Search Results - "JAHARUL HAQUE, S"
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Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology
Published in Cancers (12-02-2021)“…One of the main reasons for the aggressive behavior of glioblastoma (GBM) is its intrinsic intra-tumor heterogeneity, characterized by the presence of clonal…”
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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
Published in Oncogene (05-12-2002)“…Glioblastoma multiforme (GBM), the most common and malignant central nervous system tumor in humans, is highly proliferative and resistant to apoptosis. Stat3,…”
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TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways
Published in Scientific reports (01-08-2023)“…GBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to…”
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4
STAT3-mediated Coincidence Detection Regulates Noncanonical Immediate Early Gene Induction
Published in The Journal of biological chemistry (26-04-2013)“…Signaling pathways interact with one another to form dynamic networks in which the cellular response to one stimulus may depend on the presence, intensity,…”
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5
Pediatric hypereosinophilic syndrome (HES) differs from adult HES
Published in The Journal of pediatrics (2005)“…The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who presented with colitis, cough, rash, and hepatitis. Molecular analysis…”
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PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells
Published in Oncogene (10-11-2005)“…Glioblastoma multiforme (GBM) cells frequently harbor amplification and/or gain-of-function mutation of the EGFR gene leading to the activation of multiple…”
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The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas
Published in Cancers (10-07-2017)“…MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The…”
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miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma
Published in Oncogene (01-04-2019)“…Glioblastomas (GBMs) are the most aggressive primary brain tumors, with an average survival of less than 15 months. Therefore, there is a critical need to…”
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MicroRNA-575 acts as a novel oncogene via targeting multiple signaling pathways in glioblastoma
Published in Experimental and molecular pathology (01-10-2022)“…Glioblastoma (GBM) patients currently face poor survival outcomes with an average survival period of <15 months, while only 3–5% of patients survive longer…”
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10
Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1
Published in Journal of leukocyte biology (01-10-2005)“…Mutations in the granulocyte‐colony stimulating factor receptor (G‐CSF‐R) gene resulting in carboxy terminal truncation have been associated with acute myeloid…”
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MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways
Published in Cell cycle (Georgetown, Tex.) (01-01-2015)“…Over 90% of pancreatic adenocarcinoma PC express oncogenic mutant KRAS that constitutively activates the Raf-MEK-MAPK pathway conferring resistance to both…”
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A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Published in Molecular cancer research (01-01-2021)“…Rapid tumor growth, widespread brain-invasion, and therapeutic resistance critically contribute to glioblastoma (GBM) recurrence and dismal patient outcomes…”
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13
STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation
Published in American journal of physiology. Lung cellular and molecular physiology (01-07-2003)“…Interferon-gamma (IFN-gamma) is required for induction of the human nitric oxide synthase-2 (NOS2) gene in lung epithelium. Although the human NOS2 promoter…”
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Redox Regulation of Interleukin-4 Signaling
Published in Immunity (Cambridge, Mass.) (17-10-2008)“…The physiologic control of cytokine receptor activation is primarily mediated by reciprocal activation of receptor-associated protein tyrosine kinases and…”
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MicroRNA Biomarkers for Patients With Muscle-Invasive Bladder Cancer Undergoing Selective Bladder-Sparing Trimodality Treatment
Published in International journal of radiation oncology, biology, physics (01-05-2019)“…Trimodality therapy with maximal transurethral resection of bladder tumor and definitive chemoradiation reserving cystectomy for salvage of local recurrence is…”
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Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
Published in Cell reports. Medicine (20-06-2023)“…Genetic alterations help predict the clinical behavior of diffuse gliomas, but some variability remains uncorrelated. Here, we demonstrate that…”
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Receptor-Associated Constitutive Protein Tyrosine Phosphatase Activity Controls the Kinase Function of JAK1
Published in Proceedings of the National Academy of Sciences - PNAS (05-08-1997)“…Exposure of cells to protein tyrosine phosphatase (PTP) inhibitors causes an increase in the phosphotyrosine content of many cellular proteins. However, the…”
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p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation
Published in Oncotarget (01-08-2010)“…Tumorigenic potential of glioblastoma multiforme (GBM) cells is, in part, attributable to their undifferentiated (neural stem cell-like) phenotype. Astrocytic…”
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Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis
Published in Immunity (Cambridge, Mass.) (01-05-2003)“…Viral infection is the primary cause of respiratory morbidity in cystic fibrosis (CF) infants. Here, we identify that host factors allow increased virus…”
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The possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro
Published in The Journal of immunology (1950) (01-04-2003)“…Osteoclast formation is dependent on the ability of TGF-beta to enable receptor activator of NF-kappaB ligand (RANKL)-induced commitment of hemopoietic…”
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