Search Results - "JAILLON, P"

Environmental and genetic factors associated with morphine response in the postoperative period by Coulbault, Laurent, Beaussier, Marc, Verstuyft, Céline, Weickmans, Henri, Dubert, Liliane, Trégouet, David, Descot, Christelle, Parc, Yann, Lienhart, André, Jaillon, Patrice, Becquemont, Laurent

“…Objective The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects…”
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Bisoprolol dose–response relationship in patients with congestive heart failure: a subgroup analysis in the cardiac insufficiency bisoprolol study (CIBIS II) by Simon, T., Mary-Krause, M., Funck-Brentano, C., Lechat, Ph, Jaillon, P.

“…Aims Whether all patients with congestive heart failure (CHF) need to reach the target dose of beta-blocker to obtain a benefit in terms of survival remains…”
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Amiodarone Interacts with Simvastatin but not with Pravastatin Disposition Kinetics by Becquemont, L, Neuvonen, M, Verstuyft, C, Jaillon, P, Letierce, A, Neuvonen, P J, Funck‐Brentano, C

“…The aim of this study was to determine the influence of amiodarone on the pharmacokinetics of simvastatin and pravastatin in humans. This was a prospective,…”
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Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the cardiac insufficiency BIsoprolol study (CIBIS) by LECHAT, P, ESCOLANO, S, MALLET, A, GOLMARD, J. L, LARDOUX, H, WITCHITZ, S, HENNEMAN, J. A, MAISCH, B, HETZEL, M, JAILLON, P, BOISSEL, J.-P

“…To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and…”
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The control of prescription drug advertising: A controversial issue by Jaillon, P.

“…Clinical Pharmacology & Therapeutics (2000) 68, 583–585; doi: 10.1067/mcp.2000.111947…”
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Rate-corrected QT interval: Techniques and limitations by Funck-Brentano, Christian, Jaillon, Patrice

“…The duration of the QT interval on the surface electrocardiogram represents the time required for all ventricular depolarization and repolarization processes…”
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Overview of electrocardiographic and cardiovascular safety data for sparfloxacin by Jaillon, P., Morganroth, J., Brumpt, I., Talbot, G.

“…During the preclinical development of sparfloxacin, prolongation of the electrocardiographic QT interval was observed in dogs. Subsequently, the effect of…”
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Influence of tamoxifen on carotid intima-media thickness in postmenopausal women by SIMON, T, BOUTOUYRIE, P, SIMON, J. M, LALOUX, B, TOURNIGAND, C, TROPEANO, A. I, LAURENT, S, JAILLON, P

“…Intima-media thickness of the common carotid artery (IMT-CCA) is an early marker of atherosclerosis. Tamoxifen is a selective estrogen-receptor modulator with…”
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Genetic and environmental risk factors for oral anticoagulant overdose by VERSTUYFT, C, ROBERT, A, MORIN, S, LORIOT, M. A, FLAHAULT, A, BEAUNE, P, FUNCK-BRENTANO, C, JAILLON, P, BECQUEMONT, L

“…Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin…”
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Electrophysiological effects of cetirizine, astemizole and d-sotalol in a canine model of long QT syndrome by Weissenburger, J., Noyer, M., Cheymol, G., Jaillon, P.

“…Observations of torsades de pointes during therapy with terfenadine and astemizole has raised concern about the cardiac safety of non‐sedating H1‐antagonist…”
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Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers by Simon, T., Becquemont, L., Hamon, B., Nouyrigat, E., Chodjania, Y., Poirier, J. M., Funck‐Brentano, C., Jaillon, P.

“…Aims  To assess the age‐associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. Methods …”
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Is diclofenac a valuable CYP2C9 probe in humans? by MORIN, S, LORIOT, M. A, POIRIER, J. M, TENNEZE, L, BEAUNE, P. H, FUNCK-BRENTANO, C, JAILLON, P, BECQUEMONT, L

“…Besides the low therapeutic index drug tolbutamide, there is no validated in vivo probe to assess the genetically determined CYP2C9 activity in humans. The in…”
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Management of atrial fibrillation in France: the observational FACTUEL study by Mabo, P, Leenhardt, A, Jaillon, P, Kacet, S, Aubin, F, Denjoy, I, Le Heuzey, J-Y

“…To describe the management of patients with atrial fibrillation (AF) and to study consistency with guidelines on management of AF. Observational study on a…”
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Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers by DEMOLIS, J.‐L., CHARRANSOL, A., FUNCK‐BRENTANO, C., JAILLON, P.

“…1Sparfloxacin, a new fluoroquinolone, slightly increases the duration of the QT interval. Reverse rate‐dependence of QT interval prolongation has been shown…”
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Assessment of the sustained release properties of a new oral formulation of trimetazidine in pigs and dogs and confirmation in healthy human volunteers by GENISSEL, P, CHODJANIA, Y, DEMOLIS, J. L, RAGUENEAU, I, JAILLON, P

“…The pharmacokinetics of immediate (IR) and modified release (MR) trimetazidine (TMZ) in dogs and pigs, have been compared under single dose conditions, then…”
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Antianginal and Antiischemic Effects of Ivabradine, an I f Inhibitor, in Stable Angina: A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial by Borer, Jeffrey S., Fox, Kim, Jaillon, Patrice, Lerebours, Guy

“…Background— Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand…”
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Hormone replacement therapy in postmenopausal women at cardiovascular risk: epidemiology and clinical trials by SIMON, T, JAILLON, P

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The respective roles of controlled clinical trials and cohort monitoring studies in the pre- and postmarketing assessment of drugs by Vray, Muriel, Hamelin, Bernard, Jaillon, Patrice

“…The respective roles of controlled clinical trials and observational studies (cohort or case-control studies) in evaluating the efficacy, safety and usefulness…”
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Les essais cliniques de phase 1 by JAILLON, P

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Hormone replacement therapy: where we stand in Europe by Rosano, G.M.C., Simon, T., Mercuro, G., Sans, S., Schenck-Gustaffson, K., Stevenson, J.C., Swahn, E., Jaillon, P.

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