Search Results - "JAKEMAN, David L"

5'-Chalcogen-Substituted Nucleoside Pyrophosphate and Phosphate Monoester Analogues: Preparation and Hydrolysis Studies by Mikkola, Satu, Eguaogie, Olga, Nieminen, Anu, Conlon, Patrick F, Jakeman, David L, Moore, Keith, Lane, Ian C, Vyle, Joseph S

“…Novel sulfur and selenium substituted 5',5'-linked dinucleoside pyrophate analogues were prepared in a vibration ball mill from the corresponding persilylated…”
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α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction by Jin, Yi, Bhattasali, Debabrata, Pellegrini, Erika, Forget, Stephanie M., Baxter, Nicola J., Cliff, Matthew J., Bowler, Matthew W., Jakeman, David L., Blackburn, G. Michael, Waltho, Jonathan P.

“…β-Phosphoglucomutase (βPGM) catalyzes isomerization of β- d -glucose 1-phosphate (βG1P) into d -glucose 6-phosphate (G6P) via sequential phosphoryl transfer…”
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Eight-Membered Ring-Containing Jadomycins: Implications for Non-enzymatic Natural Products Biosynthesis by Robertson, Andrew W, Martinez-Farina, Camilo F, Smithen, Deborah A, Yin, Huimin, Monro, Susan, Thompson, Alison, McFarland, Sherri A, Syvitski, Raymond T, Jakeman, David L

“…Jadomycin Oct (1) was isolated from Streptomyces venezuelae ISP5230 and characterized as a structurally unique eight-membered l-ornithine ring-containing…”
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Characterization of l‑Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230 by Robertson, Andrew W, Martinez-Farina, Camilo F, Syvitski, Raymond T, Jakeman, David L

“…The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient…”
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Isolation and Synthetic Diversification of Jadomycin 4‑Amino‑l‑phenylalanine by Martinez-Farina, Camilo F, Robertson, Andrew W, Yin, Huimin, Monro, Susan, McFarland, Sherri A, Syvitski, Raymond T, Jakeman, David L

“…Streptomyces venezuelae ISP5230 was grown in the presence of phenylalanine analogues to observe whether they could be incorporated into novel jadomycin…”
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Synthesis and antimalarial activity of prodigiosenes by Marchal, Estelle, Smithen, Deborah A, Uddin, Md Imam, Robertson, Andrew W, Jakeman, David L, Mollard, Vanessa, Goodman, Christopher D, MacDougall, Kristopher S, McFarland, Sherri A, McFadden, Geoffrey I, Thompson, Alison

“…Several analogues of the natural compound prodigiosin with modified A- and C-rings were synthesised as were some of their tin, cobalt, boron and zinc…”
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Synthesis and Evaluation of l‑Rhamnose 1C-Phosphonates as Nucleotidylyltransferase Inhibitors by Loranger, Matthew W, Forget, Stephanie M, McCormick, Nicole E, Syvitski, Raymond T, Jakeman, David L

“…We report the synthesis of a series of phosphonates and ketosephosphonates possessing an l-rhamnose scaffold with varying degrees of fluorination. These…”
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Introductory Medicinal Chemistry for Pharmacy Students: An Assignment-Based Online Assessment Strategy by Jakeman, David L.

“…New assessment approaches for medicinal chemistry in an introductory course within the pharmacy curriculum are presented. A required introductory…”
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Antimicrobial Activities of Jadomycin B and Structurally Related Analogues by JAKEMAN, David L, BANDI, Srinivasulu, GRAHAM, Cathy L, REID, Taryn R, WENTZELL, Jason R, DOUGLAS, Susan E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Isolation of a jadomycin incorporating l-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells by Forget, Stephanie M., Robertson, Andrew W., Hall, Steven R., MacLeod, Jeanna M., Overy, David P., Kerr, Russell G., Goralski, Kerry B., Jakeman, David L.

“…Herein, we report the characterization and antimicrobial activity of a previously unreported jadomycin ( 1 ) obtained from a culture of S. venezuelae ISP5230…”
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Stereoselective Chemical Synthesis of Sugar Nucleotides via Direct Displacement of Acylated Glycosyl Bromides by Timmons, Shannon C, Jakeman, David L

“…The use of Leloir glycosyltransferases to prepare biologically relevant oligosaccharides and glycoconjugates requires access to sugar nucleoside diphosphates,…”
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Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase by Carroll-Poehls, Madison, Jakeman, David L.

“…β-phosphoglucomutase (βPGM) catalyzes the conversion of β-glucose 1-phosphate (βG1P) to glucose-6-phosphate (G6P), a universal source of cellular energy, in a…”
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Diverse DNA-Cleaving Capacities of the Jadomycins through Precursor-Directed Biosynthesis by Cottreau, Krista M, Spencer, Colin, Wentzell, Jason R, Graham, Cathy L, Borissow, Charles N, Jakeman, David L, McFarland, Sherri A

“…Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found…”
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Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono‑, Di‑, and Trifluorinated d‑Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition by Zhu, Jian-She, Stiers, Kyle M, Winter, Sherany M, Garcia, Anthony D, Versini, Antoine F, Beamer, Lesa J, Jakeman, David L

“…Glucokinase phosphorylated a series of C-1 fluorinated α-d-gluco-heptuloses. These phosphorylated products were discovered to be inhibitors of…”
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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase by Stiers, Kyle M., Graham, Abigail C., Zhu, Jian-She, Jakeman, David L., Nix, Jay C., Beamer, Lesa J.

“…Enzymes are known to adopt various conformations at different points along their catalytic cycles. Here, we present a comprehensive analysis of 15 isomorphous,…”
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Jadomycins Derived from the Assimilation and Incorporation of Norvaline and Norleucine by Dupuis, Stephanie N, Veinot, Thomas, Monro, Susan M. A, Douglas, Susan E, Syvitski, Raymond T, Goralski, Kerry B, McFarland, Sherri A, Jakeman, David L

“…Streptomyces venezuelae ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are…”
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Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Streptococcus mutans by SYVITSKI, Raymond T, TIAN, Xiao-Lin, SAMPARA, Kamal, SALMAN, Alan, LEE, Song F, JAKEMAN, David L, LI, Yung-Hua

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Stereochemical Integrity of Oxazolone Ring-Containing Jadomycins by Borissow, Charles N., Graham, Cathy L., Syvitski, Ray T., Reid, Taryn R., Blay, Jonathan, Jakeman, David L.

“…The jadomycins are a series of natural products produced by Streptomyces venzuelae ISP5230 in response to ethanol shock. A unique structural feature of these…”
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Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues by Martinez-Farina, Camilo F, Jakeman, David L

“…We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product…”
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Synthesis of 5′-Thymidine-Conjugated Formylphenylboronic Acids as Potential Lysine Targeting Iminoboronate Reversible Covalent Enzyme Probes by Rangaswamy, Alana M. M., Beh, Michael H. R., Soleimani, Ebrahim, Sequeira, Steve, Cormier, Julie, Robertson, Katherine N., Jakeman, David L.

“…The design of reversible-covalent molecules to selectively target the ε-amino functionality of lysine residues in enzymes or proteins is a highly desirable…”
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