Search Results - "JAGAVELU, Kumaravelu"

Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin by Aggarwal, Hobby, Pathak, Priya, Kumar, Yashwant, Jagavelu, Kumaravelu, Dikshit, Madhu

“…Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS mice have demonstrated…”
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Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice by Zhu, Qiang, Zou, Li, Jagavelu, Kumaravelu, Simonetto, Douglas A, Huebert, Robert C, Jiang, Zhi-Dong, DuPont, Herbert L, Shah, Vijay H

“…Background & Aims Liver fibrosis is associated with angiogenesis and leads to portal hypertension. Certain antibiotics reduce complications of liver failure in…”
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Ameliorating impaired cardiac function in myocardial infarction using exosome-loaded gallic-acid-containing polyurethane scaffolds by Das, Ankita, Nikhil, Aman, Shiekh, Parvaiz Ahmad, Yadav, Babita, Jagavelu, Kumaravelu, Kumar, Ashok

“…Myocardial infarction (MI) can be tackled by implanting cardiac patches which provide mechanical support to the heart. However, most tissue-engineered…”
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Neuropilin-1 Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment by YAQOOB, Usman, SHENG CAO, SCHWARTZ, Martin, JU DONG YANG, EHMAN, Richard, ROBERTS, Lewis, MUKHOPADHYAY, Debabrata, SHAH, Vijay H, SHERGILL, Uday, JAGAVELU, Kumaravelu, ZHIMIN GENG, MENG YIN, ASSUNCAO, Thiago M. De, YING CAO, SZABOLCS, Anna, THORGEIRSSON, Snorri

“…The tumor microenvironment, including stromal myofibroblasts and associated matrix proteins, regulates cancer cell invasion and proliferation. Here, we report…”
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Standardized Xylocarpus moluccensis fruit fraction mitigates collagen‐induced arthritis in mice by regulating immune response by Gupta, Priya, Kumar, Amit, Pal, Subhashis, Kumar, Sachin, Lahiri, Amit, Kumaravelu, Jagavelu, Chattopadhyay, Naibedya, Dikshit, Madhu, Barthwal, Manoj Kumar

“…Objective This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen‐induced arthritis in…”
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Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance by Kanuri, Babu Nageswararao, Kanshana, Jitendra S., Rebello, Sanjay C., Pathak, Priya, Gupta, Anand P., Gayen, Jiaur R., Jagavelu, Kumaravelu, Dikshit, Madhu

“…On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin…”
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Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice by Aggarwal, Hobby, Pathak, Priya, Singh, Vishal, Kumar, Yashwant, Shankar, Manoharan, Das, Bhabatosh, Jagavelu, Kumaravelu, Dikshit, Madhu

“…The role of oxidative and nitrosative stress has been implied in both physiology and pathophysiology of metabolic disorders. Inducible nitric oxide synthase…”
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Endothelial cell toll‐like receptor 4 regulates fibrosis‐associated angiogenesis in the liver by Jagavelu, Kumaravelu, Routray, Chittaranjan, Shergill, Uday, O'Hara, Steven P., Faubion, William, Shah, Vijay H.

“…Angiogenesis defines the growth of new blood vessels from preexisting vascular endothelial networks and corresponds to the wound healing process that is…”
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FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway by Yaqoob, Usman, Jagavelu, Kumaravelu, Shergill, Uday, de Assuncao, Thiago, Cao, Sheng, Shah, Vijay H

“…Binding of angiogenic molecules with cognate receptor tyrosine kinases (RTK) is required for angiogenesis however the precise link between RTK binding,…”
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Aquaporin-1 Promotes Angiogenesis, Fibrosis, and Portal Hypertension Through Mechanisms Dependent on Osmotically Sensitive MicroRNAs by Huebert, Robert C, Jagavelu, Kumaravelu, Hendrickson, Helen I, Vasdev, Meher M, Arab, Juan P, Splinter, Patrick L, Trussoni, Christy E, LaRusso, Nicholas F, Shah, Vijay H

“…Changes in hepatic vasculature accompany fibrogenesis, and targeting angiogenic molecules often attenuates fibrosis in animals. Aquaporin-1 (AQP1) is a water…”
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Systemic Insulin Resistance and Metabolic Perturbations in Chow Fed Inducible Nitric Oxide Synthase Knockout Male Mice: Partial Reversal by Nitrite Supplementation by Aggarwal, Hobby, Pathak, Priya, Singh, Pragati, Gayen, Jiaur R., Jagavelu, Kumaravelu, Dikshit, Madhu

“…iNOS, an important mediator of inflammation, has emerged as an important metabolic regulator. There are conflicting observations on the incidence of insulin…”
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MAP-Kinase Activated Protein Kinase 2 Links Endothelial Activation and Monocyte/macrophage Recruitment in Arteriogenesis by Limbourg, Anne, von Felden, Johann, Jagavelu, Kumaravelu, Krishnasamy, Kashyap, Napp, L Christian, Kapopara, Piyushkumar R, Gaestel, Matthias, Schieffer, Bernhard, Bauersachs, Johann, Limbourg, Florian P, Bavendiek, Udo

“…Arteriogenesis, the growth of natural bypass arteries, is triggered by hemodynamic forces within vessels and requires a balanced inflammatory response,…”
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Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein–Coupled Receptors by Singh, Nidhi, Yadav, Manisha, Singh, Abhishek Kumar, Kumar, Harish, Dwivedi, Shailendra Kumar Dhar, Mishra, Jay Sharan, Gurjar, Anagha, Manhas, Amit, Chandra, Sharat, Yadav, Prem Narayan, Jagavelu, Kumaravelu, Siddiqi, Mohammad Imran, Trivedi, Arun Kumar, Chattopadhyay, Naibedya, Sanyal, Sabyasachi

“…The synthetic nuclear bile acid receptor (farnesoid X receptor [FXR]) agonist GW4064 is extensively used as a specific pharmacological tool to illustrate FXR…”
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Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis by Huebert, Robert C, Jagavelu, Kumaravelu, Liebl, Ann F, Huang, Bing Q, Splinter, Patrick L, LaRusso, Nicholas F, Urrutia, Raul A, Shah, Vijay H

“…Hepatic sinusoidal endothelial cells (HSECs) are a unique subpopulation of fenestrated endothelial cells lining the hepatic sinusoids and comprising the…”
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Systemic Deficiency of the MAP Kinase-Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice by Jagavelu, Kumaravelu, Tietge, Uwe J.F, Gaestel, Matthias, Drexler, Helmut, Schieffer, Bernhard, Bavendiek, Udo

“…Atherosclerosis is a chronic inflammatory disease and represents the major cause of cardiovascular morbidity and mortality. A critical regulator of…”
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Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man by Luchtefeld, Maren, Schunkert, Heribert, Stoll, Monika, Selle, Tina, Lorier, Rachel, Grote, Karsten, Sagebiel, Christian, Jagavelu, Kumaravelu, Tietge, Uwe J F, Assmus, Ulrike, Streetz, Konrad, Hengstenberg, Christian, Fischer, Marcus, Mayer, Björn, Maresso, Karen, El Mokhtari, Nour Eddine, Schreiber, Stefan, Müller, Werner, Bavendiek, Udo, Grothusen, Christina, Drexler, Helmut, Trautwein, Christian, Broeckel, Ulrich, Schieffer, Bernhard

“…Liver-derived acute phase proteins (APPs) emerged as powerful predictors of cardiovascular disease and cardiovascular events, but their functional role in…”
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Involvement of HIF1α/Reg protein in the regulation of HMGB3 in myocardial infarction by Manhas, Amit, Tripathi, Dipti, Jagavelu, Kumaravelu

“…Myocardial ischemia and infarction are the number one cause of cardiovascular disease associated mortality. Cardiomyocyte death during ischemia leads to the…”
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Inhibition of fatty acid synthase is protective in pulmonary hypertension by Singh, Neetu, Manhas, Amit, Kaur, Gurpreet, Jagavelu, Kumaravelu, Hanif, Kashif

“…Background and Purpose In pulmonary hypertension (PH), similar to cancer, there is altered energy metabolism, apoptosis resistance and cellular proliferation…”
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Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension by Singh, Neetu, Shafiq, Mohammad, Jagavelu, Kumaravelu, Hanif, Kashif

“…Apart from pulmonary vascular resistance and right ventricle (RV) hypertrophy, metabolic dysfunction also plays a major role in pathophysiology of pulmonary…”
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Inhibition of NADPH Oxidase-4 Potentiates 2-Deoxy-D-Glucose-Induced Suppression of Glycolysis, Migration, and Invasion in Glioblastoma Cells: Role of the Akt/HIF1α/HK-2 Signaling Axis by Gupta, Priyanka, Jagavelu, Kumaravelu, Mishra, Durga Prasad

“…2-Deoxy-d-glucose (2-DG), a synthetic glycolytic inhibitor, is currently under clinical evaluation as a promising anticancer agent. However, 2-DG treatment in…”
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