Search Results - "JAMES, Alan L"

Fatty airways: implications for obstructive disease by Elliot, John G, Donovan, Graham M, Wang, Kimberley C W, Green, Francis H Y, James, Alan L, Noble, Peter B

“…Epidemiological studies report that overweight or obese asthmatic subjects have more severe disease than those of a healthy weight. We postulated that…”
Get full text

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma by Taylor, Steven L, Leong, Lex E X, Mobegi, Fredrick M, Choo, Jocelyn M, Wesselingh, Steve, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Jenkins, Christine, Peters, Matthew J, Baraket, Melissa, Marks, Guy B, Gibson, Peter G, Rogers, Geraint B, Simpson, Jodie L

“…The macrolide antibiotic azithromycin reduces exacerbations in adults with persistent symptomatic asthma. However, owing to the pleotropic properties of…”
Get full text

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life by Bui, Dinh S, Lodge, Caroline J, Burgess, John A, Lowe, Adrian J, Perret, Jennifer, Bui, Minh Q, Bowatte, Gayan, Gurrin, Lyle, Johns, David P, Thompson, Bruce R, Hamilton, Garun S, Frith, Peter A, James, Alan L, Thomas, Paul S, Jarvis, Deborah, Svanes, Cecilie, Russell, Melissa, Morrison, Stephen C, Feather, Iain, Allen, Katrina J, Wood-Baker, Richard, Hopper, John, Giles, Graham G, Abramson, Michael J, Walters, Eugene H, Matheson, Melanie C, Dharmage, Shyamali C

“…Lifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification…”
Get full text

Respiratory impedance in healthy subjects: baseline values and bronchodilator response by OOSTVEEN, Ellie, BODA, Krisztina, VAN DER GRINTEN, Chris P. M, JAMES, Alan L, YOUNG, Sally, NIELAND, Hans, HANTOS, Zoltán

“…Because of the minimal demand for cooperation by the subject, the forced oscillation technique is increasingly employed in routine lung function testing…”
Get full text

Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma by JAMES, Alan L, ELLIOT, John G, JONES, Robyn L, CARROLL, Mark L, MAUAD, Thais, BAI, Tony R, ABRAMSON, Michael J, MCKAY, Karen O, GREEN, Francis H

“…Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular…”
Get full text

Unraveling a Clinical Paradox: Why Does Bronchial Thermoplasty Work in Asthma? by Donovan, Graham M, Elliot, John G, Green, Francis H Y, James, Alan L, Noble, Peter B

“…Bronchial thermoplasty is a relatively new but seemingly effective treatment in subjects with asthma who do not respond to conventional therapy. Although the…”
Get full text

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment by Niessen, Natalie M., Gibson, Peter G., Baines, Katherine J., Barker, Daniel, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Simpson, Jodie L., Fricker, Michael

“…Background The AMAZES randomized controlled trial demonstrated that long‐term low‐dose azithromycin treatment reduces exacerbations of poorly controlled…”
Get full text

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma by Fricker, Michael, Gibson, Peter G., Powell, Heather, Simpson, Jodie L., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Baines, Katherine J.

“…Improved diagnostic tools for predicting future exacerbation frequency in asthmatic patients are required. A sputum gene expression signature of 6 biomarkers…”
Get full text

Structure and function of small airways in asthma patients revisited by van den Bosch, Wytse B, James, Alan L, Tiddens, Harm A W M

“…Small airways (<2 mm in diameter) are probably involved across almost all asthma severities and they show proportionally more structural and functional…”
Get full text

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids by Simpson, Jodie L., PhD, Carroll, Melanie, BS, Yang, Ian A., PhD, Reynolds, Paul N., PhD, Hodge, Sandra, PhD, James, Alan L., MBBS, PhD, Gibson, Peter G., MBBS, Upham, John W., PhD

“…Background Asthma is a heterogeneous chronic inflammatory disease in which host defense against respiratory viruses such as human rhinovirus (HRV) may be…”
Get full text

Airway smooth muscle proliferation and inflammation in asthma by James, Alan L, Noble, Peter B, Drew, Su-Ann, Mauad, Thais, Bai, Tony R, Abramson, Michael J, McKay, Karen O, Green, Francis H Y, Elliot, John G

“…In asthma, it is unclear if the airway smooth muscle cells proliferate more or are increased at the onset of asthma and remain stable. This study aimed to…”
Get full text

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy by Asai, Yuka, Eslami, Aida, van Ginkel, C. Dorien, Akhabir, Loubna, Wan, Ming, Ellis, George, Ben-Shoshan, Moshe, Martino, David, Ferreira, Manuel A., Allen, Katrina, Mazer, Bruce, de Groot, Hans, de Jong, Nicolette W., Gerth van Wijk, Roy N., Dubois, Anthony E.J., Chin, Rick, Cheuk, Stephen, Hoffman, Joshua, Jorgensen, Eric, Witte, John S., Melles, Ronald B., Hong, Xiumei, Wang, Xiaobin, Hui, Jennie, Musk, Arthur W. (Bill), Hunter, Michael, James, Alan L., Koppelman, Gerard H., Sandford, Andrew J., Clarke, Ann E., Daley, Denise

“…Peanut allergy (PA) is a complex disease with both environmental and genetic risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in…”
Get full text

Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size? by Donovan, Graham M, Wang, Kimberley C W, Elliot, John G, James, Alan L, Noble, Peter B

Get full text

Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade by Bui, Dinh S, Walters, Haydn E, Burgess, John A, Perret, Jennifer L, Bui, Minh Q, Bowatte, Gayan, Lowe, Adrian J, Russell, Melissa A, Thompson, Bruce R, Hamilton, Garun S, James, Alan L, Giles, Graham G, Thomas, Paul S, Jarvis, Debbie, Svanes, Cecilie, Garcia-Aymerich, Judith, Erbas, Bircan, Frith, Peter A, Allen, Katrina J, Abramson, Michael J, Lodge, Caroline J, Dharmage, Shyamali C

“…Childhood risk factors for long-term lung health often coexist and their specific patterns may affect subsequent lung function differently. To identify…”
Get full text

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner by Wang, Kimberley C W, Larcombe, Alexander N, Berry, Luke J, Morton, Jude S, Davidge, Sandra T, James, Alan L, Noble, Peter B

“…Epidemiological studies demonstrate an association between intrauterine growth restriction (IUGR) and asthma; however the underlying mechanism is unknown. We…”
Get more information

The cost-effectiveness of azithromycin in reducing exacerbations in uncontrolled asthma by O'Neill, Ciaran, Gibson, Peter G, Heaney, Liam G, Upham, John W, Yang, Ian A, Reynolds, Paul N, Hodge, Sandra, Jenkins, Christine R, Peters, Matthew, Marks, Guy B, James, Alan L, Simpson, Jodie L

“…Add-on azithromycin (AZM) results in a significant reduction in exacerbations among adults with persistent uncontrolled asthma. The aim of this study was to…”
Get full text

Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study by Hunter, Michael L, Knuiman, Matthew W, Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P, Hillman, David R, Hung, Joseph, Newton, Robert U, Bucks, Romola S, Straker, Leon, Walsh, John P, Zhu, Kun, Bruce, David G, Eikelboom, Robert H, Davis, Timothy M. E, Mackey, David A, James, Alan L

“…Abstract Background and objective Chronic medical conditions accumulate within individuals with age. However, knowledge concerning the trends, patterns and…”
Get full text

Interrelationships between body mass, oxygen desaturation, and apnea-hypopnea indices in a sleep clinic population by Ling, Ivan T, James, Alan L, Hillman, David R

“…To investigate the relationship between oxygen desaturation index (ODI), body mass index (BMI), and apnea-hypopnea index (AHI) in a large sleep clinic…”
Get full text

Independent and combined effects of airway remodelling and allergy on airway responsiveness by Wang, Kimberley C W, Le Cras, Timothy D, Larcombe, Alexander N, Zosky, Graeme R, Elliot, John G, James, Alan L, Noble, Peter B

“…Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The…”
Get more information

The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics by Rosner, Sonia R, Pascoe, Christopher D, Blankman, Elizabeth, Jensen, Christopher C, Krishnan, Ramaswamy, James, Alan L, Elliot, John G, Green, Francis H, Liu, Jeffrey C, Seow, Chun Y, Park, Jin-Ah, Beckerle, Mary C, Paré, Peter D, Fredberg, Jeffrey J, Smith, Mark A

“…Bronchospasm induced in non-asthmatic human subjects can be easily reversed by a deep inspiration (DI) whereas bronchospasm that occurs spontaneously in…”
Get full text