Search Results - "JAMEI M"

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine by Jamei, M., Bajot, F., Neuhoff, S., Barter, Z., Yang, J., Rostami-Hodjegan, A., Rowland-Yeo, K.

“…Background and Objectives The interplay between liver metabolising enzymes and transporters is a complex process involving system-related parameters such as…”
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Crack patterns in clayey soils: Experiments and modeling by Trabelsi, H., Jamei, M., Zenzri, H., Olivella, S.

“…SUMMARY The paper presents an experimental and numerical study to investigate the behavior of desiccated clayey soils. The performed tests permit to evaluate…”
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VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays by Fisher, C., Siméon, S., Jamei, M., Gardner, I., Bois, Y.F.

“…In vitro toxicity testing routinely uses nominal treatment concentrations as the driver for measured toxicity endpoints. However, test compounds can bind to…”
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ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans by Zamek-Gliszczynski, M J, Lee, C A, Poirier, A, Bentz, J, Chu, X, Ellens, H, Ishikawa, T, Jamei, M, Kalvass, J C, Nagar, S, Pang, K S, Korzekwa, K, Swaan, P W, Taub, M E, Zhao, P, Galetin, A

“…This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various…”
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Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model by Darwich, A S, Neuhoff, S, Jamei, M, Rostami-Hodjegan, A

“…Bioavailability of orally administered drugs can be influenced by a number of factors including release from the formulation, dissolution, stability in the…”
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Development and applications of a physiologically-based model of paediatric oral drug absorption by Johnson, T.N., Bonner, J.J., Tucker, G.T., Turner, D.B., Jamei, M.

“…There is increasing interest in paediatric drug absorption and the development of biopharmaceutics tools to facilitate the development of oral formulations for…”
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A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease-Drug Interactions: Suppression of CYP3A by IL-6 by Machavaram, K K, Almond, L M, Rostami-Hodjegan, A, Gardner, I, Jamei, M, Tay, S, Wong, S, Joshi, A, Kenny, J R

“…Elevated cytokine levels are known to downregulate expression and suppress activity of cytochrome P450 enzymes (CYPs). Cytokine‐modulating therapeutic proteins…”
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A New Type of Euler Polynomials and Numbers by Masjed-Jamei, M., Beyki, M. R., Koepf, W.

“…By defining two specific exponential generating functions, we introduce a kind of Euler polynomials and study its basic properties in detail. As an application…”
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Application of the MechPeff model to predict passive effective intestinal permeability in the different regions of the rodent small intestine and colon by Pade, D., Jamei, M., Rostami‐Hodjegan, A., Turner, D.B.

“…A major component of physiologically based pharmacokinetic (PBPK) models is the prediction of the rate and extent of absorption of orally dosed drugs for which…”
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Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions by Burt, H.J., Neuhoff, S., Almond, L., Gaohua, L., Harwood, M.D., Jamei, M., Rostami-Hodjegan, A., Tucker, G.T., Rowland-Yeo, K.

“…Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs with new chemical entities. The aim of the current study was to…”
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Shear Failure Criterion Based on Experimental and Modeling Results for Fiber-Reinforced Clay by Jamei, M, Villard, P, Guiras, H

“…AbstractThe present paper deals with an experimental study and an analytical model set up to predict the shear resistance of clay reinforced by short fibers in…”
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Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model by Almond, Lisa M, Mukadam, Sophie, Gardner, Iain, Okialda, Krystle, Wong, Susan, Hatley, Oliver, Tay, Suzanne, Rowland-Yeo, Karen, Jamei, Masoud, Rostami-Hodjegan, Amin, Kenny, Jane R

“…Using physiologically based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with rifampicin and seven CYP3A4…”
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Prediction of time-dependent CYP3A4 drug–drug interactions by physiologically based pharmacokinetic modelling: Impact of inactivation parameters and enzyme turnover by Rowland Yeo, K., Walsky, R.L., Jamei, M., Rostami-Hodjegan, A., Tucker, G.T.

“…Predicting the magnitude of time-dependent metabolic drug–drug (mDDIs) interactions involving cytochrome P-450 3A4 (CYP3A4) from in vitro data requires…”
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On a Bivariate Kind of Q-Euler and Q-Genocchi Polynomials by Masjed-Jamei, M., Beyki, M. R.

“…We introduce two bivariate kinds of q -Euler and q -Genocchi polynomials and formulate and prove their basic properties…”
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Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report of an FDA Public Workshop by Zhang, X, Duan, J, Kesisoglou, F, Novakovic, J, Amidon, GL, Jamei, M, Lukacova, V, Eissing, T, Tsakalozou, E, Zhao, L, Lionberger, R

“…On May 19, 2016, the US Food and Drug Administration (FDA) hosted a public workshop, entitled “Mechanistic Oral Absorption Modeling and Simulation for…”
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Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1‐Related Variability in Pharmacodynamics of Rosuvastatin by Rose, RH, Neuhoff, S, Abduljalil, K, Chetty, M, Rostami‐Hodjegan, A, Jamei, M

“…Typically, pharmacokinetic–pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability…”
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(p,q)‐Sturm‐Liouville problems and their orthogonal solutions by Soleyman, F., Sadjang, P. Njionou, Masjed‐Jamei, M., Area, I.

“…In this paper, we introduce (p,q)‐Sturm‐Liouville problems and prove that their solutions are orthogonal with respect to a (p,q)‐integral space. We then…”
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Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction by Almond, L M, Yang, J, Jamei, M, Tucker, G T, Rostami-Hodjegan, A

“…Although CYP induction is not generally considered to be as clinically relevant as CYP inhibition, there are important examples where induction has caused both…”
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Water retention properties of perlite as a material with crushable soft particles by Jamei, M., Guiras, H., Chtourou, Y., Kallel, A., Romero, E., Georgopoulos, I.

“…The purpose of this study is to present and discuss the experimental results of the water retention properties of an unsaturated material with crushable soft…”
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Physiologically-based pharmacokinetic (PBPK) models for assessing the kinetics of xenobiotics during pregnancy: achievements and shortcomings by Lu, G, Abduljalil, K, Jamei, M, Johnson, T N, Soltani, H, Rostami-Hodjegan, A

“…The physiological changes that occur in the maternal body and the placental-foetal unit during pregnancy influence the absorption, distribution, metabolism,…”
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