, Corentin, Routy, Bertrand, Okuma, Yusuke, Usyk, Mykhaylo, Pandey, Abhishek, Weber, Jeffrey S, Ahn, Jiyoung, Lipson, Evan J, Naidoo, Jarushka, Pardoll, Drew M, Sears, Cynthia L

“…While immune checkpoint inhibitors (ICI) have revolutionized the treatment of cancer by producing durable antitumor responses, only 10%-30% of treated patients…”
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