Search Results - "JAHRSDORFER, Bernd"

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors by Jahrsdörfer, Bernd, Groß, Rüdiger, Seidel, Alina, Wettstein, Lukas, Ludwig, Carolin, Schwarz, Tatjana, Körper, Sixten, Rojewski, Markus, Lotfi, Ramin, Weinstock, Christoph, Seifried, Erhard, Corman, Victor Max, Drosten, Christian, Münch, Jan, Schrezenmeier, Hubert

“…The current SARS-CoV-2 pandemic has triggered the development of various SARS-CoV-2 neutralization tests. A wild-type virus (using African green monkey VeroE6…”
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B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation by Jahrsdörfer, Bernd, Blackwell, Sue E., Wooldridge, James E., Huang, Jian, Andreski, Melinda W., Jacobus, Laura S., Taylor, Christiana M., Weiner, George J.

“…B cells currently are not viewed as being capable of producing granzyme B or being cytotoxic. We found that B-chronic lymphocytic leukemia (B-CLL) cells…”
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ATP promotes immunosuppressive capacities of mesenchymal stromal cells by enhancing the expression of indoleamine dioxygenase by Lotfi, Ramin, Steppe, Lena, Hang, Regina, Rojewski, Markus, Massold, Marina, Jahrsdörfer, Bernd, Schrezenmeier, Hubert

“…Introduction MSCs are often found within tumors, promote cancer progression and enhance metastasis. MSCs can act as immuosuppressive cells, partially due to…”
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S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes by Eisenbacher, Judith Luiza, Schrezenmeier, Hubert, Jahrsdörfer, Bernd, Kaltenmeier, Christof, Rojewski, Markus Thomas, Yildiz, Tatjana, Beyer, Thamara, Erle, Alexander, Wiegmann, Denis Sebastian, Grassl, Stefan, Hang, Regina, Körper, Sixten, Wiesneth, Markus, Lotze, Michael T, Lotfi, Ramin

“…Simple stress or necrotic cell death with subsequent release of damage-associated molecular patterns (DAMPs) is a characteristic feature of most advanced…”
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Peritumoral CpG DNA Elicits a Coordinated Response of CD8 T Cells and Innate Effectors to Cure Established Tumors in a Murine Colon Carcinoma Model by Heckelsmiller, Klaus, Rall, Katharina, Beck, Sebastian, Schlamp, Angelika, Seiderer, Julia, Jahrsdorfer, Bernd, Krug, Anne, Rothenfusser, Simon, Endres, Stefan, Hartmann, Gunther

“…The immune system of vertebrates is able to detect bacterial DNA based on the presence of unmethylated CpG motifs. We examined the therapeutic potential of…”
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CD5⁺ B cells from individuals with systemic lupus erythematosus express granzyme B by Hagn, Magdalena, Ebel, Verena, Sontheimer, Kai, Schwesinger, Elisabeth, Lunov, Oleg, Beyer, Thamara, Fabricius, Dorit, Barth, Thomas F.E, Viardot, Andreas, Stilgenbauer, Stephan, Hepp, Julia, Scharffetter-Kochanek, Karin, Simmet, Thomas, Jahrsdörfer, Bernd

“…Recently, we reported that IL-21 induces granzyme B (GzmB) and GzmB-dependent apoptosis in malignant CD5⁺ B cells from patients with chronic lymphocytic…”
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SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies by Hoffmann, Markus, Arora, Prerna, Groß, Rüdiger, Seidel, Alina, Hörnich, Bojan F., Hahn, Alexander S., Krüger, Nadine, Graichen, Luise, Hofmann-Winkler, Heike, Kempf, Amy, Winkler, Martin S., Schulz, Sebastian, Jäck, Hans-Martin, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Müller, Martin, Kleger, Alexander, Münch, Jan, Pöhlmann, Stefan

“…The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used…”
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Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells by Fabricius, Dorit, Nußbaum, Benedikt, Busch, Daniel, Panitz, Verena, Mandel, Birgit, Vollmer, Angelika, Westhoff, Mike-Andrew, Kaltenmeier, Christof, Lunov, Oleg, Tron, Kyrylo, Nienhaus, G Ulrich, Jahrsdörfer, Bernd, Debatin, Klaus-Michael

“…Human plasmacytoid dendritic cells (pDC) are important modulators of adaptive T cell responses during viral infections. Recently, we found that human pDC…”
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Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients by Sattler, Arne, Schrezenmeier, Eva, Weber, Ulrike A, Potekhin, Alexander, Bachmann, Friederike, Straub-Hohenbleicher, Henriette, Budde, Klemens, Storz, Elena, Pross, Vanessa, Bergmann, Yasmin, Thole, Linda M.L, Tizian, Caroline, Holsken, Oliver, Diefenbach, Andreas, Schrezenmeier, Hubert, Jahrsdorfer, Bernd, Zemojtel, Tomasz, Jechow, Katharina, Conrad, Christian, Lukassen, Soren, Stauch, Diana, Lachmann, Nils, Choi, Mira, Halleck, Fabian, Kotsch, Katja

“…Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty)…”
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B-Cell Lymphomas Differ in their Responsiveness to CpG Oligodeoxynucleotides by JAHRSDORFER, Bernd, MÜHLENHOFF, Lars, WEINER, George J, HARTMANN, Gunther, BLACKWELL, Sue E, WAGNER, Moritz, POECK, Hendrik, HARTMANN, Evelyn, JOX, Ralf, GIESE, Thomas, EMMERICH, Bertold, ENDRES, Stefan

“…Human B cells detect CpG motifs within microbial DNA via TLR9. Synthetic CpG oligodeoxynucleotides are currently being tested in clinical trials for the…”
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B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients by Schrezenmeier, Eva, Rincon-Arevalo, Hector, Stefanski, Ana-Luisa, Potekhin, Alexander, Staub-Hohenbleicher, Henriette, Choi, Mira, Bachmann, Friederike, Proβ, Vanessa, Hammett, Charlotte, Schrezenmeier, Hubert, Ludwig, Carolin, Jahrsdörfer, Bernd, Lino, Andreia C, Eckardt, Kai-Uwe, Kotsch, Katja, Dörner, Thomas, Budde, Klemens, Sattler, Arne, Halleck, Fabian

“…Accumulating evidence sugges ts solid organ transplant recipients, as opposed to the general population, show strongly impaired responsiveness toward standard…”
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Quantitative Expression of Toll-Like Receptor 1-10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides by Hornung, Veit, Rothenfusser, Simon, Britsch, Stefanie, Krug, Anne, Jahrsdorfer, Bernd, Giese, Thomas, Endres, Stefan, Hartmann, Gunther

“…The Toll-like receptor (TLR)9 is critical for the recognition of immunostimulatory CpG motifs but may cooperate with other TLRs. We analyzed TLR1-10 mRNA…”
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Interleukin 21―Induced Granzyme B―Expressing B Cells Infiltrate Tumors and Regulate T Cells by LINDNER, Stefanie, DAHLKE, Karen, LUNOV, Oleg, NIENHAUS, G. Ulrich, SIMMET, Thomas, KREIENBERG, Rolf, MÖLLER, Peter, SCHREZENMEIER, Hubert, JAHRSDÖRFER, Bernd, SONTHEIMER, Kai, HAGN, Magdalena, KALTENMEIER, Christof, BARTH, Thomas F. E, BEYER, Thamara, REISTER, Frank, FABRICIUS, Dorit, LOTFI, Ramin

“…The pathogenic impact of tumor-infiltrating B cells is unresolved at present, however, some studies suggest that they may have immune regulatory potential…”
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Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21 by Hagn, Magdalena, Schwesinger, Elisabeth, Ebel, Verena, Sontheimer, Kai, Maier, Julia, Beyer, Thamara, Syrovets, Tatiana, Laumonnier, Yves, Fabricius, Dorit, Simmet, Thomas, Jahrsdorfer, Bernd

“…Human B cells are currently not known to produce the proapoptotic protease granzyme B (GrB) in physiological settings. We have discovered that BCR stimulation…”
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Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants by Groß, Rüdiger, Zanoni, Michelle, Seidel, Alina, Conzelmann, Carina, Gilg, Andrea, Krnavek, Daniela, Erdemci-Evin, Sümeyye, Mayer, Benjamin, Hoffmann, Markus, Pöhlmann, Stefan, Liu, Weimin, Hahn, Beatrice H., Beil, Alexandra, Kroschel, Joris, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kirchhoff, Frank, Münch, Jan, Müller, Janis A.

“…Heterologous COVID-19 vaccination regimens combining vector- and mRNA-based vaccines are already administered, but data on solicited adverse reactions,…”
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Regulatory B Cells-Immunopathological and Prognostic Potential in Humans by Veh, Johanna, Ludwig, Carolin, Schrezenmeier, Hubert, Jahrsdörfer, Bernd

“…The aim of the following review is to shed light on the putative role of regulatory B cells (Bregs) in various diseases and highlight their potential…”
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Treosulfan is an effective inducer of cell death in myeloma cell lines and primary myeloma cells from patients by Meinhardt, Gerold, Dayyani, Farshid, Jahrsdörfer, Bernd, Baumgart, Joachim, Emmerich, Bertold, Schmidmaier, Ralf

“…Multiple myeloma is a non‐curable haematological disease involving transformed plasma cells. High rates of complete remission can be achieved with autologous…”
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CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients by Kaltenmeier, Christof, Gawanbacht, Ali, Beyer, Thamara, Lindner, Stefanie, Trzaska, Timo, van der Merwe, Johannes Andreas, Härter, Georg, Grüner, Beate, Fabricius, Dorit, Lotfi, Ramin, Schwarz, Klaus, Schütz, Catharina, Hönig, Manfred, Schulz, Ansgar, Kern, Peter, Bommer, Martin, Schrezenmeier, Hubert, Kirchhoff, Frank, Jahrsdörfer, Bernd

“…IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced…”
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High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection by Jacobsen, Eva-Maria, Fabricius, Dorit, Class, Magdalena, Topfstedt, Fernando, Lorenzetti, Raquel, Janowska, Iga, Schmidt, Franziska, Staniek, Julian, Zernickel, Maria, Stamminger, Thomas, Dietz, Andrea N., Zellmer, Angela, Hecht, Manuel, Rauch, Peter, Blum, Carmen, Ludwig, Carolin, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Heeg, Maximilian, Mayer, Benjamin, Seidel, Alina, Groß, Rüdiger, Münch, Jan, Kirchhoff, Frank, Bode, Sebastian F. N., Strauss, Gudrun, Renk, Hanna, Elling, Roland, Stich, Maximillian, Voll, Reinhard E., Tönshof, Burkhard, Franz, Axel R., Henneke, Philipp, Debatin, Klaus-Michael, Rizzi, Marta, Janda, Ales

“…The COVID-19 course and immunity differ in children and adults. We analyzed immune response dynamics in 28 families up to 12 months after mild or asymptomatic…”
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Phorbol-12-myristate-13-acetate is a potent enhancer of B cells with a granzyme B+ regulatory phenotype by Veh, Johanna, Mangold, Charlotte, Felsen, Anja, Ludwig, Carolin, Gerstner, Lisa, Reinhardt, Peter, Schrezenmeier, Hubert, Fabricius, Dorit, Jahrsdörfer, Bernd

“…Introduction The infusion of ex-vivo -generated regulatory B cells may represent a promising novel therapeutic approach for a variety of autoimmune and…”
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