Search Results - "JAMA neurology"

Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders by Espay, Alberto J, Aybek, Selma, Carson, Alan, Edwards, Mark J, Goldstein, Laura H, Hallett, Mark, LaFaver, Kathrin, LaFrance, Jr, W Curt, Lang, Anthony E, Nicholson, Tim, Nielsen, Glenn, Reuber, Markus, Voon, Valerie, Stone, Jon, Morgante, Francesca

“…Functional neurological disorders (FND) are common sources of disability in medicine. Patients have often been misdiagnosed, correctly diagnosed after lengthy…”
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The Parkinson Pandemic-A Call to Action by Dorsey, E Ray, Bloem, Bastiaan R

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Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease by Mattsson, Niklas, Andreasson, Ulf, Zetterberg, Henrik, Blennow, Kaj

“…Existing cerebrospinal fluid (CSF) or imaging (tau positron emission tomography) biomarkers for Alzheimer disease (AD) are invasive or expensive. Biomarkers…”
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Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial by Mendell, Jerry R, Sahenk, Zarife, Lehman, Kelly, Nease, Carrie, Lowes, Linda P, Miller, Natalie F, Iammarino, Megan A, Alfano, Lindsay N, Nicholl, Amanda, Al-Zaidy, Samiah, Lewis, Sarah, Church, Kathleen, Shell, Richard, Cripe, Linda H, Potter, Rachael A, Griffin, Danielle A, Pozsgai, Eric, Dugar, Ashish, Hogan, Mark, Rodino-Klapac, Louise R

“…Micro-dystrophin gene transfer shows promise for treating patients with Duchenne muscular dystrophy (DMD) using recombinant adeno-associated virus serotype…”
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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis by Neu, Scott C, Pa, Judy, Kukull, Walter, Beekly, Duane, Kuzma, Amanda, Gangadharan, Prabhakaran, Wang, Li-San, Romero, Klaus, Arneric, Stephen P, Redolfi, Alberto, Orlandi, Daniele, Frisoni, Giovanni B, Au, Rhoda, Devine, Sherral, Auerbach, Sanford, Espinosa, Ana, Boada, Mercè, Ruiz, Agustín, Johnson, Sterling C, Koscik, Rebecca, Wang, Jiun-Jie, Hsu, Wen-Chuin, Chen, Yao-Liang, Toga, Arthur W

“…It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the…”
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Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial by Craft, Suzanne, Raman, Rema, Chow, Tiffany W, Rafii, Michael S, Sun, Chung-Kai, Rissman, Robert A, Donohue, Michael C, Brewer, James B, Jenkins, Cecily, Harless, Kelly, Gessert, Devon, Aisen, Paul S

“…Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain using intranasal devices. To date, the use of…”
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Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort by Gottesman, Rebecca F, Albert, Marilyn S, Alonso, Alvaro, Coker, Laura H, Coresh, Josef, Davis, Sonia M, Deal, Jennifer A, McKhann, Guy M, Mosley, Thomas H, Sharrett, A Richey, Schneider, Andrea L C, Windham, B Gwen, Wruck, Lisa M, Knopman, David S

“…Vascular risk factors have been associated with cognitive decline. Midlife exposure to these factors may be most important in conferring late-life risk of…”
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Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial by Schenkman, Margaret, Moore, Charity G, Kohrt, Wendy M, Hall, Deborah A, Delitto, Anthony, Comella, Cynthia L, Josbeno, Deborah A, Christiansen, Cory L, Berman, Brian D, Kluger, Benzi M, Melanson, Edward L, Jain, Samay, Robichaud, Julie A, Poon, Cynthia, Corcos, Daniel M

“…Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity…”
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Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex: A Placebo-Controlled Randomized Clinical Trial by Thiele, Elizabeth A, Bebin, E Martina, Bhathal, Hari, Jansen, Floor E, Kotulska, Katarzyna, Lawson, John A, O'Callaghan, Finbar J, Wong, Michael, Sahebkar, Farhad, Checketts, Daniel, Knappertz, Volker

“…Efficacy of cannabidiol has been demonstrated in seizures associated with Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in…”
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Effect of General Anesthesia and Conscious Sedation During Endovascular Therapy on Infarct Growth and Clinical Outcomes in Acute Ischemic Stroke: A Randomized Clinical Trial by Simonsen, Claus Z, Yoo, Albert J, Sørensen, Leif H, Juul, Niels, Johnsen, Søren P, Andersen, Grethe, Rasmussen, Mads

“…Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but…”
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Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis by Bloom, George S

“…The defining features of Alzheimer disease (AD) include conspicuous changes in both brain histology and behavior. The AD brain is characterized microscopically…”
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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Novel Meningoencephalomyelitis by Fang, Boyan, McKeon, Andrew, Hinson, Shannon R, Kryzer, Thomas J, Pittock, Sean J, Aksamit, Allen J, Lennon, Vanda A

“…A novel astrocytic autoantibody has been identified as a biomarker of a relapsing autoimmune meningoencephalomyelitis that is immunotherapy responsive…”
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Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains by Zeppenfeld, Douglas M, Simon, Matthew, Haswell, J Douglas, D'Abreo, Daryl, Murchison, Charles, Quinn, Joseph F, Grafe, Marjorie R, Woltjer, Randall L, Kaye, Jeffrey, Iliff, Jeffrey J

“…Cognitive impairment and dementia, including Alzheimer disease (AD), are common within the aging population, yet the factors that render the aging brain…”
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Clinical Presentation, Investigation Findings, and Treatment Outcomes of Spontaneous Intracranial Hypotension Syndrome: A Systematic Review and Meta-analysis by D'Antona, Linda, Jaime Merchan, Melida Andrea, Vassiliou, Anna, Watkins, Laurence Dale, Davagnanam, Indran, Toma, Ahmed Kassem, Matharu, Manjit Singh

“…Spontaneous intracranial hypotension (SIH) is a highly disabling but often misdiagnosed disorder. The best management options for patients with SIH are still…”
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Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing by Wilson, Michael R, O'Donovan, Brian D, Gelfand, Jeffrey M, Sample, Hannah A, Chow, Felicia C, Betjemann, John P, Shah, Maulik P, Richie, Megan B, Gorman, Mark P, Hajj-Ali, Rula A, Calabrese, Leonard H, Zorn, Kelsey C, Chow, Eric D, Greenlee, John E, Blum, Jonathan H, Green, Gary, Khan, Lillian M, Banerji, Debarko, Langelier, Charles, Bryson-Cahn, Chloe, Harrington, Whitney, Lingappa, Jairam R, Shanbhag, Niraj M, Green, Ari J, Brew, Bruce J, Soldatos, Ariane, Strnad, Luke, Doernberg, Sarah B, Jay, Cheryl A, Douglas, Vanja, Josephson, S Andrew, DeRisi, Joseph L

“…Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed. To present a case…”
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Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease by Musiek, Erik S, Bhimasani, Meghana, Zangrilli, Margaret A, Morris, John C, Holtzman, David M, Ju, Yo-El S

“…Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD) and have been hypothesized to contribute to disease pathogenesis. However, it is…”
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Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis by Leng, Yue, McEvoy, Claire T, Allen, Isabel E, Yaffe, Kristine

“…Growing evidence suggests an association between sleep-disordered breathing (SDB) and cognitive decline in elderly persons. However, results from…”
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Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis by Gomm, Willy, von Holt, Klaus, Thomé, Friederike, Broich, Karl, Maier, Wolfgang, Fink, Anne, Doblhammer, Gabriele, Haenisch, Britta

“…Medications that influence the risk of dementia in the elderly can be relevant for dementia prevention. Proton pump inhibitors (PPIs) are widely used for the…”
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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau by Hohman, Timothy J, Dumitrescu, Logan, Barnes, Lisa L, Thambisetty, Madhav, Beecham, Gary, Kunkle, Brian, Gifford, Katherine A, Bush, William S, Chibnik, Lori B, Mukherjee, Shubhabrata, De Jager, Philip L, Kukull, Walter, Crane, Paul K, Resnick, Susan M, Keene, C Dirk, Montine, Thomas J, Schellenberg, Gerard D, Haines, Jonathan L, Zetterberg, Henrik, Blennow, Kaj, Larson, Eric B, Johnson, Sterling C, Albert, Marilyn, Bennett, David A, Schneider, Julie A, Jefferson, Angela L

“…The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. Yet…”
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Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid by Shahnawaz, Mohammad, Tokuda, Takahiko, Waragai, Masaaki, Mendez, Nicolas, Ishii, Ryotaro, Trenkwalder, Claudia, Mollenhauer, Brit, Soto, Claudio

“…Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative disease associated with the accumulation of misfolded α-synuclein (αSyn)…”
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